Vmn2r79 Activators
Chemical activators of Vmn2r79 initiate their effects through various signaling pathways that converge on the modulation of the protein's activity. Isoproterenol, epinephrine, serotonin, dopamine, acetylcholine, adenosine, histamine, and glucagon share a common mechanism where they bind to their respective G-protein coupled receptors (GPCRs). This interaction stimulates the enzyme adenylate cyclase, which catalyzes the conversion of ATP to cyclic AMP (cAMP). The increase in cAMP levels leads to the activation of protein kinase A (PKA). Once activated, PKA phosphorylates Vmn2r79, thereby modulating its activity. Forskolin, while not binding to a receptor, directly activates adenylate cyclase, also leading to increased cAMP and subsequent PKA activation, resulting in the phosphorylation of Vmn2r79.
On the other hand, arginine vasopressin, oxytocin, and angiotensin II engage Vmn2r79 through a slightly different pathway. They bind to their respective receptors, which activates phospholipase C (PLC). PLC cleaves phosphatidylinositol 4,5-bisphosphate (PIP2) into diacylglycerol (DAG) and inositol 1,4,5-triphosphate (IP3). IP3 triggers the release of calcium ions from intracellular stores, while DAG activates protein kinase C (PKC). PKC then phosphorylates Vmn2r79, leading to its activation. This pathway, involving calcium ion release and PKC activation, offers an alternative route to modulate the activity of Vmn2r79, demonstrating the diverse mechanisms through which this protein can be regulated.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $28.00 $38.00 | 5 | |
Isoproterenol activates beta-adrenergic receptors, leading to the activation of adenylate cyclase and an increase in cAMP levels. This elevation in cAMP can activate PKA, which subsequently phosphorylates and activates Vmn2r79 through downstream signaling pathways. | ||||||
Serotonin hydrochloride | 153-98-0 | sc-201146 sc-201146A | 100 mg 1 g | $118.00 $187.00 | 15 | |
Serotonin binds to its G-protein coupled receptors, which can activate adenylate cyclase. The subsequent increase in cAMP levels activates PKA, leading to the phosphorylation and activation of Vmn2r79. | ||||||
Dopamine | 51-61-6 | sc-507336 | 1 g | $290.00 | ||
Dopamine interacts with its specific G-protein coupled receptors to activate adenylate cyclase. The increase in cAMP and subsequent activation of PKA can lead to the phosphorylation and activation of Vmn2r79. | ||||||
Adenosine | 58-61-7 | sc-291838 sc-291838A sc-291838B sc-291838C sc-291838D sc-291838E sc-291838F | 1 g 5 g 100 g 250 g 1 kg 5 kg 10 kg | $34.00 $48.00 $300.00 $572.00 $1040.00 $2601.00 $4682.00 | 1 | |
Adenosine can activate A2A receptors, which in turn activate adenylate cyclase. The increase in cAMP levels activates PKA, and this can lead to the phosphorylation and activation of Vmn2r79. | ||||||
Histamine, free base | 51-45-6 | sc-204000 sc-204000A sc-204000B | 1 g 5 g 25 g | $94.00 $283.00 $988.00 | 7 | |
Histamine binds to H2 receptors that activate adenylate cyclase, resulting in increased levels of cAMP. The activation of PKA by cAMP can then phosphorylate and activate Vmn2r79. | ||||||
Arginine vasopressin | 113-79-1 | sc-507381 | 100 mg | $810.00 | ||
Arginine vasopressin binds to its V1a or V2 receptors, which can activate phospholipase C (PLC). PLC activation leads to IP3 and DAG production, which results in calcium release and PKC activation. PKC can then phosphorylate and activate Vmn2r79. | ||||||
Oxytocin acetate salt | 50-56-6 | sc-279938 sc-279938A sc-279938B sc-279938C sc-279938D sc-279938E | 1 mg 5 mg 25 mg 100 mg 250 mg 1 g | $60.00 $180.00 $337.00 $663.00 $969.00 $1836.00 | 4 | |
Oxytocin interacts with its receptors to activate PLC, resulting in the production of IP3 and DAG. This leads to the activation of PKC, which can phosphorylate and activate Vmn2r79. | ||||||
Angiotensin II, Human | 4474-91-3 | sc-363643 sc-363643A sc-363643B sc-363643C | 1 mg 5 mg 25 mg 100 mg | $51.00 $100.00 $310.00 $690.00 | 3 | |
Angiotensin II binds to AT1 receptors, which activate PLC. The production of IP3 and DAG by PLC can lead to the activation of PKC, and PKC can phosphorylate and activate Vmn2r79. | ||||||
(−)-Epinephrine | 51-43-4 | sc-205674 sc-205674A sc-205674B sc-205674C sc-205674D | 1 g 5 g 10 g 100 g 1 kg | $41.00 $104.00 $201.00 $1774.00 $16500.00 | ||
Epinephrine interacts with beta-adrenergic receptors, which activate adenylate cyclase. Increased cAMP levels lead to the activation of PKA, and PKA can phosphorylate and subsequently activate Vmn2r79. | ||||||