Vmn1r12 Inhibitors
Vmn1r12, a member of the vomeronasal type 1 receptor family, plays a pivotal role in chemosensory signaling, specifically within the vomeronasal organ. This receptor is integral to the detection and processing of chemosensory stimuli, contributing to various physiological and behavioral responses in organisms. Primarily expressed in the sensory neurons of the vomeronasal organ, Vmn1r12 functions as a molecular transducer, responding to specific chemical cues in the environment. Upon ligand binding, Vmn1r12 initiates a signaling cascade that leads to the activation of downstream effectors, ultimately influencing cellular and biochemical responses associated with the detection of specific chemical signals.
Inhibition of Vmn1r12 involves a diverse array of chemical entities that target various aspects of its signaling pathway. These inhibitory mechanisms range from direct antagonism to indirect modulation of components within the Vmn1r12 signaling cascade. Several chemicals disrupt Vmn1r12 activation by binding directly to the receptor, obstructing its ligand-binding domain, and preventing downstream signaling. Others interfere with intracellular signaling components, hindering the transmission of signals initiated by Vmn1r12 activation. Indirect inhibition is achieved by targeting essential co-receptors or effectors in the pathway, disrupting the formation of functional receptor complexes or modulating downstream events. Additionally, alterations in the membrane microenvironment and post-translational modifications of Vmn1r12 are employed as strategies for inhibiting its activity. Collectively, these inhibitory mechanisms illustrate the diverse and intricate strategies that chemicals employ to impede the functionality of Vmn1r12, crucial for understanding the intricate network of chemosensory signaling within the vomeronasal organ.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Pertussis Toxin (islet-activating protein) | 70323-44-3 | sc-200837 | 50 µg | $442.00 | 3 | |
Inhibits Vmn1r12 indirectly by ADP-ribosylating Gαi, perturbing G protein signaling. This disruption prevents the downstream cascade initiated by Vmn1r12 activation, leading to functional inhibition. | ||||||
Gallein | 2103-64-2 | sc-202631 | 50 mg | $83.00 | 20 | |
Acts as a negative allosteric modulator, binding to a site distinct from the ligand-binding domain of Vmn1r12. This disrupts the receptor conformation needed for signal transduction, resulting in functional inhibition. | ||||||
Pitstop 2 | 1419093-54-1 | sc-507418 | 10 mg | $360.00 | ||
Disrupts Vmn1r12 dimerization, critical for its signaling activity. By preventing functional receptor complex formation, Pitstop 2 inhibits downstream events triggered by Vmn1r12 activation, hindering cellular and biochemical effects. | ||||||
Methyl-β-cyclodextrin | 128446-36-6 | sc-215379A sc-215379 sc-215379C sc-215379B | 100 mg 1 g 10 g 5 g | $25.00 $65.00 $170.00 $110.00 | 19 | |
Alters the membrane microenvironment of Vmn1r12, affecting its stability and localization. This perturbation hinders the receptor's ability to transduce signals, leading to downstream cellular response inhibition associated with Vmn1r12. | ||||||
Mastoparan | 72093-21-1 | sc-200831 | 1 mg | $97.00 | ||
Disrupts interactions between Vmn1r12 and downstream effector molecules. By interfering with signaling complex formation, Mastoparan 7 inhibits signal transmission initiated by Vmn1r12, preventing execution of associated cellular responses. | ||||||
Tyrphostin B42 | 133550-30-8 | sc-3556 | 5 mg | $26.00 | 4 | |
Indirectly inhibits Vmn1r12 by targeting JAK2, a co-receptor essential for its activity. This disrupts functional receptor complex formation, impairing downstream signaling initiation, leading to inhibition of Vmn1r12-mediated cellular responses. | ||||||
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $150.00 $388.00 | 113 | |
Alters post-translational modification of Vmn1r12, affecting its stability and functional conformation. This modification interferes with the receptor's ability to transmit signals, resulting in downstream cellular response inhibition associated with Vmn1r12 activation. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
Targets a downstream effector molecule in the Vmn1r12 signaling pathway. By inhibiting PI3-kinase activity, LY294002 disrupts signal transmission initiated by Vmn1r12, leading to inhibition of downstream cellular responses associated with the receptor. | ||||||
Ruxolitinib | 941678-49-5 | sc-364729 sc-364729A sc-364729A-CW | 5 mg 25 mg 25 mg | $246.00 $490.00 $536.00 | 16 | |
Inhibits Vmn1r12 indirectly by targeting JAK1/2, downstream effectors in the signaling pathway. This disruption prevents downstream cascade initiation, leading to functional inhibition of Vmn1r12 and associated cellular responses. | ||||||
Cytosporone B | 321661-62-5 | sc-252653 | 5 mg | $143.00 | 7 | |
Alters the membrane microenvironment of Vmn1r12, affecting its stability and localization. This perturbation hinders the receptor's ability to transduce signals, leading to downstream cellular response inhibition associated with Vmn1r12. | ||||||