Molecular structure of Siomycin A, CAS Number: 12656-09-6
Siomycin A (CAS 12656-09-6)
See product citations (4)
Alternate Names:
Mutabilycin; Sporangiomycin
Application:
Siomycin A is an antibiotic that inhibits FoxM1
CAS Number:
12656-09-6
Purity:
>95%
Molecular Weight:
1648.80
Molecular Formula:
C71H81N19O18S5
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
QUICK LINKS
Ordering Information
Product Citations
Description
Technical Information
Safety Information
SDS & Certificate of Analysis
Siomycin A, an antibiotic thiazole compound, may act to down-regulate the mRNA and protein abundance as well as transcriptional activity of transcription factor forkhead box M1 (FoxM1). Consequentially, it was demonstrated that the downstream target genes of FoxM1, such as CENP-B, Survivin, and Cdc25B were repressed. This compound was also reported to induce potent p53-independent apoptosis in cancer cell lines of different origin. Siomycin A is an inhibitor of FOXM1.
Siomycin A (CAS 12656-09-6) References
- Identification of a chemical inhibitor of the oncogenic transcription factor forkhead box M1. | Radhakrishnan, SK., et al. 2006. Cancer Res. 66: 9731-5. PMID: 17018632
- Total synthesis of siomycin A: construction of synthetic segments. | Mori, T., et al. 2008. Chem Asian J. 3: 984-1012. PMID: 18464237
- Novel anticancer compounds induce apoptosis in melanoma cells. | Bhat, UG., et al. 2008. Cell Cycle. 7: 1851-5. PMID: 18583930
- Thiopeptide biosynthesis featuring ribosomally synthesized precursor peptides and conserved posttranslational modifications. | Liao, R., et al. 2009. Chem Biol. 16: 141-7. PMID: 19246004
- Thiazole antibiotics target FoxM1 and induce apoptosis in human cancer cells. | Bhat, UG., et al. 2009. PLoS One. 4: e5592. PMID: 19440351
- FoxM1 is a general target for proteasome inhibitors. | Bhat, UG., et al. 2009. PLoS One. 4: e6593. PMID: 19672316
- New potential anti-cancer agents synergize with bortezomib and ABT-737 against prostate cancer. | Pandit, B. and Gartel, AL. 2010. Prostate. 70: 825-33. PMID: 20058240
- Proteasome inhibitory activity of thiazole antibiotics. | Pandit, B., et al. 2011. Cancer Biol Ther. 11: 43-7. PMID: 21119308
- Siomycin A targets brain tumor stem cells partially through a MELK-mediated pathway. | Nakano, I., et al. 2011. Neuro Oncol. 13: 622-34. PMID: 21558073
- Thiazole Antibiotics Siomycin a and Thiostrepton Inhibit the Transcriptional Activity of FOXM1. | Gartel, AL. 2013. Front Oncol. 3: 150. PMID: 23761863
- FOXM1: A novel drug target in gastroenteropancreatic neuroendocrine tumors. | Briest, F., et al. 2015. Oncotarget. 6: 8185-99. PMID: 25797272
- Siomycin A Induces Apoptosis in Human Lung Adenocarcinoma A549 Cells by Suppressing the Expression of FoxM1. | Guo, X., et al. 2015. Nat Prod Commun. 10: 1603-6. PMID: 26594769
- Effects and mechanism of siomycin A on the growth and apoptosis of MiaPaCa-2 cancer cells. | Wang, B., et al. 2019. Oncol Lett. 18: 2869-2876. PMID: 31452766
- Siomycin A induces reactive oxygen species-mediated cytotoxicity in ovarian cancer cells. | Shao, X., et al. 2021. Oncol Lett. 21: 431. PMID: 33868469
- FOXM1 inhibitor, Siomycin A, synergizes and restores 5-FU cytotoxicity in human cholangiocarcinoma cell lines via targeting thymidylate synthase. | Klinhom-On, N., et al. 2021. Life Sci. 286: 120072. PMID: 34688691
Inhibitor of:
2310057J18Rik, 3010026O09Rik, Aminopeptidase P1, C78339, Cdc14, CGI-99_2700060E02Rik, CGNL1, CTL5, cyclin O, EBP2, fish, FOXD4L3, FOXM1, FTCD, GFRα-1, GPI-PLD, HARE, HMBOX1, hnRNP A2/B1, HNRNPA1L2, HS6ST1, Klk1b3, Klra33, Ku, LOC100040307, LOC100041032, LOC145837, LOC439994, MUP19, PCDHGA8, R3HCC1, Rad54, RNA pol σ S, RP23-221K3.2, TACC3, TAF II p100, TCEAL7, TrpRS, U90926, Ubie, Ubie3, UGT2B34, UGT2B35, V1RA7, V1RA8, V1RB3, vezatin, ZBTB8OS, ZNF704, and ZNF827.Activator of:
Nup88.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Siomycin A, 500 µg | sc-202339 | 500 µg | $439.00 | |||
Siomycin A, 500 µg | sc-202339-CW | 500 µg | $449.00 | |||
Siomycin A, 2.5 mg | sc-202339A | 2.5 mg | $1326.00 | |||
Siomycin A, 25 mg | sc-202339B | 25 mg | $10200.00 |