VILIP-2 Activators
VILIP-2 activators encompass a diverse group of compounds primarily associated with the modulation of calcium signaling in neurons. These compounds can indirectly influence the activation state and function of VILIP-2, which as a neuronal calcium sensor protein, responds to the alterations in intracellular calcium concentrations. Agents like nifedipine, verapamil, and nimodipine function by inhibiting L-type calcium channels, which may lead to changes in the calcium-dependent processes that VILIP-2 is involved in.
By modulating calcium dynamics within neurons, these compounds can create a cellular environment that necessitates the compensatory activation of calcium-binding proteins such as VILIP-2 to help restore calcium homeostasis. Furthermore, compounds like caffeine and forskolin, which operate through the cAMP/PKA signaling pathway, can also indirectly impact VILIP-2 activity by affecting the phosphorylation states of proteins involved in calcium channel regulation.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Caffeine | 58-08-2 | sc-202514 sc-202514A sc-202514B sc-202514C sc-202514D | 50 g 100 g 250 g 1 kg 5 kg | $33.00 $67.00 $97.00 $192.00 $775.00 | 13 | |
A phosphodiesterase inhibitor that can increase cyclic AMP (cAMP) levels and activate protein kinase A (PKA), which can phosphorylate substrates that affect calcium channel function, potentially influencing the activity of VILIP-2 through altered calcium dynamics. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
An activator of adenylyl cyclase which increases cAMP levels, leading to PKA activation. This cascade can modulate calcium channels and intracellular calcium levels, thereby potentially affecting VILIP-2 activity. | ||||||
Nitrendipine | 39562-70-4 | sc-201466 sc-201466A sc-201466B | 50 mg 100 mg 500 mg | $109.00 $160.00 $458.00 | 6 | |
A calcium channel blocker that can alter L-type calcium channel function and thus modify neuronal calcium signaling, potentially influencing the activity of VILIP-2. | ||||||
Ciprofloxacin | 85721-33-1 | sc-217900 | 1 g | $43.00 | 8 | |
A peptide that inhibits N-type voltage-dependent calcium channels, which could modulate neuronal calcium influx and indirectly influence VILIP-2 activation. | ||||||
ω-Agatoxin IVA | 145017-83-0 | sc-302015 | 100 µg | $463.00 | ||
A peptide inhibitor of P/Q-type calcium channels that could alter neuronal calcium signaling and affect VILIP-2 activity. | ||||||
Amlodipine | 88150-42-9 | sc-200195 sc-200195A | 100 mg 1 g | $74.00 $166.00 | 2 | |
A long-acting calcium channel blocker with selectivity for L-type calcium channels, which by affecting calcium influx in neurons, may indirectly modulate VILIP-2 activity. | ||||||
Gabapentin | 60142-96-3 | sc-201481 sc-201481A sc-201481B | 20 mg 100 mg 1 g | $53.00 $94.00 $135.00 | 7 | |
Although not a direct modulator of calcium channels, it binds to the auxiliary subunit of voltage-gated calcium channels and can modulate neuronal excitability, potentially affecting VILIP-2 activity by altering calcium dynamics. | ||||||