UNC-13 Inhibitors
The proteins, channels, and pathways that contribute to synaptic vesicle exocytosis and neurotransmitter release are complex, intricate, and tightly interwoven. UNC-13, as a critical component of this machinery, is inevitably influenced by alterations or disturbances to any of these elements. UNC-13 inhibitors, such as Botulinum toxin and Tetanus toxin, target the SNARE complex and proteins, central players in synaptic vesicle fusion, thereby indirectly impacting UNC-13.
Others, like Lamotrigine and ω-Conotoxin GVIA, affect ion channels that play a role in initiating and modulating synaptic transmission, thereby altering the milieu in which UNC-13 operates. By affecting calcium dynamics, compounds like Ruthenium red, Dantrolene, and ω-Agatoxin IVA have the potential to influence UNC-13's calcium-dependent activities in vesicle priming.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Lamotrigine | 84057-84-1 | sc-201079 sc-201079A | 10 mg 50 mg | $118.00 $476.00 | 1 | |
An antiepileptic drug that inhibits voltage-sensitive sodium channels, potentially suppressing the neural activity that UNC-13 is involved in. | ||||||
Ruthenium red | 11103-72-3 | sc-202328 sc-202328A | 500 mg 1 g | $184.00 $245.00 | 13 | |
Inhibits calcium uptake in mitochondria, potentially affecting calcium-mediated events in synaptic vesicle priming involving UNC-13. | ||||||
Dantrolene | 7261-97-4 | sc-500165 | 25 mg | $350.00 | 7 | |
Interferes with calcium release from the endoplasmic reticulum. Altered intracellular calcium dynamics can influence UNC-13’s activity in vesicle priming. | ||||||
Bafilomycin A1 | 88899-55-2 | sc-201550 sc-201550A sc-201550B sc-201550C | 100 µg 1 mg 5 mg 10 mg | $96.00 $250.00 $750.00 $1428.00 | 280 | |
Specific inhibitor of vacuolar-type H+-ATPase, affecting vesicle acidification, potentially impacting vesicle priming mediated by UNC-13. | ||||||
D(−)-2-Amino-5-phosphonovaleric acid (D-AP5) | 79055-68-8 | sc-200434 | 5 mg | $95.00 | 2 | |
An NMDA receptor antagonist, impacting glutamatergic synaptic transmission and potentially UNC-13’s function in these synapses. | ||||||
ω-Agatoxin IVA | 145017-83-0 | sc-302015 | 100 µg | $454.00 | ||
Inhibits P/Q-type calcium channels, reducing calcium influx in presynaptic terminals and potentially affecting UNC-13’s vesicle priming role. | ||||||
KT 5720 | 108068-98-0 | sc-3538 sc-3538A sc-3538B | 50 µg 100 µg 500 µg | $97.00 $144.00 $648.00 | 47 | |
PKA inhibitor; by affecting cAMP-dependent pathways, it can indirectly influence UNC-13 activity in synaptic transmission. | ||||||