Date published: 2025-10-22

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UFD2 Inhibitors

The UFD2 inhibitors belong to a distinct chemical class that specifically targets the UFD2 enzyme, a key player in cellular processes. These inhibitors are designed to modulate the activity of UFD2 by binding to its active site or other functional regions, thereby influencing its function. UFD2 itself is involved in ubiquitin-mediated protein degradation, a crucial mechanism for maintaining cellular protein homeostasis and quality control.

By interacting with UFD2, these inhibitors have the potential to impact the degradation of ubiquitinated proteins and subsequently influence various cellular pathways. The development and study of UFD2 inhibitors contribute to advancing our understanding of intracellular protein degradation mechanisms and may have implications for various biological processes.

SEE ALSO...

Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

MLN 4924

905579-51-3sc-484814
1 mg
$280.00
1
(0)

Originally developed as an inhibitor of NEDD8-activating enzyme, MLN4924 also indirectly inhibits UFD2, leading to the accumulation of ubiquitinated proteins and apoptosis in cancer cells.

Thiostrepton

1393-48-2sc-203412
sc-203412A
1 g
5 g
$115.00
$415.00
10
(1)

An antibiotic that has been reported to inhibit UFD2-mediated proteasomal degradation, which might be relevant in cancer therapy.

Fluorouracil

51-21-8sc-29060
sc-29060A
1 g
5 g
$36.00
$149.00
11
(1)

An antimetabolite has been suggested that 5-Fluorouracil might inhibit UFD2 and promote protein degradation.

Bortezomib

179324-69-7sc-217785
sc-217785A
2.5 mg
25 mg
$132.00
$1064.00
115
(2)

While primarily known as a proteasome inhibitor, bortezomib indirectly affects UFD2 by altering the proteasomal degradation landscape.

Cycloheximide

66-81-9sc-3508B
sc-3508
sc-3508A
100 mg
1 g
5 g
$40.00
$82.00
$256.00
127
(5)

An inhibitor of protein synthesis that can indirectly influence UFD2-mediated protein degradation by affecting the availability of substrates.

P005091

882257-11-6sc-478535
10 mg
$155.00
(0)

This inhibitor has been shown to block the deubiquitinating activity of UFD2, leading to proteasome-dependent protein degradation.

P22077

1247819-59-5sc-478536
10 mg
$162.00
(0)

An inhibitor of UFD2's deubiquitinating activity, which may impact protein degradation pathways.

Pyrvinium Pamoate

3546-41-6sc-476920A
sc-476920
250 mg
500 mg
$224.00
$414.00
(0)