WDR43 Inhibitors
WDR43 inhibitors belong to a class of chemical compounds that are designed to interact with WD repeat domain 43 (WDR43), a protein that plays a critical role in the cellular machinery of organisms. WDR43 is characterized by the presence of WD repeats, which are short amino acid motifs that end with tryptophan-aspartic acid (W-D) and are involved in a variety of protein-protein interactions. The structure of WDR43 is such that it can form a beta-propeller shape, which facilitates its interaction with other proteins and possibly RNA. Inhibitors targeting WDR43 are specifically designed to bind to this protein and disrupt its normal function by preventing it from engaging in its usual biological processes.
The development and interest in WDR43 inhibitors stem from the protein's involvement in fundamental biological functions. By inhibiting WDR43, these compounds affect the protein's role in cellular processes. The molecular design of these inhibitors is often based on the understanding of the three-dimensional structure of WDR43, allowing for a high degree of specificity in the interaction. These inhibitors can be small molecules that precisely fit into the protein's active or binding sites, or they could be larger biomolecules that interfere with WDR43's ability to form complexes with other proteins or RNA. The study of WDR43 inhibitors is a field that combines aspects of organic chemistry, biochemistry, and molecular biology, involving techniques such as high-throughput screening, and computational modeling to identify and optimize potential inhibitors with high affinity and specificity for the WDR43 protein.
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Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
An inhibitor of mTOR (mammalian target of rapamycin), which is involved in mRNA translation and cell growth. WDR43 is part of the U5 snRNP complex which is involved in pre-mRNA splicing; inhibiting mTOR can result in reduced cell growth and proliferation, thereby indirectly affecting the splicing activity in which WDR43 is involved. | ||||||
Leptomycin B | 87081-35-4 | sc-358688 sc-358688A sc-358688B | 50 µg 500 µg 2.5 mg | $107.00 $416.00 $1248.00 | 35 | |
An inhibitor of CRM1 (exportin 1), which is involved in the nuclear export of proteins and RNAs, including ribonucleoprotein particles. By inhibiting CRM1, Leptomycin B could indirectly influence the nuclear-cytoplasmic trafficking of WDR43-containing complexes, affecting its functionality. | ||||||
Pladienolide B | 445493-23-2 | sc-391691 sc-391691B sc-391691A sc-391691C sc-391691D sc-391691E | 0.5 mg 10 mg 20 mg 50 mg 100 mg 5 mg | $299.00 $5699.00 $11099.00 $25500.00 $66300.00 $2875.00 | 63 | |
A specific inhibitor of the spliceosome, targeting the SF3b complex. WDR43 is associated with the U5 snRNP, and inhibition of the spliceosome could indirectly affect WDR43's role in splicing. | ||||||
Triptolide | 38748-32-2 | sc-200122 sc-200122A | 1 mg 5 mg | $90.00 $204.00 | 13 | |
An inhibitor of RNA polymerase II, leading to decreased transcription. Since WDR43 is involved in pre-mRNA splicing, the reduced transcription of pre-mRNA would indirectly decrease the demand for WDR43's splicing activity. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $64.00 $246.00 | 136 | |
An inhibitor of MEK, which acts upstream of ERK in the MAPK pathway. While not directly linked to WDR43, the MAPK pathway influences numerous cellular processes including gene expression and cell cycle progression, which could indirectly affect WDR43's function in splicing by altering the cellular environment. | ||||||
Bortezomib | 179324-69-7 | sc-217785 sc-217785A | 2.5 mg 25 mg | $135.00 $1085.00 | 115 | |
A proteasome inhibitor that can lead to increased cellular stress and unfolded protein response. This can indirectly affect the splicing machinery where WDR43 operates by disrupting the overall protein homeostasis in the cell. | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $60.00 $265.00 $1000.00 | 163 | |
A proteasome inhibitor similar to Bortezomib, affecting protein turnover and inducing stress responses that could indirectly affect the splicing machinery involving WDR43. | ||||||
Spliceostatin A | 391611-36-2 | sc-507481 | 1 mg | $1800.00 | ||
A compound that inhibits splicing by binding to the SF3b complex of the spliceosome. This would indirectly affect WDR43's role in splicing by inhibiting the spliceosome functionality. | ||||||
Homoharringtonine | 26833-87-4 | sc-202652 sc-202652A sc-202652B | 1 mg 5 mg 10 mg | $52.00 $125.00 $182.00 | 11 | |
An inhibitor of protein synthesis at the initiation step of translation. Since WDR43 is involved in mRNA processing, reduced translation efficiency could indirectly reduce the functional need for WDR43's activity. | ||||||
Sodium (meta)arsenite | 7784-46-5 | sc-250986 sc-250986A | 100 g 1 kg | $108.00 $780.00 | 3 | |
Induces heat shock protein expression and stress granule formation. This stress response can alter RNA metabolism and splicing processes, potentially affecting WDR43's role in the spliceosome. | ||||||