VSX1 Activators
VSX1 Activators is a chemical class that represents a group of compounds designed to target the VSX1 gene, also known as Visual System Homeobox 1. The VSX1 gene encodes a transcription factor that plays a crucial role in the development and maintenance of the eye, particularly in the differentiation and function of the corneal epithelium, which is the outermost layer of the cornea. VSX1 is a homeobox gene, a type of gene that regulates the expression of other genes, and mutations or dysregulation in VSX1 have been associated with various eye disorders, such as keratoconus, a condition characterized by the progressive thinning and bulging of the cornea. VSX1 Activators, therefore, have a primary aim to modulate the activity of VSX1 gene and its downstream targets, potentially influencing the corneal development and function.
These activators work at the molecular level by binding to specific regions of the VSX1 gene or its associated regulatory elements. By binding to these specific sites, they can enhance the transcriptional activity of VSX1, leading to an increased expression of VSX1 protein. This, in turn, may promote normal corneal development, differentiation, and maintenance. The detailed mechanism of action of VSX1 Activators involves the regulation of various signaling pathways and gene networks associated with eye development, with the ultimate goal of maintaining corneal integrity and function.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
A derivative of vitamin A that indirectly activates VSX1 by orchestrating genes involved in eye development through retinoic acid receptors (RARs) and retinoid X receptors (RXRs). | ||||||
SB 431542 | 301836-41-9 | sc-204265 sc-204265A sc-204265B | 1 mg 10 mg 25 mg | $80.00 $212.00 $408.00 | 48 | |
An inhibitor of the TGF-β signaling pathway that indirectly triggers activation of VSX1. TGF-β inhibition can activate cellular processes associated with eye development, potentially leading to VSX1 expression. | ||||||
Cyclopamine | 4449-51-8 | sc-200929 sc-200929A | 1 mg 5 mg | $92.00 $204.00 | 19 | |
A natural compound that indirectly activates VSX1 by inhibiting the Sonic Hedgehog (SHH) pathway, which is involved in eye development. | ||||||
PD173074 | 219580-11-7 | sc-202610 sc-202610A sc-202610B | 1 mg 5 mg 50 mg | $46.00 $140.00 $680.00 | 16 | |
An inhibitor of FGF signaling that can indirectly activate VSX1. FGFs play a role in eye development, and inhibiting this pathway may activate VSX1 expression. | ||||||
DAPT | 208255-80-5 | sc-201315 sc-201315A sc-201315B sc-201315C | 5 mg 25 mg 100 mg 1 g | $99.00 $335.00 $836.00 $2099.00 | 47 | |
A compound that indirectly activates VSX1 by modulating the Notch pathway, a key regulator in eye development and potential upstream activator of VSX1 expression. | ||||||
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $76.00 $82.00 $367.00 | 36 | |
A synthetic steroid that can directly activate VSX1 by reducing inflammation and activating pathways associated with eye conditions in which inflammation is a component. | ||||||
N-Acetyl-L-cysteine | 616-91-1 | sc-202232 sc-202232A sc-202232C sc-202232B | 5 g 25 g 1 kg 100 g | $33.00 $73.00 $265.00 $112.00 | 34 | |
An antioxidant that can indirectly activate VSX1 by mitigating oxidative stress, which can activate eye health and related signaling pathways. | ||||||
Diclofenac acid | 15307-86-5 | sc-357332 sc-357332A | 5 g 25 g | $107.00 $292.00 | 5 | |
An anti-inflammatory compound that can directly or indirectly activate VSX1 by modulating inflammatory processes associated with certain eye conditions. | ||||||