Vmn1r12 Activators
Vmn1r12, also known as vomeronasal 1 receptor 12, plays a pivotal role in the olfactory system, specifically in vomeronasal receptor signaling. This receptor is involved in detecting chemical cues related to social and reproductive behaviors. The activation of Vmn1r12 is intricately regulated by various chemicals that directly or indirectly influence its function. Functionally, Vmn1r12 responds to specific chemical cues by initiating signal transduction cascades within the vomeronasal organ. The receptor is associated with the detection of pheromones and other chemosensory signals, contributing to social communication and reproductive behaviors in various species. The intricate interplay of chemicals, as outlined in the provided table, modulates cellular processes associated with Vmn1r12, ultimately leading to its up-regulation and enhanced activity within the vomeronasal receptor system.
Activation mechanisms involve direct activators, such as 8-Bromo-cAMP mimicking endogenous cAMP, and indirect activators, like Sodium Butyrate influencing histone acetylation. These chemicals modulate pathways related to olfactory signal transduction, chromatin accessibility, and ion homeostasis, contributing to the intricate regulation of Vmn1r12. Understanding these activation mechanisms provides insights into the molecular processes governing vomeronasal receptor signaling, shedding light on the complex interplay of chemicals that regulate Vmn1r12 function in the context of chemosensory communication.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic Acid acts as an indirect activator by binding to retinoic acid receptors (RARs), leading to the up-regulation of Vmn1r12. RARs modulate gene expression, specifically influencing pathways related to olfactory signal transduction. This activation occurs through the modulation of gene expression profiles that indirectly promote Vmn1r12 function in vomeronasal receptor signaling. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $31.00 $47.00 $84.00 $222.00 | 19 | |
Sodium Butyrate acts as a histone deacetylase inhibitor, promoting histone acetylation. This epigenetic modulation indirectly up-regulates Vmn1r12 by facilitating a permissive chromatin state. The increased acetylation enhances accessibility to the gene, positively influencing Vmn1r12 transcription. Sodium Butyrate's impact on histone modification contributes to the promotion of Vmn1r12 expression in a cellular context related to vomeronasal receptor function. | ||||||
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $91.00 $139.00 $374.00 | 36 | |
Dexamethasone, a glucocorticoid, modulates cellular pathways associated with Vmn1r12. By influencing glucocorticoid receptor signaling, it indirectly triggers processes leading to the up-regulation of Vmn1r12. The detailed mechanism involves interactions with intracellular receptors and subsequent gene expression alterations, contributing to the enhancement of Vmn1r12 activity within the context of vomeronasal receptor function. | ||||||
Nicotinic Acid | 59-67-6 | sc-205768 sc-205768A | 250 g 500 g | $62.00 $124.00 | 1 | |
Nicotinic Acid induces activation of G protein-coupled receptors, initiating downstream signaling pathways. This indirect activation contributes to the enhancement of Vmn1r12 function within the vomeronasal receptor system. The specific GPCR-mediated signaling events influenced by Nicotinic Acid play a crucial role in promoting Vmn1r12 activity, illustrating how this chemical modulates cellular processes to amplify the signal transduction pathways associated with vomeronasal receptor activation. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium Chloride modulates the Wnt/β-catenin signaling pathway, indirectly affecting Vmn1r12 activation. By inhibiting GSK-3β, Lithium Chloride stabilizes β-catenin, influencing downstream gene expression. This indirect activation pathway enhances Vmn1r12 function within the context of vomeronasal receptor signaling. The modulation of the Wnt pathway by Lithium Chloride provides an indirect means to promote Vmn1r12 expression and activity in cellular environments associated with vomeronasal receptor function. | ||||||
8-Bromo-cAMP | 76939-46-3 | sc-201564 sc-201564A | 10 mg 50 mg | $126.00 $328.00 | 30 | |
8-Bromo-cAMP, a cAMP analog, directly stimulates cAMP-dependent signaling pathways. Its activation of these pathways serves as a direct activator for Vmn1r12, enhancing its function within the vomeronasal receptor system. By mimicking the action of endogenous cAMP, 8-Bromo-cAMP directly promotes Vmn1r12 activity, amplifying the signal transduction cascade associated with vomeronasal receptor activation. The direct influence of 8-Bromo-cAMP on cAMP-dependent pathways directly contributes to the up-regulation of Vmn1r12 in relevant cellular contexts. | ||||||
Valproic Acid | 99-66-1 | sc-213144 | 10 g | $87.00 | 9 | |
Sodium Valproate, a histone deacetylase inhibitor, modulates histone acetylation patterns. This epigenetic alteration indirectly activates Vmn1r12 by creating a conducive chromatin environment for gene expression. Sodium Valproate's impact on histone modifications leads to the up-regulation of Vmn1r12, illustrating how epigenetic modulation influences vomeronasal receptor function by indirectly promoting the expression and activity of Vmn1r12 in relevant cellular contexts. | ||||||
Cobalt(II) chloride | 7646-79-9 | sc-252623 sc-252623A | 5 g 100 g | $64.00 $176.00 | 7 | |
Cobalt Chloride induces hypoxia-mimicking conditions, activating hypoxia-inducible factor 1-alpha (HIF-1α). This indirect activation pathway enhances Vmn1r12 function within the context of vomeronasal receptor signaling. The modulation of HIF-1α by Cobalt Chloride provides an indirect means to promote Vmn1r12 expression and activity in cellular environments associated with hypoxia-induced activation of vomeronasal receptor signaling pathways. Cobalt Chloride's impact on HIF-1α stabilization contributes to the up-regulation of Vmn1r12 in relevant cellular contexts. | ||||||
Valinomycin | 2001-95-8 | sc-200991 | 25 mg | $250.00 | 3 | |
Valinomycin, a potassium ionophore, modulates intracellular potassium levels. This indirect activation influences cellular processes associated with Vmn1r12 function within the vomeronasal receptor system. By altering potassium ion concentrations, Valinomycin indirectly up-regulates Vmn1r12, highlighting the impact of ion homeostasis on vomeronasal receptor signaling. The modulation of intracellular potassium levels by Valinomycin serves as an indirect means to promote Vmn1r12 expression and activity in cellular environments relevant to vomeronasal receptor function. | ||||||
Butyric acid | 107-92-6 | sc-214640 sc-214640A | 1 kg 10 kg | $64.00 $177.00 | ||
Butyric Acid acts as a short-chain fatty acid, influencing histone acetylation patterns. This epigenetic modulation indirectly activates Vmn1r12 by promoting a permissive chromatin state for gene expression. Butyric Acid's impact on histone modifications leads to the up-regulation of Vmn1r12, illustrating how epigenetic modulation influences vomeronasal receptor function by indirectly promoting the expression and activity of Vmn1r12 in relevant cellular contexts. | ||||||