ZIP14 Activators
ZIP14 Activators encompass a variety of chemical compounds that indirectly augment the functional activity of ZIP14 through distinct mechanisms related to metal ion homeostasis and transport. Zinc Sulfate and Manganese(II) chloride serve as direct substrates for ZIP14, inherently enhancing its transport capacity by increasing the availability of zinc and manganese ions, respectively, for cellular uptake. Histidine, by forming complexes with zinc, improves the bioavailability of this crucial ion, facilitating more efficient ZIP14-mediated transport. Similarly, Pyrithione Zinc raises intracellular zinc levels, which is expected to accelerate ZIP14 activity. Conversely, Cadmium chloride, while providing cadmium ions, a toxic heavy metal, also interacts with ZIP14, inadvertently enhancing its activity due to the protein's ability to transport diverse metal ions.
Compounds like NAD+, D-Penicillamine, Alpha-Lipoic acid, Trolox, and Resveratrol interplay with ZIP14 activity by modulating metal ion availability and cellular redox states. NAD+ and Alpha-Lipoic acid influence the cellular demand for zinc by altering redox balance, while D-Penicillamine alters metal ion homeostasis, creating a potential increase in the cellular requirement for zinc and manganese ions that ZIP14 can fulfill. Trolox and Resveratrol, through their antioxidant properties, modulate oxidative stress responses, impacting cellular metal ion needs and indirectly enhancing ZIP14's role in zinc transport. Remarkably, EGF, though a biological molecule, signals through pathways that upregulate the cellular demand for zinc, thus indirectly contributing to an increase in ZIP14-mediated zinc uptake, highlighting the interconnected nature of signaling pathways and metal ion transport systems.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Manganese(II) chloride beads | 7773-01-5 | sc-252989 sc-252989A | 100 g 500 g | $19.00 $31.00 | ||
Manganese(II) chloride supplies manganese ions that are substrates for ZIP14. The presence of manganese ions can enhance the transport function of ZIP14 as it also transports manganese, playing a role in cellular manganese homeostasis. | ||||||
L-Histidine | 71-00-1 | sc-394101 sc-394101A sc-394101B sc-394101C sc-394101D | 25 g 100 g 250 g 500 g 1 kg | $54.00 $84.00 $189.00 $204.00 $339.00 | 1 | |
Histidine, an amino acid, forms complexes with zinc ions, which can enhance the zinc transport function of ZIP14 by increasing the bioavailability of zinc for cellular uptake. | ||||||
NAD+, Free Acid | 53-84-9 | sc-208084B sc-208084 sc-208084A sc-208084C sc-208084D sc-208084E sc-208084F | 1 g 5 g 10 g 25 g 100 g 1 kg 5 kg | $57.00 $191.00 $302.00 $450.00 $1800.00 $3570.00 $10710.00 | 4 | |
NAD+ is involved in redox reactions within the cell. By influencing redox status, NAD+ can modulate the metal ion homeostasis, indirectly enhancing the activity of ZIP14 as it transports zinc, which is crucial for maintaining the redox balance in cells. | ||||||
Zinc | 7440-66-6 | sc-213177 | 100 g | $48.00 | ||
Zinc sulfate provides zinc ions, which directly enhance the function of ZIP14 by increasing its zinc transport activity. ZIP14 is a zinc transporter, and the presence of zinc ions is crucial for its functional activity in cellular zinc uptake. | ||||||
Cadmium chloride, anhydrous | 10108-64-2 | sc-252533 sc-252533A sc-252533B | 10 g 50 g 500 g | $56.00 $183.00 $352.00 | 1 | |
Cadmium chloride provides cadmium ions, which are also substrates for ZIP14. By increasing the concentration of cadmium ions, it can enhance the transport function of ZIP14, which is known to transport cadmium as well. | ||||||
Penicillamine | 52-67-5 | sc-205795 sc-205795A | 1 g 5 g | $46.00 $96.00 | ||
D-Penicillamine chelates copper and can indirectly enhance ZIP14 activity by altering metal ion homeostasis in the cell, potentially increasing the need for zinc transport through ZIP14. | ||||||
α-Lipoic Acid | 1077-28-7 | sc-202032 sc-202032A sc-202032B sc-202032C sc-202032D | 5 g 10 g 250 g 500 g 1 kg | $69.00 $122.00 $212.00 $380.00 $716.00 | 3 | |
Alpha-Lipoic acid is known to influence cellular antioxidant status, which can indirectly enhance the activity of ZIP14 by modulating the cellular demand for zinc, a crucial ion for antioxidant enzyme function. | ||||||
Trolox | 53188-07-1 | sc-200810 sc-200810A sc-200810B sc-200810C sc-200810D | 500 mg 1 g 5 g 25 g 100 g | $38.00 $67.00 $235.00 $678.00 $1712.00 | 39 | |
Trolox, a vitamin E analog, serves as an antioxidant, modulating oxidative stress and influencing the homeostasis of metal ions such as zinc, indirectly enhancing ZIP14 activity by potentially increasing the cellular demand for zinc transport. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol influences a variety of signaling pathways, including those related to cellular metal ion homeostasis. By altering these pathways, it could indirectly enhance the functional activity of ZIP14, which is responsible for zinc transport into cells. | ||||||