VPS13C Activators
VPS13C Activators encompass a diverse set of chemical compounds that boost VPS13C's role in lipid transport, autophagy, and membrane maintenance through specific cellular mechanisms. Phosphatidic acid and ceramide, by altering the lipid composition of cellular membranes, provide a conducive environment for VPS13C to operate more effectively. Additionally, Nicotinamide adenine dinucleotide (NAD+) can increase VPS13C's functionality via sirtuin-mediated deacetylation, while sphingosine-1-phosphate and lysophosphatidylcholine modulate autophagy and membrane dynamics to enhance VPS13C activity. Cholesterol transport inhibitor U18666A, by disrupting cholesterol homeostasis, could inadvertently trigger a compensatory activation of VPS13C, and cardiolipin may bolster VPS13C's interaction with mitochondrial membranes, thus enhancing its activity. Furthermore, PIP2 is instrumental in signal transduction and may impact VPS13C activity by influencing membrane-associated functions, particularly in autophagy.
Arachidonic acid and oleic acid are fatty acids that integrate into cellular membranes, altering their fluidity and composition, which can, in turn, activate VPS13C's lipid transport function. Curcumin and resveratrol both engage with cellular signaling pathways; curcumin enhances VPS13C activity by modulating autophagic signaling, and resveratrol activates VPS13C through sirtuin-mediated pathways related to cellular stress responses.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Phosphatidic Acid, Dipalmitoyl | 169051-60-9 | sc-201057 sc-201057B sc-201057A | 100 mg 250 mg 500 mg | $106.00 $244.00 $417.00 | ||
Phosphatidic acid interacts with lipid-binding domains, which can affect membrane-associated proteins. VPS13C, being associated with lipid transport and autophagy, can be activated by changes in lipid membrane composition, therefore phosphatidic acid can enhance VPS13C activity by influencing the lipid membranes where VPS13C operates. | ||||||
C2 Ceramide | 3102-57-6 | sc-201375 sc-201375A | 5 mg 25 mg | $124.00 $460.00 | 12 | |
Ceramide is involved in the sphingolipid signaling pathway. It can induce autophagy by impacting the lipid composition of cellular membranes and can therefore increase the activation of VPS13C, which is implicated in the autophagic process. | ||||||
NAD+, Free Acid | 53-84-9 | sc-208084B sc-208084 sc-208084A sc-208084C sc-208084D sc-208084E sc-208084F | 1 g 5 g 10 g 25 g 100 g 1 kg 5 kg | $57.00 $191.00 $302.00 $450.00 $1800.00 $3570.00 $10710.00 | 4 | |
NAD+ serves as a substrate for sirtuins, which can deacetylate proteins and affect their activity. VPS13C has been suggested to be regulated by acetylation status; thus, increased NAD+ levels could enhance VPS13C function through sirtuin-mediated deacetylation. | ||||||
D-erythro-Sphingosine-1-phosphate | 26993-30-6 | sc-201383 sc-201383D sc-201383A sc-201383B sc-201383C | 1 mg 2 mg 5 mg 10 mg 25 mg | $165.00 $322.00 $570.00 $907.00 $1727.00 | 7 | |
Sphingosine-1-phosphate modulates autophagy and membrane dynamics. VPS13C function in autophagy and membrane maintenance could be enhanced by S1P through its role in signaling pathways that govern these processes. | ||||||
U 18666A | 3039-71-2 | sc-203306 sc-203306A | 10 mg 50 mg | $143.00 $510.00 | 2 | |
U18666A is a cholesterol transport inhibitor that affects intracellular cholesterol distribution. VPS13C, with functions in lipid transport, may be activated to compensate for the disrupted cholesterol homeostasis, indirectly increasing its activity. | ||||||
Arachidonic Acid (20:4, n-6) | 506-32-1 | sc-200770 sc-200770A sc-200770B | 100 mg 1 g 25 g | $92.00 $240.00 $4328.00 | 9 | |
Arachidonic acid serves as a precursor for eicosanoids and modulates inflammatory responses. It may enhance VPS13C activity indirectly by altering membrane lipid composition and signaling pathways associated with inflammation and autophagy. | ||||||
Oleic Acid | 112-80-1 | sc-200797C sc-200797 sc-200797A sc-200797B | 1 g 10 g 100 g 250 g | $37.00 $104.00 $580.00 $1196.00 | 10 | |
Oleic acid is a fatty acid that integrates into cellular membranes, affecting their fluidity and function. VPS13C could be activated by changes in membrane fluidity that oleic acid induces, enhancing its lipid transport activity. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin affects various signaling pathways including those related to autophagy. By modulating autophagic signaling, curcumin could enhance the activity of VPS13C, which is involved in the autophagic process. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol influences sirtuin activity and other pathways involved in cellular stress responses. As VPS13C is associated with cellular stress response mechanisms, resveratrol could enhance VPS13C function through sirtuin-mediated pathways. | ||||||