USMG5 Inhibitors
USMG5 inhibitors are a class of chemical compounds that target the function of USMG5, a minor subunit of the mitochondrial membrane ATP synthase. This protein plays a role in the dimerization of the ATP synthase complex, a critical step for ATP synthesis in mitochondria. ATP synthesis is essential for a range of cellular activities, and the ATP synthase complex itself consists of two main structural domains, F1 and F0. USMG5 is particularly involved in the latter. The inhibitors in this class act by various mechanisms, including the disruption of the proton gradient essential for ATP synthesis, the direct inhibition of ATP synthase components, or the uncoupling of oxidative phosphorylation from ATP synthesis. Some of these compounds, like Oligomycin A, focus on inhibiting the ATP synthase activity directly, thereby affecting USMG5's role in the dimerization process, which is essential for ATP synthesis.
Moreover, some inhibitors, like FCCP and 2,4-DNP, uncouple oxidative phosphorylation, affecting the proton gradient across the mitochondrial membrane. Others, such as Azide and Rotenone, target the electron transport chain, which is upstream of ATP synthase activity but crucial for maintaining the proton gradient. Yet another set of compounds, like DCCD, bind covalently to components of the ATP synthase, affecting the structural integrity of the complex where USMG5 exerts its function. By targeting different stages and components of the ATP synthesis pathway or the electron transport chain, these inhibitors can offer multiple avenues for understanding the role and function of USMG5 in cellular metabolism.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Oligomycin A | 579-13-5 | sc-201551 sc-201551A sc-201551B sc-201551C sc-201551D | 5 mg 25 mg 100 mg 500 mg 1 g | $179.00 $612.00 $1203.00 $5202.00 $9364.00 | 26 | |
Oligomycin A is known to inhibit ATP synthase activity. It could potentially hinder the functionality of USMG5 by blocking the F0 domain, thereby affecting the dimerization process essential for ATP synthesis. | ||||||
FCCP | 370-86-5 | sc-203578 sc-203578A | 10 mg 50 mg | $94.00 $355.00 | 46 | |
FCCP uncouples oxidative phosphorylation from ATP synthesis. By dissipating the proton gradient, it could affect the role of USMG5 in proton translocation, thereby affecting ATP synthesis. | ||||||
Sodium azide | 26628-22-8 | sc-208393 sc-208393B sc-208393C sc-208393D sc-208393A | 25 g 250 g 1 kg 2.5 kg 100 g | $43.00 $155.00 $393.00 $862.00 $90.00 | 8 | |
Sodium azide is an inhibitor of cytochrome oxidase and could affect ATP synthase indirectly. Its presence could disrupt the proton gradient essential for the role of USMG5 in ATP synthesis. | ||||||
DCC | 538-75-0 | sc-239713 sc-239713A | 25 g 100 g | $72.00 $208.00 | 3 | |
DCC is an ATP synthase inhibitor that covalently binds to subunits of the F0 domain. It could potentially inhibit USMG5 by affecting the integrity of the ATP synthase complex. | ||||||
Rotenone | 83-79-4 | sc-203242 sc-203242A | 1 g 5 g | $89.00 $259.00 | 41 | |
Rotenone inhibits the electron transport chain at Complex I. The inhibition could reduce the proton gradient required for ATP synthesis, thereby affecting the function of USMG5. | ||||||
Antimycin A | 1397-94-0 | sc-202467 sc-202467A sc-202467B sc-202467C | 5 mg 10 mg 1 g 3 g | $55.00 $63.00 $1675.00 $4692.00 | 51 | |
Antimycin A inhibits Mitochondrial Complex III of the electron transport chain. The resulting disruption in proton gradient could impact the functional role of USMG5 in ATP synthesis. | ||||||
2,4-Dinitrophenol, wetted | 51-28-5 | sc-238345 | 250 mg | $59.00 | 2 | |
2,4-Dinitrophenol, wetted is a protonophore that uncouples oxidative phosphorylation. It could disturb the proton gradient across the membrane, affecting the role of USMG5 in ATP synthesis. | ||||||
Iodoacetic acid | 64-69-7 | sc-215183 sc-215183A | 10 g 25 g | $57.00 $99.00 | ||
Iodoacetic acid inhibits the glycolytic enzyme glyceraldehyde-3-phosphate dehydrogenase, potentially affecting ATP levels and indirectly influencing the function of USMG5 in ATP synthesis. | ||||||
2-Thenoyltrifluoroacetone | 326-91-0 | sc-251801 | 5 g | $37.00 | 1 | |
2-Thenoyltrifluoroacetone is an inhibitor of Mitochondrial Complex II and could disrupt the electron transport chain, thereby affecting the proton gradient and potentially inhibiting the function of USMG5 in ATP synthesis. | ||||||