UNC93A Inhibitors
Chemical inhibitors of UNC93A disrupt its role in the endosomal system, primarily by targeting processes essential for the trafficking and sorting of toll-like receptors. Bafilomycin A1 and Concanamycin A inhibit the vacuolar-type H+ ATPase (V-ATPase). This enzyme is critical for the acidification of endosomes, a process that is necessary for the proper function of UNC93A. By preventing this acidification, these inhibitors compromise the environment required for UNC93A to facilitate the correct localization of toll-like receptors. Similarly, Monensin, by acting as an ionophore, disrupts endosomal ion gradients, which also affects the pH and ion homeostasis critical for UNC93A's role in toll-like receptor sorting. Filipin III works differently by disrupting lipid rafts through cholesterol binding, which can impair the localization of toll-like receptors within endosomes, a process that UNC93A assists in orchestrating.
Dynasore and Dyngo-4a, both dynamin inhibitors, impede the scission of newly formed endocytic vesicles from the plasma membrane, which is essential for endocytosis. MiTMAB also targets dynamin but by inhibiting its GTPase activity, crucial for vesicle scission during endocytosis. These disruptions lead to an overall inhibition in the endosomal pathway, thereby affecting UNC93A functionality due to the impaired delivery of toll-like receptors to endosomes. Furthermore, Pitstop 2 and Chlorpromazine block clathrin-mediated endocytosis, which is another pathway that UNC93A relies on for sorting toll-like receptors. By impeding the formation of clathrin-coated vesicles, these inhibitors disrupt a critical step in endosomal trafficking. Additionally, Genistein and Tyrphostin AG 1478, as tyrosine kinase inhibitors, can obstruct the phosphorylation of proteins involved in endocytic trafficking, which is a key regulatory step for maintaining the endosomal sorting machinery that UNC93A is a part of. Each of these chemical inhibitors, by targeting different aspects of the endosomal pathway and vesicle trafficking, can directly or indirectly lead to the functional inhibition of UNC93A.
SEE ALSO...
Items 1 to 10 of 11 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Bafilomycin A1 | 88899-55-2 | sc-201550 sc-201550A sc-201550B sc-201550C | 100 µg 1 mg 5 mg 10 mg | $96.00 $250.00 $750.00 $1428.00 | 280 | |
Bafilomycin A1 inhibits V-ATPase, which is essential for acidification of endosomes. The function of UNC93A necessitates endosomal acidification for proper trafficking of toll-like receptors. By inhibiting V-ATPase, Bafilomycin A1 thereby inhibits the functional activity of UNC93A. | ||||||
Concanamycin A | 80890-47-7 | sc-202111 sc-202111A sc-202111B sc-202111C | 50 µg 200 µg 1 mg 5 mg | $65.00 $162.00 $650.00 $2550.00 | 109 | |
Concanamycin A, like Bafilomycin A1, is a V-ATPase inhibitor that prevents endosomal acidification. As UNC93A requires acidic conditions in endosomes to properly sort toll-like receptors, Concanamycin A's inhibition of V-ATPase results in the functional inhibition of UNC93A due to impaired endosomal pH regulation. | ||||||
Dynamin Inhibitor I, Dynasore | 304448-55-3 | sc-202592 | 10 mg | $87.00 | 44 | |
Dynasore inhibits dynamin, which is crucial for the endocytic process. Since UNC93A is involved in the endosomal system, dynamin inhibition impedes endosome formation and function, and thus, the role of UNC93A in toll-like receptor trafficking is inhibited. | ||||||
Hydroxy-Dynasore | 1256493-34-1 | sc-364678 | 10 mg | $250.00 | ||
Dyngo-4a is another dynamin inhibitor that blocks endocytosis. By preventing endosome recycling and formation, it inhibits the function of UNC93A by disrupting the endosomal pathway and toll-like receptor trafficking that relies on endocytosis. | ||||||
Pitstop 2 | 1419093-54-1 | sc-507418 | 10 mg | $360.00 | ||
Pitstop 2 is a clathrin-mediated endocytosis inhibitor that impedes the formation of clathrin-coated vesicles. Since UNC93A operates within the endosomal system, inhibiting clathrin-mediated endocytosis can disrupt toll-like receptor sorting and inhibit UNC93A function. | ||||||
Chlorpromazine | 50-53-3 | sc-357313 sc-357313A | 5 g 25 g | $60.00 $108.00 | 21 | |
Chlorpromazine is known to block clathrin-mediated endocytosis. By disrupting this pathway, the endosomal sorting and trafficking of toll-like receptors, a process in which UNC93A is involved, is inhibited, leading to functional inhibition of UNC93A. | ||||||
Ikarugamycin | 36531-78-9 | sc-202179 | 500 µg | $185.00 | 4 | |
Ikarugamycin inhibits clathrin-mediated endocytosis, which is essential for the proper trafficking and sorting of toll-like receptors in endosomes, a process that is dependent on the function of UNC93A. This inhibition leads to a reduction in UNC93A activity. | ||||||
Monensin A | 17090-79-8 | sc-362032 sc-362032A | 5 mg 25 mg | $152.00 $515.00 | ||
Monensin is an ionophore that disrupts endosomal ion gradients. The alteration in endosomal pH and ion homeostasis can inhibit the sorting function of UNC93A, as it relies on these gradients for proper toll-like receptor trafficking. | ||||||
Filipin III | 480-49-9 | sc-205323 sc-205323A | 500 µg 1 mg | $116.00 $145.00 | 26 | |
Filipin III binds to cholesterol and disrupts lipid rafts within cellular membranes. This disruption can inhibit the localization of toll-like receptors within endosomes, a process that is facilitated by UNC93A, thus functionally inhibiting UNC93A. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $26.00 $92.00 $120.00 $310.00 $500.00 $908.00 $1821.00 | 46 | |
Genistein is a tyrosine kinase inhibitor that can inhibit the phosphorylation of proteins involved in endocytic trafficking. As protein phosphorylation is critical for the function of endosomal sorting and toll-like receptor trafficking, this can lead to functional inhibition of UNC93A. | ||||||