UGT2B35 Inhibitors
UGT2B35 inhibitors are chemical compounds that specifically inhibit the activity of the enzyme UDP-glucuronosyltransferase 2B35 (UGT2B35). UGT enzymes, including UGT2B35, play a crucial role in the process of glucuronidation, a phase II metabolic pathway where glucuronic acid is attached to various endogenous and exogenous molecules. This process increases the hydrophilicity of molecules, facilitating their excretion through urine or bile. UGT2B35 is part of the UGT2 family, and its role is primarily associated with the metabolism of various small molecules, including steroids, bile acids, and other lipophilic compounds. Inhibitors of UGT2B35, therefore, can interfere with these metabolic processes by reducing or halting the conjugation of glucuronic acid to target molecules, potentially leading to alterations in the bioavailability or retention of certain substrates within biological systems.
Structurally, UGT2B35 inhibitors vary significantly, but they often possess molecular features that allow them to interact with the active site of the UGT2B35 enzyme, blocking access to the natural substrates. These inhibitors can act in a competitive or non-competitive manner, depending on whether they bind directly to the active site or an allosteric site of the enzyme. The mechanisms of inhibition are important in determining the efficacy and specificity of these compounds, as some may only inhibit UGT2B35 selectively, while others might affect a broader range of UGT enzymes. The study of UGT2B35 inhibitors provides insights into the enzyme's substrate specificity, structural dynamics, and the metabolic pathways regulated by glucuronidation. Additionally, such inhibitors are valuable in biochemical research for characterizing enzyme kinetics and understanding the broader role of glucuronidation in metabolism.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Actinomycin D | 50-76-0 | sc-200906 sc-200906A sc-200906B sc-200906C sc-200906D | 5 mg 25 mg 100 mg 1 g 10 g | $74.00 $243.00 $731.00 $2572.00 $21848.00 | 53 | |
Actinomycin D inhibits the expression of UDP glucuronosyltransferase 2 family, polypeptide B35 by intercalating into DNA, preventing transcription initiation and elongation, thereby blocking the synthesis of mRNA. | ||||||
α-Amanitin | 23109-05-9 | sc-202440 sc-202440A | 1 mg 5 mg | $269.00 $1050.00 | 26 | |
α-Amanitin inhibits the expression of UDP glucuronosyltransferase 2 family, polypeptide B35 by binding to RNA polymerase II, blocking transcriptional elongation and leading to reduced mRNA levels. | ||||||
Cycloheximide | 66-81-9 | sc-3508B sc-3508 sc-3508A | 100 mg 1 g 5 g | $41.00 $84.00 $275.00 | 127 | |
Cycloheximide inhibits the expression of UDP glucuronosyltransferase 2 family, polypeptide B35 by binding to the 60S ribosomal subunit, blocking peptide bond formation during translation, resulting in decreased protein synthesis. | ||||||
Rifampicin | 13292-46-1 | sc-200910 sc-200910A sc-200910B sc-200910C | 1 g 5 g 100 g 250 g | $97.00 $328.00 $676.00 $1467.00 | 6 | |
Rifampicin inhibits the expression of UDP glucuronosyltransferase 2 family, polypeptide B35 by binding to bacterial RNA polymerase, blocking transcription initiation and indirectly reducing mRNA levels. | ||||||
Thiolutin | 87-11-6 | sc-200387 sc-200387A | 1 mg 5 mg | $101.00 $406.00 | 1 | |
Thiolutin inhibits the expression of UDP glucuronosyltransferase 2 family, polypeptide B35 by binding to RNA polymerase and blocking transcriptional elongation, resulting in reduced mRNA synthesis and protein expression. | ||||||
Cordycepin | 73-03-0 | sc-203902 | 10 mg | $101.00 | 5 | |
Cordycepin inhibits the expression of UDP glucuronosyltransferase 2 family, polypeptide B35 by being incorporated into mRNA during transcription, leading to premature termination of transcription and reduced mRNA levels. | ||||||
Puromycin dihydrochloride | 58-58-2 | sc-108071 sc-108071B sc-108071C sc-108071A | 25 mg 250 mg 1 g 50 mg | $42.00 $214.00 $832.00 $66.00 | 394 | |
Puromycin inhibits the expression of UDP glucuronosyltransferase 2 family, polypeptide B35 by incorporating into growing polypeptide chains during translation, causing premature termination and synthesis of truncated proteins. | ||||||
Siomycin A | 12656-09-6 | sc-202339 sc-202339-CW sc-202339A sc-202339B | 500 µg 500 µg 2.5 mg 25 mg | $450.00 $500.00 $1350.00 $10404.00 | 4 | |
Siomycin A inhibits the expression of UDP glucuronosyltransferase 2 family, polypeptide B35 by binding to RNA polymerase and preventing the formation of the transcription complex, leading to transcriptional arrest. | ||||||
Homoharringtonine | 26833-87-4 | sc-202652 sc-202652A sc-202652B | 1 mg 5 mg 10 mg | $52.00 $125.00 $182.00 | 11 | |
Homoharringtonine inhibits the expression of UDP glucuronosyltransferase 2 family, polypeptide B35 by binding to the ribosome and inhibiting protein synthesis, resulting in decreased levels of the target protein. | ||||||