ZNF134 Activators
ZNF134 Activators are a collection of chemical compounds that indirectly augment the functional activity of ZNF134, primarily through modulation of various cellular signaling pathways that influence gene transcription, which is central to ZNF134's role. Forskolin, by increasing intracellular cAMP levels, activates PKA, which in turn may phosphorylate transcription factors leading to enhanced ZNF134 expression. Similarly, PMA, through activation of PKC, and Epigallocatechin gallate, as a kinase inhibitor, contribute to the modification of signaling pathways that may lead to upregulated ZNF134 expression. LY294002 and Wortmannin, both PI3K inhibitors, and U0126, a MEK inhibitor, can shift cellular signaling dynamics, potentially enhancing transcriptional pathways that upregulate ZNF134. Additionally, SB203580, a p38 MAPK inhibitor, can alter transcriptional regulation in a way that favors ZNF134's functional activity.
The influence of these compounds extends further with sphingosine-1-phosphate, which modulates sphingolipid signaling, and thapsigargin, which elevates intracellular calcium levels, both potentially enhancing transcriptional pathways influencing ZNF134 expression. Staurosporine, despite being a broad-spectrum kinase inhibitor, could selectively activate pathways associated with ZNF134 by lifting specific kinase-mediated inhibitions. Genistein, as a tyrosine kinase inhibitor, reduces competition in kinase signaling, possibly shifting the equilibrium towards pathways that upregulate ZNF134. Similarly, A23187 enhances ZNF134's activity by increasing intracellular calcium levels, thus activating calcium-dependent signaling pathways crucial for transcriptional regulation. Collectively, these ZNF134 Activators, through targeted effects on cellular signaling, facilitate the enhancement of ZNF134-mediated functions without the need for upregulating its expression or direct activation.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Raises intracellular cAMP levels, activating PKA. PKA phosphorylates transcription factors, potentially upregulating ZNF134 expression due to its role in transcriptional regulation, thereby enhancing ZNF134's functional activity. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
Activates Protein Kinase C (PKC), involved in signaling cascades. This can lead to altered transcription factor activities that enhance ZNF134 expression due to its function in gene regulation. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
Acts as a kinase inhibitor. By inhibiting competitive kinases, pathways that regulate transcription factors influencing ZNF134 expression can be enhanced, thereby indirectly increasing ZNF134's functional activity. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
A PI3K inhibitor. Inhibiting PI3K modulates downstream pathways like AKT, potentially enhancing transcriptional regulation pathways that upregulate ZNF134. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $64.00 $246.00 | 136 | |
A MEK inhibitor. Inhibiting MEK might shift the balance of cellular signaling to pathways that upregulate ZNF134 expression, considering ZNF134's involvement in gene regulation processes. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $90.00 $349.00 | 284 | |
A p38 MAPK inhibitor. This inhibition can alter transcriptional regulation, potentially enhancing the pathways that lead to the upregulation of ZNF134. | ||||||
D-erythro-Sphingosine-1-phosphate | 26993-30-6 | sc-201383 sc-201383D sc-201383A sc-201383B sc-201383C | 1 mg 2 mg 5 mg 10 mg 25 mg | $165.00 $322.00 $570.00 $907.00 $1727.00 | 7 | |
Modulates sphingolipid signaling pathways, which can influence transcriptional regulation. This modulation may indirectly increase ZNF134 activity by enhancing expression pathways pertinent to ZNF134's function in transcription. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $136.00 $446.00 | 114 | |
Elevates intracellular calcium levels, which can activate calcium-dependent signaling pathways. This activation may enhance transcriptional regulation pathways, indirectly boosting ZNF134's functional activity. | ||||||
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $153.00 $396.00 | 113 | |
A broad-spectrum protein kinase inhibitor, might lead to selective activation of pathways related to ZNF134 by lifting the inhibition exerted by specific kinases on processes ZNF134 is involved in, particularly gene regulation. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $45.00 $164.00 $200.00 $402.00 $575.00 $981.00 $2031.00 | 46 | |
A tyrosine kinase inhibitor, reduces competition from tyrosine kinase signaling. This reduction can shift the signaling balance to favor pathways that upregulate ZNF134 expression, considering ZNF134's role in transcriptional regulation. | ||||||