Uroguanylin Activators
Uroguanylin Activators constitute a diverse group of chemical compounds that indirectly facilitate the functional enhancement of Uroguanylin, a critical protein in regulating intestinal fluid and electrolyte balance. Sodium butyrate, a short-chain fatty acid, plays a pivotal role in this process by modulating GPCR signaling, leading to increased intracellular cGMP levels, a key second messenger in Uroguanylin signaling. Similarly, Forskolin's ability to elevate cAMP levels indirectly augments Uroguanylin's function, as cAMP activates PKA, influencing substrates involved in Uroguanylin signaling. Acetylcholine and (S)-(-)-Nicotine also contribute to this enhancement through their respective receptor-mediated pathways, leading to increased Uroguanylin secretion in intestinal epithelial cells. Curcumin and Caffeine, through their inhibition of PDEs, elevate cGMP levels, synergistically enhancing Uroguanylin's activity in managing intestinal ion transport. Capsaicin, by activating TRPV1 receptors, influences Uroguanylin secretion, further potentiating its role in intestinal dynamics. Bile acids, particularly Chenodeoxycholic Acid, Sodium Salt, boost Uroguanylin activity by stimulating its secretion, essential for maintaining gut homeostasis.
In addition to these mechanisms, other compounds like Linaclotide, Ginkgolide B, Resveratrol, and (-)-Epigallocatechin Gallate contribute to the functional enhancement of Uroguanylin. Linaclotide, a guanylate cyclase-C agonist, mimics Uroguanylin's effects, thereby indirectly boosting its activity by increasing cGMP in intestinal cells. Ginkgolide B, by modulating gastrointestinal dynamics, potentially leads to enhanced Uroguanylin secretion. Similarly, Resveratrol, through its effect on sirtuin activity, and (-)-Epigallocatechin Gallate, with its influence on intestinal cell signaling, can lead to an increase in Uroguanylin secretion. This diverse array of chemicals, each interacting with specific pathways or receptors, converges to enhance the activity of Uroguanylin in the gut, underscoring its critical role in maintaining fluid and electrolyte balance in the intestinal environment.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $31.00 $47.00 $84.00 $222.00 | 19 | |
Sodium Butyrate, a short-chain fatty acid, enhances Uroguanylin activity by modulating G protein-coupled receptor (GPCR) signaling. This compound increases intracellular cyclic GMP (cGMP) levels, which is a crucial second messenger in Uroguanylin signaling, leading to enhanced protein activation. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin, by elevating intracellular cAMP levels, indirectly enhances Uroguanylin function. The increase in cAMP activates PKA, which can phosphorylate substrates involved in Uroguanylin signaling, thus enhancing its activity in intestinal fluid regulation. | ||||||
Chenodeoxycholic Acid, Sodium Salt | 2646-38-0 | sc-280637 sc-280637A sc-280637B sc-280637C | 5 g 25 g 100 g 250 g | $67.00 $151.00 $426.00 $988.00 | 2 | |
Bile acids, particularly Chenodeoxycholic Acid, Sodium Salt, indirectly activate Uroguanylin by stimulating its secretion in the gut. This enhanced secretion is crucial for Uroguanylin's role in regulating intestinal fluid and electrolyte homeostasis. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin indirectly enhances Uroguanylin signaling by inhibiting phosphodiesterases (PDEs). This inhibition leads to increased cGMP levels, a critical second messenger in Uroguanylin's signaling pathway, thereby boosting its activity. | ||||||
Caffeine | 58-08-2 | sc-202514 sc-202514A sc-202514B sc-202514C sc-202514D | 50 g 100 g 250 g 1 kg 5 kg | $33.00 $67.00 $97.00 $192.00 $775.00 | 13 | |
Caffeine, a known phosphodiesterase inhibitor, indirectly boosts Uroguanylin activity by increasing intracellular cGMP levels. This action augments Uroguanylin's role in the regulation of intestinal ion transport and fluid balance. | ||||||
Capsaicin | 404-86-4 | sc-3577 sc-3577C sc-3577D sc-3577A | 50 mg 250 mg 500 mg 1 g | $96.00 $160.00 $240.00 $405.00 | 26 | |
Capsaicin activates TRPV1 receptors, which can lead to increased secretion of Uroguanylin in the gastrointestinal tract. This increased Uroguanylin level enhances its regulatory role in intestinal fluid dynamics and electrolyte balance. | ||||||
Ginkgolide B | 15291-77-7 | sc-201037B sc-201037 sc-201037C sc-201037A | 5 mg 10 mg 25 mg 50 mg | $46.00 $64.00 $114.00 $201.00 | 8 | |
Ginkgolide B, an inhibitor of platelet-activating factor, can indirectly enhance Uroguanylin activity by modulating gastrointestinal tract dynamics, potentially leading to increased Uroguanylin secretion and its functional activity. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol, by modulating sirtuin activity, can indirectly influence Uroguanylin signaling pathways. This modulation can enhance Uroguanylin's role in the gut, particularly in fluid and electrolyte balance. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
(-)-Epigallocatechin Gallate, primarily known for its antioxidant properties, can indirectly enhance Uroguanylin activity by influencing intestinal cell signaling pathways, possibly leading to increased Uroguanylin secretion and enhanced activity in intestinal homeostasis. | ||||||