Vmn2r58 Inhibitors
Vmn2r58 function by interfering with various molecular pathways and processes that are essential for the normal activity of the protein. 2-Methoxyestradiol acts by targeting the angiogenesis process, which could be crucial for the sustenance of tissues where Vmn2r58 is active. This chemical's action might reduce the vascular support necessary for the proper functioning of Vmn2r58, potentially leading to a compromised state where the protein is unable to carry out its role effectively due to a lack of nutrients and oxygen. Similarly, Brefeldin A disrupts the protein transport within cells by inhibiting the Golgi apparatus. This disruption can prevent Vmn2r58 from reaching its intended cellular location, thereby inhibiting its activity by causing mislocalization. Genistein and Gö6976, which are tyrosine kinase and protein kinase C (PKC) inhibitors, respectively, can impede the phosphorylation of proteins and signaling events that are likely important for Vmn2r58 function. By preventing these phosphorylation events, Genistein and Gö6976 can inhibit the signaling pathways upon which Vmn2r58 depends.
LY294002 and Wortmannin, both phosphoinositide 3-kinase (PI3K) inhibitors, can impair the PI3K signaling cascade that Vmn2r58 may utilize for its function. The disruption brought about by these inhibitors can lead to a decrease in the activity of Vmn2r58 due to the blocking of downstream signals. PD98059 and SB203580, targeting the mitogen-activated protein kinase (MAPK/ERK) and p38 MAPK, respectively, can inhibit pathways that could be instrumental for the signaling and subsequent function of Vmn2r58. U73122, by inhibiting phospholipase C (PLC), can disrupt the generation of second messengers that facilitate Vmn2r58 signaling, while Rapamycin, an mTOR inhibitor, can affect downstream signaling processes that are potentially linked to Vmn2r58's function. Y-27632, a Rho-associated protein kinase (ROCK) inhibitor, can impair signaling pathways that intersect with those involving Vmn2r58, leading to inhibited function. Lastly, Gefitinib, by inhibiting the epidermal growth factor receptor (EGFR) tyrosine kinase, can affect signaling events that Vmn2r58 may depend upon, thereby reducing the activity of the protein. Each of these chemicals, through their targeted actions, can alter the functional state of Vmn2r58 by disrupting the necessary cellular signals and processes.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
2-Methoxyestradiol | 362-07-2 | sc-201371 sc-201371A | 10 mg 50 mg | $70.00 $282.00 | 6 | |
2-Methoxyestradiol inhibits angiogenesis, which is a process that Vmn2r58 may rely on for proper function, particularly if Vmn2r58 plays a role in vascularized tissues. This chemical's inhibition of angiogenesis can lead to a reduction in blood flow, potentially impairing the function of Vmn2r58 by depriving it of necessary nutrients and oxygen. | ||||||
Brefeldin A | 20350-15-6 | sc-200861C sc-200861 sc-200861A sc-200861B | 1 mg 5 mg 25 mg 100 mg | $30.00 $52.00 $122.00 $367.00 | 25 | |
Brefeldin A interferes with protein transport by inhibiting the function of the Golgi apparatus. As Vmn2r58 is a protein that requires proper trafficking to the cell membrane to function, Brefeldin A's action would result in the mislocalization of Vmn2r58, thereby functionally inhibiting its activity. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $26.00 $92.00 $120.00 $310.00 $500.00 $908.00 $1821.00 | 46 | |
Genistein is a tyrosine kinase inhibitor and may inhibit the phosphorylation of proteins that interact with Vmn2r58, which could be crucial for its function. The inhibition of these phosphorylation events would disrupt signaling pathways essential for Vmn2r58's activity, leading to its functional inhibition. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a phosphoinositide 3-kinase (PI3K) inhibitor. If Vmn2r58 relies on PI3K signaling for its function, LY294002 would inhibit this signaling pathway, thereby impairing Vmn2r58's functional activity. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD98059 is an inhibitor of mitogen-activated protein kinase (MAPK/ERK), which may be part of the signaling cascade that Vmn2r58 engages in. Inhibition of this pathway by PD98059 could lead to reduced activity of Vmn2r58 as a result of impaired signal transduction. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB203580 is a p38 MAPK inhibitor, which could be involved in the signaling pathways that Vmn2r58 participates in. Inhibiting p38 MAPK would disrupt this pathway and thereby inhibit the function of Vmn2r58. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin is another PI3K inhibitor that would prevent the activation of downstream signaling required for Vmn2r58 function. The inhibition of PI3K by Wortmannin would lead to a decrease in Vmn2r58 activity. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin inhibits mTOR, which could be a downstream or parallel signaling pathway to that of Vmn2r58. Inhibition of mTOR by Rapamycin would result in reduced activity of Vmn2r58 due to disrupted signaling required for its function. | ||||||
Gö 6976 | 136194-77-9 | sc-221684 | 500 µg | $223.00 | 8 | |
Gö6976 is a protein kinase C (PKC) inhibitor. If Vmn2r58's function is dependent on PKC-mediated signaling, inhibition of PKC by Gö6976 would lead to functional inhibition of Vmn2r58. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $182.00 $693.00 | 88 | |
Y-27632 is a Rho-associated protein kinase (ROCK) inhibitor, and the ROCK pathway may intersect with signaling pathways involving Vmn2r58. Inhibiting ROCK by Y-27632 would impair downstream signaling required for Vmn2r58's function. | ||||||