UNC-13 Activators
UNC-13 activators encompass a range of chemicals that modulate second messenger pathways, particularly those that increase intracellular cyclic adenosine monophosphate (cAMP). These compounds do not directly activate UNC-13 but influence the intracellular environment to a state that can indirectly enhance UNC-13's role in synaptic vesicle priming. The mode of action of these chemicals typically involves the inhibition of phosphodiesterases (PDEs) leading to elevated levels of cAMP, or the direct addition of cAMP analogs that mimic the natural activator's function within the cell.
By increasing cAMP, these compounds can activate protein kinase A (PKA), which may phosphorylate substrates that are involved in the regulation of synaptic vesicle dynamics and neurotransmitter release, where UNC-13 is a key player. The chemicals listed are known to either inhibit the breakdown of cAMP or act as analogs, providing sustained activation of PKA. This process can lead to a cascade of intracellular events culminating in the potentiation of synaptic transmission, which is the primary cellular process where UNC-13 operates.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Activates adenylate cyclase, increasing cAMP levels which can enhance neurotransmitter release potentially involving UNC-13. | ||||||
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $75.00 $212.00 | 18 | |
PDE4 inhibitor, increases cAMP by preventing its breakdown, possibly promoting UNC-13-mediated vesicle priming. | ||||||
8-Bromo-cAMP | 76939-46-3 | sc-201564 sc-201564A | 10 mg 50 mg | $97.00 $224.00 | 30 | |
A cAMP analog that can activate PKA, potentially increasing phosphorylation events that promote UNC-13 function. | ||||||
Arachidonic Acid (20:4, n-6) | 506-32-1 | sc-200770 sc-200770A sc-200770B | 100 mg 1 g 25 g | $90.00 $235.00 $4243.00 | 9 | |
As a modulator of synaptic function, it may influence membrane fusion processes involving UNC-13. | ||||||
Tadalafil | 171596-29-5 | sc-208412 | 50 mg | $176.00 | 13 | |
Another PDE5 inhibitor, with similar effects to Sildenafil, could indirectly enhance UNC-13 activity. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $45.00 $130.00 $480.00 $4450.00 | 74 | |
A cAMP analog that resists degradation and can mimic the effects of endogenous cAMP, potentially enhancing UNC-13 activity. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $159.00 $315.00 $598.00 | 34 | |
Non-selective PDE inhibitor, raises intracellular cAMP and cGMP levels, potentially modulating UNC-13 activity. | ||||||
Vinpocetine | 42971-09-5 | sc-201204 sc-201204A sc-201204B | 20 mg 100 mg 15 g | $55.00 $214.00 $2400.00 | 4 | |
A PDE1 inhibitor that could lead to increased cAMP and cGMP, thereby potentially influencing UNC-13 activity. | ||||||
Zaprinast (M&B 22948) | 37762-06-4 | sc-201206 sc-201206A | 25 mg 100 mg | $103.00 $245.00 | 8 | |
PDE5 inhibitor, increases cGMP levels which might interplay with cAMP pathways and affect UNC-13. | ||||||