WDR31 Inhibitors
Inhibitors of WDR31 function by modulating various signaling pathways and cellular processes that WDR31 is implicated in, without directly targeting the protein itself. For example, the inhibition of mTOR signaling can lead to reduced protein synthesis and cellular proliferation, which indirectly reduces the functional activity of WDR31 if it plays a role in these cellular processes. Similarly, the disruption of the PI3K/AKT/mTOR cascade, a critical pathway for cell survival, can lead to a decrease in activities where WDR31 is functionally relevant, by hindering the signals that guide these survival mechanisms. The use of MEK inhibitors can affect the MAPK/ERK pathway, involved in cell proliferation and survival, altering cellular signaling dynamics and potentially impacting the functional role of WDR31 within these pathways. Inhibition of p38 MAPK affects stress and inflammatory responses, as well as apoptosis, thus influencing WDR31's functions tied to these cellular responses. Additionally, the JNK signaling pathway, when interrupted, affects apoptosis and other cellular processes, which could in turn modify WDR31's role within these pathways.
Other inhibitors target pathways involved in more specialized cellular contexts where WDR31 may play a part. Cyclopamine, for instance, impedes the Hedgehog pathway, which is essential for cell differentiation and tissue patterning, affecting the functional role of WDR31 in these biological processes. Inhibitors of VEGFR block the VEGF pathway, which is crucial for angiogenesis and cell migration, potentially altering WDR31 activity in related phenomena. Furthermore, the targeting of Rho/ROCK pathway by specific inhibitors affects cytoskeletal dynamics and cell motility, indirectly affecting WDR31 activity.
SEE ALSO...
Items 1 to 10 of 12 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
An mTOR inhibitor that impedes the mTOR pathway, a signaling route critical for protein synthesis and cellular growth regulation, thus indirectly leading to the functional inhibition of WDR31 by reducing processes that require mTOR signaling. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
A PI3K inhibitor that hinders the PI3K/AKT/mTOR signaling cascade, which is essential for cell survival and growth, consequently causing a decrease in activities where WDR31 may be functionally relevant. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
An MEK inhibitor that disrupts the MAPK/ERK pathway, which is involved in cell proliferation and survival, potentially affecting WDR31 activity due to altered signaling dynamics. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
A p38 MAPK inhibitor which blocks the p38 MAPK pathway involved in stress responses, inflammatory responses, and apoptosis, thereby influencing WDR31 functions tied to these processes. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $65.00 $267.00 | 257 | |
An inhibitor of JNK that interrupts the JNK signaling involved in apoptosis and other cellular processes, which could in turn affect WDR31's role in these pathways. | ||||||
Cyclopamine | 4449-51-8 | sc-200929 sc-200929A | 1 mg 5 mg | $92.00 $204.00 | 19 | |
A Hedgehog signaling pathway inhibitor that impedes the pathway crucial for cell differentiation and tissue patterning, potentially impacting WDR31's functional role in these biological processes. | ||||||
Vandetanib | 443913-73-3 | sc-220364 sc-220364A | 5 mg 50 mg | $167.00 $1353.00 | ||
A VEGFR inhibitor that blocks the VEGF pathway important for angiogenesis and cell migration, possibly influencing WDR31 activity in these cellular phenomena. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $182.00 $693.00 | 88 | |
A ROCK inhibitor that attenuates the Rho/ROCK pathway, which is key for cytoskeletal dynamics and cell motility, indirectly affecting WDR31 if involved in these cellular functions. | ||||||
Bortezomib | 179324-69-7 | sc-217785 sc-217785A | 2.5 mg 25 mg | $132.00 $1064.00 | 115 | |
A proteasome inhibitor that prevents the degradation of ubiquitinated proteins, potentially impacting WDR31 by altering the protein turnover and signaling pathways reliant on proteasomal degradation. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
A histone deacetylase inhibitor that influences gene expression by altering chromatin structure, which could lead to differential regulation of proteins including WDR31, depending on its expression regulation. | ||||||