Mastoparan CAS: 72093-21-1
MF: C70H131N19O15
MW: 1478.93
A G-protein activator.

Mastoparan (CAS 72093-21-1)

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Solicitud: A G-protein activator
Número de CAS: 72093-21-1
Peso Molecular: 1478.93
Fórmula Molecular: C70H131N19O15
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Mastoparan (Vespula lewisii) has been shown to cause an increase in the production of Arachidonic Acid (sc-200770) catalyzed by PLA2 from porcine pancreas and bee venom. This compound also displays toxicity by regulating G proteins via mimicking of G-protein-coupled receptors. Additionally, Mastoparan has been reported as a stimulator of insulin release by pancreatic islets, which acts through GTP-binding proteins and PLA2. In other experiments, this agent has demonstrated the ability to cause exocytosis of rat peritoneal mast cells and also stimulate the accumulation of inositol phosphates in hepatocytes. Additionally, Mastoparan has been noted to act as a mitogen in Swiss 3T3 cells and stimulate pertussis toxin-sensitive Arachidonate release without phosphoinositide breakdown. Mastoparan (Vespula lewisii) is an inhibitor of CaM. Mastoparan (Vespula lewisii) is an activator of Heterotrimeric G Protein and PLA2.


References

1. Argiolas, A. and Pisano, J.J. 1983. J. Biol. Chem. 258: 13697-13702. PMID: 6643447
2. Higashijima, T., et al. 1988. J. Biol. Chem. 263: 6491-6494. PMID: 3129426
3. Yokokawa, N., et al. 1989. Biochem. Biophys. Res. Commun. 158: 712-716. PMID: 2493246
4. Mousli, M., et al. 1989. J. Pharmacol. Exp. Ther. 250: 329-335. PMID: 2473189
5. Higashijima, T., et al. 1990. J. Biol. Chem. 265: 14176-14186. PMID: 2117607
6. Gil, J., et al. 1991. J. Cell Biol. 113: 943-950. PMID: 1709171

Estado de Materia :
Solid
Forma Derivada :
Synthetic. Originally isolated from wasp venom (Vespula lewisii)
Solubilidad :
Soluble in water (2.6 mg/ml), and 100% ethanol.
ALMACENAMIENTO :
Store at -20° C
Indice de Refracción :
n20D 1.53
IC50 :
Na+,K+-ATPase: IC50 = 7.5 µM
Para Uso Exclusivo en Investigación. No está diseñado para uso en diagnosis o terapia.
WGK Alemania :
3
PubChem CID :
5464497
Número MDL :
MFCD00076865
Registro Beilstein :
5491949
SMILES :
CC[[email protected]](C)[[email protected]@H](C(=O)N[[email protected]@H](CC(=O)N)C(=O)N[[email protected]@H](CC(C)C)C(=O)N[[email protected]@H](CCCCN)C(=O)N[[email protected]@H](C)C(=O)N[[email protected]@H](CC(C)C)C(=O)N[[email protected]@H](C)C(=O)N[[email protected]@H](C)C(=O)N[[email protected]@H](CC(C)C)C(=O)N[[email protected]@H](C)C(=O)N[[email protected]@H](CCCCN)C(=O)N[[email protected]@H](CCCCN)C(=O)N[[email protected]@H](C(C)CC)C(=O)N[[email protected]@H](CC(C)C)C(=O)N)N

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