Vmn1r91 Activators
Vomeronasal 1 receptor 91 (V1R91) activators encompass a variety of chemical compounds that enhance the receptor's functional activity through different mechanisms. Dihydrotestosterone and estradiol are hormones that can influence V1R91 by modulating the hormonal environment of the vomeronasal organ, potentially altering receptor sensitivity or expression. Sodium fluoride and forskolin, by acting as G-protein activators and adenylate cyclase activators respectively, can potentiate the signaling pathways V1R91 relies upon, thus enhancing its activity. Cholesterol contributes to the structural integrity of lipid rafts, which are crucial for the localization and optimal function of G-protein coupled receptors like V1R91. By sustaining these microdomains, cholesterol ensures that V1R91 is presented in a cellular context conducive to its activation.
Furthermore, pregnenolone sulfate and zinc sulfate modify the receptor environment and allosteric sites, respectively, which can potentiate V1R91 signaling. The presence of ATP, as a purinergic receptor ligand, influences the activity of nearby G-protein coupled receptors, potentially leading to enhanced V1R91 signaling through various mechanisms including heterologous desensitization. Piperine's enhancement of ligand bioavailability can increase V1R91 activation by ensuring higher local concentrations of activating molecules. Capsaicin and nicotine, though primarily agonists for other receptor types, can modulate G-protein coupled receptor function, which includes V1R91, by initiating signaling pathway cross-talk that results in enhanced V1R91 activity. Lastly,progesterone, by altering the hormonal milieu, might indirectly support the functional activity of V1R91 by affecting the responsiveness of the receptor within its native cellular environment.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
β-Estradiol | 50-28-2 | sc-204431 sc-204431A | 500 mg 5 g | $62.00 $178.00 | 8 | |
Estradiol is a form of estrogen that binds to estrogen receptors influencing gene expression. It can indirectly enhance V1R91 activity by affecting the hormonal milieu that modulates vomeronasal organ responsiveness. | ||||||
Sodium Fluoride | 7681-49-4 | sc-24988A sc-24988 sc-24988B | 5 g 100 g 500 g | $39.00 $45.00 $98.00 | 26 | |
Sodium fluoride acts as a G-protein activator, which can enhance the activity of G-protein coupled receptors like V1R91 by promoting G-protein signaling pathways. | ||||||
Cholesterol | 57-88-5 | sc-202539C sc-202539E sc-202539A sc-202539B sc-202539D sc-202539 | 5 g 5 kg 100 g 250 g 1 kg 25 g | $26.00 $2754.00 $126.00 $206.00 $572.00 $86.00 | 11 | |
Cholesterol is a component of cell membranes and is involved in the formation of lipid rafts, which can influence the localization and function of G-protein coupled receptors such as V1R91. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin activates adenylate cyclase to increase cAMP levels, which can enhance the signaling of G-protein coupled receptors like V1R91 by promoting receptor-mediated signal transduction. | ||||||
Pregnenolone sulfate sodium salt | 1852-38-6 | sc-301609 | 50 mg | $97.00 | 2 | |
Pregnenolone sulfate acts as a neurosteroid that can modulate G-protein coupled receptor function, potentially enhancing V1R91 signaling by modulating membrane receptor environments. | ||||||
Zinc | 7440-66-6 | sc-213177 | 100 g | $47.00 | ||
Zinc is known to be a positive allosteric modulator for some G-protein coupled receptors, and it may enhance V1R91 function by stabilizing receptor conformation and supporting receptor-ligand interactions. | ||||||
Adenosine 5′-Triphosphate, disodium salt | 987-65-5 | sc-202040 sc-202040A | 1 g 5 g | $38.00 $74.00 | 9 | |
ATP can serve as a ligand for purinergic receptors, which can modulate the activity of nearby G-protein coupled receptors like V1R91 through heterologous desensitization or by altering receptor microenvironments. | ||||||
Piperine | 94-62-2 | sc-205809 sc-205809A | 5 g 25 g | $36.00 $143.00 | 3 | |
Piperine is an alkaloid that can enhance the bioavailability of various compounds and may increase the functional activity of V1R91 by modulating the local concentration of its ligands or receptor modulators. | ||||||
Capsaicin | 404-86-4 | sc-3577 sc-3577C sc-3577D sc-3577A | 50 mg 250 mg 500 mg 1 g | $94.00 $173.00 $255.00 $423.00 | 26 | |
Capsaicin is a vanilloid receptor agonist that can influence nearby G-protein coupled receptors like V1R91 through cross-talk between signaling pathways, potentially enhancing V1R91 activity. | ||||||
Progesterone | 57-83-0 | sc-296138A sc-296138 sc-296138B | 1 g 5 g 50 g | $20.00 $51.00 $292.00 | 3 | |
Progesterone can modulate G-protein coupled receptors signaling by binding to its receptor, which might indirectly enhance V1R91 function by altering the hormonal environment and receptor responsiveness. | ||||||