Vmn2r29 Activators
Chemical activators of Vmn2r29 include a range of compounds that engage in various biochemical pathways to modulate the activity of this protein. Sodium fluoride, for instance, enhances the levels of cyclic AMP (cAMP) by activating adenylate cyclase. The increased cAMP can then stimulate protein kinases, which are capable of phosphorylating and hence activating G-protein coupled receptors (GPCRs) such as Vmn2r29. Similarly, cholera toxin exerts its effect by catalyzing the ADP-ribosylation of G proteins, perpetuating the activation of adenylate cyclase, and thereby elevating cAMP levels. The heightened cAMP activates protein kinases that may target GPCRs, including Vmn2r29, for activation.
Other compounds like forskolin and isoproterenol directly target the adenylate cyclase or beta-adrenergic receptors, respectively, to raise cAMP levels within the cell, leading to the activation of protein kinases that can phosphorylate Vmn2r29. GTPγS, on the other hand, acts by binding to G-proteins in a non-hydrolysable manner, which might result in sustained activation of associated GPCRs such as Vmn2r29. Aluminum fluoride stabilizes G-proteins in an active form, possibly influencing the activity of Vmn2r29. Additionally, MnCl2 and MgCl2 serve as essential cofactors for G-proteins, with manganese facilitating the active conformation and magnesium being crucial for GTP binding to G-proteins, processes that are fundamental for the activation of GPCRs like Vmn2r29. Histamine and angiotensin II achieve their effects through binding to their respective GPCRs, which can set off a cascade of intracellular signaling events, including kinase activation that may also lead to the phosphorylation and activation of Vmn2r29. Lastly, adenosine and pilocarpine, through their interactions with specific GPCRs, can activate downstream G-proteins and kinases, ultimately influencing the activation state of Vmn2r29.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Sodium Fluoride | 7681-49-4 | sc-24988A sc-24988 sc-24988B | 5 g 100 g 500 g | $39.00 $45.00 $98.00 | 26 | |
Sodium fluoride activates adenylate cyclase leading to an increase in cAMP levels, which can enhance the activity of protein kinases known to phosphorylate and hence activate G-protein coupled receptors (GPCRs) such as Vmn2r29. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin directly activates adenylate cyclase, resulting in increased cAMP production. The rise in cAMP can activate protein kinases, which subsequently can phosphorylate and activate GPCR proteins such as Vmn2r29. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $27.00 $37.00 | 5 | |
Isoproterenol is a non-selective beta-adrenergic agonist that can increase intracellular cAMP levels, potentially leading to the activation of protein kinases that phosphorylate and activate GPCRs in the same pathway as Vmn2r29. | ||||||
Guanosine 5′-O-(3-thiotriphosphate) tetralithium salt | 94825-44-2 | sc-202639 | 10 mg | $456.00 | ||
GTPγS is a non-hydrolysable analogue of GTP that can bind to and activate G-proteins, which in turn can activate G-protein-coupled receptors such as Vmn2r29. | ||||||
Aluminum Fluoride | 7784-18-1 | sc-291881 sc-291881A | 10 g 50 g | $66.00 $245.00 | ||
Aluminum fluoride acts as a phosphate analog and stabilizes the G-protein in its active form, which may lead to activation of downstream GPCRs like Vmn2r29. | ||||||
Manganese(II) chloride beads | 7773-01-5 | sc-252989 sc-252989A | 100 g 500 g | $19.00 $30.00 | ||
Manganese chloride (MnCl2) can act as a cofactor for G-proteins, potentially facilitating their active conformation and thereby leading to the activation of associated GPCRs such as Vmn2r29. | ||||||
Magnesium chloride | 7786-30-3 | sc-255260C sc-255260B sc-255260 sc-255260A | 10 g 25 g 100 g 500 g | $27.00 $34.00 $47.00 $123.00 | 2 | |
Magnesium chloride (MgCl2) is essential for G-protein activation, as magnesium ions are required for GTP binding to G-proteins, which could lead to the activation of GPCRs such as Vmn2r29. | ||||||
Histamine, free base | 51-45-6 | sc-204000 sc-204000A sc-204000B | 1 g 5 g 25 g | $92.00 $277.00 $969.00 | 7 | |
Histamine, through its action on its own GPCRs, can influence intracellular signaling pathways, leading to the activation of protein kinases that may cross-activate other GPCRs in the same signaling network as Vmn2r29. | ||||||
Adenosine | 58-61-7 | sc-291838 sc-291838A sc-291838B sc-291838C sc-291838D sc-291838E sc-291838F | 1 g 5 g 100 g 250 g 1 kg 5 kg 10 kg | $33.00 $47.00 $294.00 $561.00 $1020.00 $2550.00 $4590.00 | 1 | |
Adenosine interacts with its GPCRs to activate adenylate cyclase, increasing cAMP and activating protein kinases that could phosphorylate and activate other GPCRs in the same family as Vmn2r29. | ||||||
Pilocarpine | 92-13-7 | sc-479256 | 100 mg | $250.00 | 1 | |
Pilocarpine, a muscarinic acetylcholine receptor agonist, can activate G-proteins that may in turn activate other GPCRs in the same pathway, including Vmn2r29, through second messenger systems and subsequent protein kinase-mediated phosphorylation. | ||||||