ubiquitous kinesin heavy chain Inhibitors
Chemical inhibitors of ubiquitous kinesin heavy chain can interfere with its function by targeting proteins that are structurally and functionally related to it, thereby indirectly affecting its activity. Monastrol, a small molecule inhibitor, impedes the function of the motor protein kinesin Eg5 by binding to its motor domain, which leads to the disruption of mitotic spindle formation-a process in which the ubiquitous kinesin heavy chain is implicated. Similarly, Dimethylenastron restricts the microtubule-binding ability of Eg5, thereby hindering its motor activity and consequently influencing the dynamics of microtubules to which the ubiquitous kinesin heavy chain contributes. Ispinesib and Filanesib, both selective inhibitors of kinesin spindle protein (KSP), assert their effects by binding to the ATP-binding pocket of KSP, resulting in the inhibition of ATPase activity. This action can disrupt the dynamics of microtubules and the formation of the mitotic spindle, processes essential to the functionality of the ubiquitous kinesin heavy chain.
Other chemical inhibitors, such as S-Trityl-L-cysteine, target Eg5 and obstruct its motor activity, which is important for maintaining spindle bipolarity during cell division, a critical aspect of ubiquitous kinesin heavy chain's role. AZ82, an inhibitor of kinesin-like protein KIFC1, by inhibiting KIFC1's motor activity, can alter the intracellular transport and localization of vesicles and organelles, affecting the cellular transport machinery where ubiquitous kinesin heavy chain is a key player. Paprotrain, targeting the mitotic kinesin MCAK, can influence microtubule turnover, a process in which ubiquitous kinesin heavy chain also participates. Additionally, BI-D1870, by inhibiting ribosomal S6 kinase (RSK), can change the phosphorylation state of proteins involved in the regulation of microtubule dynamics and the cell cycle, indirectly impacting the function of ubiquitous kinesin heavy chain. Lastly, GSK923295, a selective inhibitor of centromere-associated protein-E (CENP-E), by disrupting the function of CENP-E during chromosome congression in mitosis, can have an indirect effect on the overall function of motor proteins, including ubiquitous kinesin heavy chain.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Monastrol | 254753-54-3 | sc-202710 sc-202710A | 1 mg 5 mg | $120.00 $233.00 | 10 | |
Monastrol is a cell-permeable small molecule inhibitor of the motor protein kinesin Eg5, which is related to ubiquitous kinesin heavy chain. By binding to the motor domain of Eg5, Monastrol impairs the function of Eg5, leading to the inhibition of its ATPase activity and the subsequent disruption of the mitotic spindle formation. This mechanism can indirectly inhibit the function of ubiquitous kinesin heavy chain by perturbing the mitotic spindle dynamics which it is implicated in. | ||||||
Eg5 Inhibitor III, Dimethylenastron | 863774-58-7 | sc-221576 sc-221576A sc-221576B sc-221576C | 1 mg 5 mg 10 mg 25 mg | $38.00 $132.00 $244.00 $516.00 | 1 | |
Dimethylenastron is a potent inhibitor of kinesin Eg5, which shares structural and functional similarities with ubiquitous kinesin heavy chain. It operates by interfering with the microtubule-binding ability of Eg5, leading to a blockade of its motor activity. This inhibition of Eg5 can indirectly lead to a reduced activity of ubiquitous kinesin heavy chain by destabilizing microtubule-associated processes that are essential for its function. | ||||||
Ispinesib | 336113-53-2 | sc-364747 | 10 mg | $505.00 | ||
Ispinesib selectively targets kinesin spindle protein (KSP), a kinesin family member closely related to ubiquitous kinesin heavy chain. It binds to the ATP-binding pocket of KSP, leading to the inhibition of its ATPase activity. This inhibition can indirectly affect the ubiquitous kinesin heavy chain by altering the dynamics of microtubules, which are critical for the functioning of various kinesin family members, including the ubiquitous kinesin heavy chain. | ||||||
S-Trityl-L-cysteine | 2799-07-7 | sc-202799 sc-202799A | 1 g 5 g | $32.00 $66.00 | 6 | |
S-Trityl-L-cysteine is a synthetic compound that acts as an inhibitor of Eg5, a mitotic kinesin similar to ubiquitous kinesin heavy chain. By binding to the Eg5 motor domain, it inhibits its motor activity, which is crucial for spindle bipolarity during cell division. This can indirectly inhibit ubiquitous kinesin heavy chain activity by altering the mitotic spindle dynamics and cell division processes that rely on functional kinesin motors. | ||||||
BI-D1870 | 501437-28-1 | sc-397022 sc-397022A | 1 mg 5 mg | $92.00 $260.00 | 12 | |
BI-D1870 is an inhibitor of RSK (ribosomal S6 kinase), which phosphorylates various downstream targets involved in cell growth and survival. Inhibition of RSK can lead to changes in microtubule dynamics and cell cycle regulation, processes that are essential for the function of motor proteins like ubiquitous kinesin heavy chain. | ||||||
GSK 923295 | 1088965-37-0 | sc-490136 | 5 mg | $290.00 | ||
GSK923295 is a centromere-associated protein-E (CENP-E) inhibitor, a kinesin motor protein that is crucial for the proper congression of chromosomes during mitosis. By selectively inhibiting CENP-E, GSK923295 can indirectly inhibit ubiquitous kinesin heavy chain by impacting chromosome alignment and segregation, which may influence the overall function of motor proteins | ||||||