VILIP-2 Antibody (11B10): sc-135603

VILIP-2 Antibody (11B10) is a mouse monoclonal IgG2a kappa light chain antibody that detects VILIP-2 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-VILIP-2 antibody (11B10) is available as a non-conjugated format. VILIP-2, also known as hippocalcin-like 4 (HPCAL4), plays a crucial role in calcium signaling within neurons, particularly in the neocortex and hippocampus, where VILIP-2 is predominantly expressed. VILIP-2 is part of the visinin-like family of neuronal calcium sensor proteins, which are essential for various cellular processes, including synaptic transmission and plasticity. VILIP-2 contains four EF-hand domains that facilitate calcium ion binding, and VILIP-2 interacts with two or three calcium ions, which is vital for modulating rhodopsin phosphorylation, a key protein in the phototransduction pathway. The gene encoding VILIP-2, located on chromosome 1p34.2, features multiple polyadenylation sites, indicating complex regulation of expression. VILIP-2 (11B10) antibody is an invaluable tool for researchers studying calcium-dependent signaling pathways and their implications in neuronal function and disease.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

VILIP-2 Antibody (11B10) References:

1. Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.  |  Wiemann, S., et al. 2001. Genome Res. 11: 422-35. PMID: 11230166
2. Modulation of CaV2.1 channels by the neuronal calcium-binding protein visinin-like protein-2.  |  Lautermilch, NJ., et al. 2005. J Neurosci. 25: 7062-70. PMID: 16049183
3. Differential regulation of CaV2.1 channels by calcium-binding protein 1 and visinin-like protein-2 requires N-terminal myristoylation.  |  Few, AP., et al. 2005. J Neurosci. 25: 7071-80. PMID: 16049184
4. Isolation of two human cDNAs, HLP3 and HLP4, homologous to the neuron-specific calcium-binding protein genes.  |  Kobayashi, M., et al. 1998. DNA Seq. 9: 171-6. PMID: 10520747

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-VILIP-2 Antibody (11B10) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-VILIP-2 Antibody (11B10) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

VILIP-2 Antibody (11B10) Specifications

Alternate Product Name: VILIP-2

Product Clone Name: 11B10

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 1-192

Epitope Target: VILIP-2

Epitope Species: human

Product Reactivity/Detection: VILIP-2

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, ELISA

Vialing Information: Each vial contains 100 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for VILIP-2 Antibody (11B10): N/A