VPS52 Activators
Vacuolar Protein Sorting 52 (VPS52) is a protein encoded by the VPS52 gene in humans. It's a part of the Golgi-associated retrograde protein (GARP) complex, which consists of four subunits: VPS51, VPS52, VPS53, and VPS54.The GARP complex, including VPS52, plays a critical role in the retrograde transport of proteins from endosomes to the trans-Golgi network (TGN). This process facilitates the recycling of proteins within the cell, which is essential for maintaining cellular homeostasis. Disruptions in this pathway can lead to cellular malfunction and contribute to diseases.
VPS52, like other components of the GARP complex, is necessary for the tethering and fusion of transport vesicles to their target compartments. This function is crucial for the proper sorting and delivery of proteins within the cell.In addition to its role in vesicle transport, VPS52 has been implicated in other cellular processes. It has been identified as a regulator of WASH complex assembly, which is important for actin polymerization and endosomal cargo sorting.In summary, VPS52 is an essential component of the GARP complex, involved in protein sorting and vesicle transport within the cell. Its role in these processes makes it crucial for maintaining normal cellular function, and further research may uncover its involvement in disease mechanisms.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Monensin A | 17090-79-8 | sc-362032 sc-362032A | 5 mg 25 mg | $155.00 $525.00 | ||
Monensin, an ionophore that disrupts lysosomal function, can indirectly influence VPS52 by affecting endosomal-lysosomal trafficking. | ||||||
Bafilomycin A1 | 88899-55-2 | sc-201550 sc-201550A sc-201550B sc-201550C | 100 µg 1 mg 5 mg 10 mg | $98.00 $255.00 $765.00 $1457.00 | 280 | |
Known as a vacuolar-type H+-ATPase inhibitor, Bafilomycin A1 can indirectly affect VPS52 activity by impacting endosomal acidification and trafficking. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Primarily an mTOR inhibitor, Rapamycin can indirectly influence VPS52 activity by affecting autophagy, a process interconnected with endosomal-lysosomal trafficking. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
A PI3K inhibitor, Wortmannin might indirectly affect VPS52 by influencing pathways related to vesicular trafficking and autophagy. | ||||||
Vinblastine | 865-21-4 | sc-491749 sc-491749A sc-491749B sc-491749C sc-491749D | 10 mg 50 mg 100 mg 500 mg 1 g | $102.00 $235.00 $459.00 $1749.00 $2958.00 | 4 | |
As a microtubule-disrupting agent, Vinblastine can indirectly affect VPS52 by altering cellular transport mechanisms. | ||||||
D-(+)-Trehalose Anhydrous | 99-20-7 | sc-294151 sc-294151A sc-294151B | 1 g 25 g 100 g | $30.00 $167.00 $260.00 | 2 | |
Trehalose, known for its role in autophagy induction, may indirectly affect VPS52 activity by influencing autophagic-lysosomal pathways. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
As an inhibitor of GSK-3β, Lithium Chloride can indirectly affect VPS52 by influencing pathways related to vesicle transport and autophagy. | ||||||