USHBP1 Inhibitors
Chemical inhibitors of USHBP1 can impact the protein's functional capacity through diverse molecular interactions that impede various signaling pathways essential for its activity. Wortmannin and LY294002, as inhibitors of phosphoinositide 3-kinases (PI3K), can directly thwart the PI3K/Akt pathway, leading to a decrease in downstream signaling activities that are critical for the proper functioning of USHBP1. Similarly, the broad-spectrum kinase inhibitor staurosporine can disrupt multiple signaling pathways by inhibiting a wide range of kinases, which may interfere with the essential pathways on which USHBP1 relies. Moreover, U0126 and PD98059 specifically target MEK, a key component of the MAPK/ERK pathway. By impeding this pathway, the inhibitors can attenuate the phosphorylation events necessary for the proper functioning of USHBP1.
Further targeting the cellular signaling networks, SP600125 inhibits c-Jun N-terminal kinase (JNK), consequently altering the stress response mechanisms within the cell that can influence the role of USHBP1. SB203580 targets p38 MAP kinase, another stress-activated protein kinase, which when inhibited, can lead to reduced phosphorylation of substrates that USHBP1 may act upon. NF449 disrupts signal transduction by inhibiting G-protein coupled P2X1 receptors, potentially affecting the cellular processes involving USHBP1. Inhibition of protein kinase C (PKC) by Bisindolylmaleimide I and Gö6976 can also lead to the suppression of USHBP1 function, as PKC is known to regulate a variety of cellular functions. Lastly, lestaurtinib and dasatinib, both tyrosine kinase inhibitors, impede the activity of receptor tyrosine kinases and Src family kinases, respectively.
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Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin is a potent inhibitor of phosphoinositide 3-kinases (PI3K), which are involved in intracellular signaling pathways. Inhibition of PI3K can lead to decreased activity of downstream effectors that may be crucial for USHBP1 function, such as protein trafficking or cytoskeletal organization, thereby inhibiting USHBP1. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is another PI3K inhibitor that can prevent the phosphorylation and activation of proteins within the PI3K/Akt pathway, which is important for many cellular processes including those in which USHBP1 may be involved; this inhibition can reduce the functional activity of USHBP1. | ||||||
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $150.00 $388.00 | 113 | |
Staurosporine is a potent, non-selective inhibitor of protein kinases. By broadly inhibiting kinase activity, it can disrupt signaling pathways that USHBP1 relies on for its function, resulting in the inhibition of USHBP1's role in the cell. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
U0126 is an inhibitor of mitogen-activated protein kinase kinase (MEK), which is part of the MAPK/ERK pathway. This pathway can regulate processes that are potentially related to USHBP1 function, and inhibiting it can lead to reduced activity of USHBP1. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 is an inhibitor of c-Jun N-terminal kinase (JNK), which is implicated in cellular stress response pathways. Inhibition of JNK can alter the cellular environment in a way that inhibits the functional activity of USHBP1. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB203580 is a specific inhibitor of p38 MAP kinase, which is involved in inflammatory responses and stress signaling. Inhibiting p38 MAP kinase can prevent the phosphorylation of substrates necessary for USHBP1 function, leading to its inhibition. | ||||||
NF449 | 627034-85-9 | sc-478179 sc-478179A sc-478179B | 10 mg 25 mg 100 mg | $199.00 $460.00 $1479.00 | 1 | |
NF449 is a potent and selective inhibitor of G-protein coupled P2X1 receptors. By inhibiting these receptors, it can disrupt signal transduction pathways that might control cellular processes in which USHBP1 is involved, leading to functional inhibition of USHBP1. | ||||||
Bisindolylmaleimide I (GF 109203X) | 133052-90-1 | sc-24003A sc-24003 | 1 mg 5 mg | $103.00 $237.00 | 36 | |
Bisindolylmaleimide I is a specific inhibitor of protein kinase C (PKC), which is involved in a multitude of cellular processes, including those that could involve USHBP1. Inhibition of PKC can thus inhibit the functional activity of USHBP1. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD98059 is an inhibitor of MEK, which, similar to U0126, prevents the activation of the MAPK/ERK pathway. By inhibiting this pathway, PD98059 can lead to a reduction in USHBP1 activity as this pathway may be required for USHBP1's function. | ||||||
Lestaurtinib | 111358-88-4 | sc-218657 sc-218657A sc-218657B | 1 mg 5 mg 10 mg | $270.00 $320.00 $600.00 | 3 | |
Lestaurtinib is a tyrosine kinase inhibitor that can inhibit various receptor tyrosine kinases, which could be upstream of signaling pathways involving USHBP1. By inhibiting these kinases, lestaurtinib can reduce the functional activity of USHBP1. | ||||||