Zip67 Inhibitors
Chemical inhibitors of Zip67 can utilize a variety of signaling pathways to achieve functional inhibition. Staurosporine, a protein kinase C inhibitor, can prevent activation of Zip67 by hindering the phosphorylation events that are crucial for its activity. Similarly, LY294002 and Wortmannin, both PI3K inhibitors, can halt the PI3K-AKT pathway, which is often essential for the function of proteins like Zip67 that might be regulated by PI3K signaling. By obstructing this pathway, these inhibitors can effectively suppress the activity of Zip67. In the same vein, Rapamycin can inhibit the mTOR pathway, which, when active, may serve as a downstream effector for proteins like Zip67. This inhibition can result in the cessation of mTORC1 complex-related processes that are potentially vital for Zip67 function.
Further, targeting the MAPK/ERK pathway with U0126 and PD98059, which are MEK inhibitors, can lead to the inhibition of ERK signaling. Since ERK signaling is a common regulatory mechanism for numerous proteins, the inhibition of this pathway can lead to the functional suppression of Zip67. SB203580, a p38 MAP kinase inhibitor, and SP600125, a JNK inhibitor, both disrupt specific stress response pathways that can be linked to the regulation of Zip67, thereby inhibiting its activity. Y-27632's inhibition of ROCK can impede cytoskeletal reorganization processes that might be essential for Zip67's role in cellular dynamics. Dasatinib, by broadly targeting Src family kinases, can interfere with upstream signaling that could activate Zip67. GW5074 and PD168393, both inhibitors of kinases in the Raf/MEK/ERK and EGFR pathways respectively, can also lead to the disruption of signaling cascades that are possibly crucial for the proper functioning of Zip67.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $153.00 $396.00 | 113 | |
Staurosporine can inhibit protein kinase C (PKC), which is a kinase that could phosphorylate Zip67. Inhibition of PKC would prevent phosphorylation of Zip67, leading to its functional inhibition. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY294002 is a PI3K inhibitor, which prevents the PI3K-AKT pathway activation. Zip67, if reliant on PI3K for signaling, would be functionally inhibited due to the blockade of this pathway. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
Wortmannin is another PI3K inhibitor, similar to LY294002, it would functionally inhibit Zip67 by blocking the PI3K-AKT signaling pathway that Zip67 may utilize for its activation and function. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Rapamycin inhibits mTOR, which is part of the mTORC1 complex, a downstream effector of PI3K-AKT signaling. Inhibition of mTOR could lead to functional inhibition of Zip67 if it is involved in mTORC1 pathway-mediated cellular processes. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $64.00 $246.00 | 136 | |
U0126 is an inhibitor of MEK, which is upstream of ERK in the MAPK/ERK pathway. Functional inhibition of Zip67 could occur if Zip67's activity is dependent on the ERK signaling that U0126 would inhibit. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $40.00 $92.00 | 212 | |
PD98059 also inhibits MEK in the MAPK/ERK pathway, similarly to U0126, possibly leading to functional inhibition of Zip67 by preventing its activation through this pathway. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $90.00 $349.00 | 284 | |
SB203580 is an inhibitor of p38 MAP kinase, which can inhibit signaling pathways involving stress responses that Zip67 might be part of, thus functionally inhibiting Zip67. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 inhibits JNK, which is involved in stress response and apoptosis. Zip67, if involved in JNK-mediated signaling, would be functionally inhibited by the prevention of JNK signaling. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $186.00 $707.00 | 88 | |
Y-27632 is a ROCK inhibitor, which can disrupt cytoskeletal organization. If Zip67 function is associated with cytoskeletal changes mediated by ROCK, then inhibition by Y-27632 would result in functional inhibition of Zip67. | ||||||
Dasatinib | 302962-49-8 | sc-358114 sc-358114A | 25 mg 1 g | $70.00 $145.00 | 51 | |
Dasatinib is a broad-spectrum tyrosine kinase inhibitor that would inhibit Src family kinases. Functional inhibition of Zip67 could occur if Zip67 is activated by Src family kinase signaling, which would be blocked by Dasatinib. | ||||||