WFDC10 Inhibitors
WFDC10 inhibitors pertain to a category of chemical agents that specifically interact with and inhibit the activity of the protein known as WFDC10. The acronym WFDC stands for WAP (Whey Acidic Protein) Four-Disulfide Core domain, which is a characteristic feature of this group of proteins. The WFDC domain is integral to the functional conformation of these proteins, which typically includes a compact structure stabilized by disulfide bonds. Inhibitors targeting WFDC10 are designed to bind to this protein, affecting its stability or interfering with its capacity to engage in normal biological processes. The precise mechanism of inhibition can vary, ranging from direct interaction with the active site to allosteric modulation, wherein the inhibitor binds to a site distinct from the active region, inducing a conformational change that diminishes the protein's activity.
The design of WFDC10 inhibitors is a sophisticated process that often relies on understanding the three-dimensional structure of the protein and the key interactions that are essential for its function. Scientists may utilize various techniques such as crystallography, computational modeling, and mutational analysis to identify crucial regions of the protein that are amenable to inhibition. The WFDC10 protein itself is part of a larger family of WFDC proteins, which are known to play roles in processes that involve protein-protein interactions due to their stable structure and potential to bind to various ligands. Inhibitors in this class are typically small molecules or peptides that can robustly bind to WFDC10 with high specificity, thereby achieving selective inhibition. Research into the development of these inhibitors is driven by an interest in elucidating the biological role of WFDC10 and understanding how its function can be modulated by small molecule interactions.
SEE ALSO...
Items 1 to 10 of 12 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Cycloheximide | 66-81-9 | sc-3508B sc-3508 sc-3508A | 100 mg 1 g 5 g | $40.00 $82.00 $256.00 | 127 | |
This compound inhibits protein biosynthesis by interfering with the translocation step in protein synthesis on the ribosome. This action would decrease the overall protein levels, including those of WFDC10, by preventing its synthesis. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
A potent inhibitor of PI3K, LY294002 blocks the PI3K/Akt signaling pathway, which is critical for cell survival and growth. Inhibition of this pathway can lead to reduced transcriptional activity affecting proteins like WFDC10. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin selectively inhibits mTOR, a key regulator of cell growth and proliferation. By inhibiting mTOR, rapamycin can reduce protein synthesis and thus decrease the levels of proteins such as WFDC10. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
This compound is a selective inhibitor of MEK, which in turn inhibits the ERK/MAPK pathway. By blocking this signaling cascade, PD98059 can impair cellular responses that may regulate the expression or activity of WFDC10. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
Similar to PD98059, U0126 is a MEK inhibitor that prevents the activation of the MAPK/ERK pathway, potentially reducing the expression or activity of proteins like WFDC10 that are regulated by this pathway. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB203580 specifically inhibits p38 MAPK, affecting inflammatory responses and cell differentiation. Disruption of this pathway can indirectly decrease the expression or activation of proteins like WFDC10 that may be downstream effectors. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
As an inhibitor of PI3K, wortmannin disrupts the PI3K/Akt pathway, leading to potential suppression of proteins that rely on this pathway for expression or activation, such as WFDC10. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $65.00 $267.00 | 257 | |
An inhibitor of JNK signaling, SP600125 may impede pathways involved in cell stress responses. By doing so, it could indirectly affect the expression level or function of WFDC10 if it is part of the response mediated by this pathway. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
Trichostatin A is a histone deacetylase inhibitor that alters chromatin structure and gene expression. This epigenetic modification can lead to the downregulation of various proteins, including potentially WFDC10. | ||||||
Bortezomib | 179324-69-7 | sc-217785 sc-217785A | 2.5 mg 25 mg | $132.00 $1064.00 | 115 | |
Bortezomib is a proteasome inhibitor that leads to the accumulation of polyubiquitinated proteins, inducing cell cycle arrest and apoptosis. This disruption can reduce the levels of proteins such as WFDC10. | ||||||