V1RB Activators
V1RB Activators are a diverse group of chemical compounds that enhance the functional activity of V1RB through distinct yet convergent signaling pathways. Forskolin, Isoproterenol, PGE2, Histamine, and Caffeine all elevate intracellular cAMP levels but through different mechanisms, such as direct activation of adenylyl cyclase or inhibition of phosphodiesterases. The increase in cAMP levels activates PKA, which is capable of phosphorylating proteins including V1RB, thereby enhancing its activity as part of the sensory signaling. Nicotine and Zinc contribute to this enhancement by modulating the receptor signaling and stabilization. L-Arginine and Sildenafil, through their roles as precursors or inhibitors related to the cGMP pathway, indirectly influence the cAMP levels, which could augment V1RBactivity through complex intracellular cross-talk mechanisms.
The action of chemicals like 8-Br-cAMP and Rolipram bypasses upstream activators and directly increases PKA activity or cAMP levels, respectively, leading to an enhanced phosphorylation state and activity of V1RB. Capsaicin, on the other hand, utilizes the calcium signaling pathway to activate CaMK, which may subsequently interact with cAMP-dependent pathways, potentially resulting in the phosphorylation and activation of V1RB. Collectively, these V1RB activators work through various biochemical routes to ensure the enhancement of V1RB signaling by targeting different aspects of the receptor's activation and regulatory mechanisms. Each activator, while distinct in its initial target and mechanism, ultimately converges on the modulation of intracellular signaling cascades that facilitate the increased activity of V1RB without altering its expression levels, ensuring a more potent and regulated sensory response.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin is a diterpene derived from the plant Coleus forskohlii. It directly stimulates adenylyl cyclase, increasing intracellular cAMP levels. Elevated cAMP activates PKA (Protein Kinase A), which can phosphorylate various proteins and receptors, including V1RB, leading to its enhanced functional activity as a sensory receptor. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $28.00 $38.00 | 5 | |
Isoproterenol is a synthetic catecholamine and beta-adrenergic agonist. It activates beta-adrenergic receptors, leading to Gs protein activation and subsequent stimulation of adenylyl cyclase. The resulting rise in cAMP levels indirectly enhances V1RB activity by promoting G protein-coupled receptor signaling, which V1RB is a part of. | ||||||
PGE2 | 363-24-6 | sc-201225 sc-201225C sc-201225A sc-201225B | 1 mg 5 mg 10 mg 50 mg | $57.00 $159.00 $275.00 $678.00 | 37 | |
Prostaglandin E2 is a lipid compound that activates G protein-coupled receptors, leading to the activation of adenylate cyclase and increased cAMP production. This signaling cascade can contribute to the activation of V1RB by facilitating the G protein coupling and signaling processes that V1RB is involved in. | ||||||
Histamine, free base | 51-45-6 | sc-204000 sc-204000A sc-204000B | 1 g 5 g 25 g | $94.00 $283.00 $988.00 | 7 | |
Histamine, through its action on H2 receptors, can increase cAMP levels by activating adenylyl cyclase. This elevation in cAMP may enhance the activity of V1RB, which is modulated by cAMP-dependent pathways in sensory neurons. | ||||||
L-Arginine | 74-79-3 | sc-391657B sc-391657 sc-391657A sc-391657C sc-391657D | 5 g 25 g 100 g 500 g 1 kg | $20.00 $31.00 $61.00 $219.00 $352.00 | 2 | |
L-Arginine is a precursor to nitric oxide (NO), which activates guanylyl cyclase, leading to increased cGMP levels. cGMP can modulate cAMP levels through cross-talk mechanisms, potentially enhancing the functional activity of V1RB. | ||||||
8-Bromoadenosine 3′,5′-cyclic monophosphate | 23583-48-4 | sc-217493B sc-217493 sc-217493A sc-217493C sc-217493D | 25 mg 50 mg 100 mg 250 mg 500 mg | $108.00 $169.00 $295.00 $561.00 $835.00 | 2 | |
8-Bromoadenosine 3’,5’-cyclic monophosphate is a cell-permeable cAMP analog that directly stimulates PKA. Activated PKA can phosphorylate V1RB or associated regulatory proteins, thereby enhancing V1RB signaling. | ||||||
Zinc | 7440-66-6 | sc-213177 | 100 g | $48.00 | ||
Zinc can act as a modulator of G protein-coupled receptors and their signaling pathways. It may enhance V1RB activity by stabilizing the receptor conformation that prefers active signaling states. | ||||||
Caffeine | 58-08-2 | sc-202514 sc-202514A sc-202514B sc-202514C sc-202514D | 50 g 100 g 250 g 1 kg 5 kg | $33.00 $67.00 $97.00 $192.00 $775.00 | 13 | |
Caffeine inhibits phosphodiesterases, leading to increased cAMP levels by preventing its breakdown. Elevated cAMP can enhance V1RB signaling by activating PKA, which in turn could phosphorylate and activate V1RB directly or modulate its signaling pathway. | ||||||
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $77.00 $216.00 | 18 | |
Rolipram is a selective inhibitor of phosphodiesterase 4 (PDE4), which leads to an increase in cAMP levels by preventing its degradation. This increase can indirectly enhance V1RB activity through cAMP-dependent signaling pathways. | ||||||
Capsaicin | 404-86-4 | sc-3577 sc-3577C sc-3577D sc-3577A | 50 mg 250 mg 500 mg 1 g | $96.00 $160.00 $240.00 $405.00 | 26 | |
Capsaicin binds to the TRPV1 receptor, leading to an influx of calcium ions. This increased intracellular calcium can activate calmodulin-dependent kinase (CaMK), which may cross-talk with cAMP pathways, indirectly enhancing V1RB activity through phosphorylation events. | ||||||