UFD2 Activators
UFD2 activators refers to a specific chemical class characterized by its ability to modulate the activity of the ubiquitin fusion degradation 2 (UFD2) protein. The UFD2 protein plays a crucial role in cellular processes, particularly in the ubiquitin-proteasome system, which is responsible for the targeted degradation of proteins. The ubiquitin-proteasome system is an essential mechanism for maintaining cellular homeostasis by regulating the levels of various proteins. UFD2, as part of this system, serves as a key component in recognizing and tagging proteins for degradation.
Chemically, UFD2 activators are designed to interact with the UFD2 protein, influencing its function and subsequently impacting the overall protein degradation process. These activators are engineered to enhance or modulate the activity of UFD2, leading to a more efficient degradation of specific proteins targeted by the ubiquitin-proteasome system. The intricate molecular interactions between UFD2 activators and the UFD2 protein contribute to the fine-tuning of cellular protein levels, with potential implications for cellular function and regulation. The development and study of UFD2 activators represent a facet of research aimed at understanding the molecular mechanisms governing protein degradation within cells, shedding light on the intricate network of cellular processes that contribute to overall cellular health and function.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
N-Ethylmaleimide | 128-53-0 | sc-202719A sc-202719 sc-202719B sc-202719C sc-202719D | 1 g 5 g 25 g 100 g 250 g | $22.00 $69.00 $214.00 $796.00 $1918.00 | 19 | |
N-Ethylmaleimide is a sulfhydryl reactive compound that can inhibit deubiquitinating enzymes (DUBs), which are responsible for removing ubiquitin from protein substrates. Inhibition of DUBs can enhance the function of UFD2 by preventing the removal of ubiquitin chains that UFD2 facilitates, thereby stabilizing its substrates' ubiquitination state. | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $60.00 $265.00 $1000.00 | 163 | |
MG132 is a proteasome inhibitor that can lead to the accumulation of ubiquitinated proteins. By inhibiting the degradation pathway, it indirectly enhances the activity of UFD2 by increasing the substrate availability for ubiquitination. | ||||||
Ubiquitin E1 Inhibitor, PYR-41 | 418805-02-4 | sc-358737 | 25 mg | $360.00 | 4 | |
Pyr41 is a selective inhibitor of the ubiquitin-activating enzyme E1. By inhibiting upstream activities in the ubiquitination cascade, Pyr41 can indirectly increase the functional activity of UFD2 by causing an accumulation of partially ubiquitinated substrates that require further chain elongation, a process mediated by UFD2. | ||||||
Lactacystin | 133343-34-7 | sc-3575 sc-3575A | 200 µg 1 mg | $188.00 $575.00 | 60 | |
Lactacystin is a specific inhibitor of the proteasome. By preventing the degradation of ubiquitin-conjugated proteins, it can indirectly enhance the function of UFD2 by increasing the demand for its chain-elongation function. | ||||||
Thalidomide | 50-35-1 | sc-201445 sc-201445A | 100 mg 500 mg | $111.00 $357.00 | 8 | |
Thalidomide is known to induce the degradation of specific proteins via the ubiquitin-proteasome system. It indirectly enhances UFD2 activity by increasing the level of proteins that require ubiquitination and subsequent degradation, which UFD2 can facilitate. | ||||||
Tunicamycin | 11089-65-9 | sc-3506A sc-3506 | 5 mg 10 mg | $172.00 $305.00 | 66 | |
Tunicamycin inhibits N-linked glycosylation, leading to ER stress and the upregulation of ER-associated degradation (ERAD) pathway components. UFD2 is involved in ERAD by extending ubiquitin chains on misfolded ER proteins, so tunicamycin can indirectly enhance UFD2 activity. | ||||||
Leupeptin hemisulfate | 103476-89-7 | sc-295358 sc-295358A sc-295358D sc-295358E sc-295358B sc-295358C | 5 mg 25 mg 50 mg 100 mg 500 mg 10 mg | $73.00 $148.00 $316.00 $499.00 $1427.00 $101.00 | 19 | |
Leupeptin is an inhibitor of certain proteases, including those of the lysosome. It can lead to increased levels of proteins that are degraded by lysosomes, which could increase the functional demand on the ubiquitin-proteasome system where UFD2 functions. | ||||||
Geldanamycin | 30562-34-6 | sc-200617B sc-200617C sc-200617 sc-200617A | 100 µg 500 µg 1 mg 5 mg | $39.00 $59.00 $104.00 $206.00 | 8 | |
Geldanamycin binds to heat shock protein 90 (Hsp90) and inhibits its function. This can lead to the destabilization and subsequent degradation of Hsp90 client proteins, potentially enhancing the activity of UFD2 by increasing the number of substrates requiring ubiquitin chain elongation. | ||||||