VPS37D Inhibitors
VPS37D Inhibitors would be a group of chemical compounds designed to selectively modulate the activity or interactions of VPS37D within the ESCRT-III complex. These compounds could target specific binding sites or domains of VPS37D that are crucial for its function in cellular processes such as endosomal sorting, membrane abscission, and other membrane remodeling events. Given that VPS37D plays a role in mediating protein-protein interactions within the ESCRT machinery, inhibitors could be designed to disrupt these interactions, affecting the formation or stability of the ESCRT-III complex.
Chemically, VPS37D Inhibitors might comprise a diverse range of structures, such as small molecules or peptides, designed to interfere with the functions of VPS37D. They could function by binding to key regions of the protein that are essential for its role in endosomal sorting and membrane remodeling. Alternatively, they might impact the dynamics of the larger ESCRT-III complex by influencing the assembly, disassembly, or stability of VPS37D interactions with other subunits. The design of such inhibitors would require a comprehensive understanding of the structural biology of VPS37D and its interactions within the ESCRT machinery.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Doxorubicin | 23214-92-8 | sc-280681 sc-280681A | 1 mg 5 mg | $173.00 $418.00 | 43 | |
Doxorubicin has been shown to interact with components of the ESCRT machinery, which could potentially impact VPS37D-associated functions. | ||||||
p53 Activator III, RITA | 213261-59-7 | sc-202753 sc-202753A sc-202753B sc-202753C | 1 mg 10 mg 100 mg 500 mg | $110.00 $268.00 $1533.00 $5103.00 | 9 | |
This compound has been investigated for its potential to inhibit ESCRT-III components, which might include VPS37D, and thus affect endosomal sorting processes. | ||||||
MRT 68921 | 1190379-70-4 | sc-507429 | 10 mg | $276.00 | ||
MRT 68921 is an inhibitor of the AAA ATPase VPS4, which is part of the ESCRT machinery. It could influence the dynamics of ESCRT-III and, by extension, VPS37D. | ||||||
MLN 4924 | 905579-51-3 | sc-484814 | 1 mg | $280.00 | 1 | |
Although primarily known as a NEDD8-activating enzyme (NAE) inhibitor, MLN4924 has been reported to influence ESCRT-dependent processes, potentially involving VPS37D. | ||||||
Methylstat | 1310877-95-2 | sc-507374 | 10 mg | $480.00 | ||
Methylstat is an inhibitor of the AAA ATPase VPS4 that could potentially disrupt ESCRT-mediated processes involving VPS37D. | ||||||
NSC 185058 | 39122-38-8 | sc-507531 | 1 mg | $85.00 | ||
This compound has been explored for its effects on endosomal trafficking and could potentially impact the functions of VPS37D and other ESCRT-III components. | ||||||