Molecular structure of Eg5 Inhibitor III, Dimethylenastron, CAS Number: 863774-58-7
Eg5 Inhibitor III, Dimethylenastron (CAS 863774-58-7)
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Alternate Names:
2,3,4,6,7,8-hexahydro-4-(3-hydroxyphenyl)-7,7-dimethyl-2-thioxo-5(1H)-quinazolinone
Application:
Eg5 Inhibitor III, Dimethylenastron is a cell-permeable quinazoline-thione compound
CAS Number:
863774-58-7
Molecular Weight:
302.40
Molecular Formula:
C16H18N2O2S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Eg5 Inhibitor III, Dimethylenastron is a cell-permeable quinazoline-thione compound that acts as a strong, specific, and reversible inhibitor of the microtubule-stimulated ATPase activity of the mitotic motor, Eg5. Eg5 Inhibitor III, Dimethylenastron shows little effect on the ATPase activity of kinesin-1, -4, -7 and -10. The compound also inhibits bipolar spindle formation in both HeLa cells and in Xenopus egg extracts and induces cell cycle arrest (~1 µM). Eg5 Inhibitor III, Dimethylenastron is shown to induce mitotic arrest, apoptosis and upregulate Hsp70 in human multiple myeloma cells.
Eg5 Inhibitor III, Dimethylenastron (CAS 863774-58-7) References
- Development and biological evaluation of potent and specific inhibitors of mitotic Kinesin Eg5. | Gartner, M., et al. 2005. Chembiochem. 6: 1173-7. PMID: 15912555
- Inhibition of the mitotic kinesin Eg5 up-regulates Hsp70 through the phosphatidylinositol 3-kinase/Akt pathway in multiple myeloma cells. | Liu, M., et al. 2006. J Biol Chem. 281: 18090-7. PMID: 16627469
- Myosin IIA regulates cell motility and actomyosin-microtubule crosstalk. | Even-Ram, S., et al. 2007. Nat Cell Biol. 9: 299-309. PMID: 17310241
- Microtubules do not promote mitotic slippage when the spindle assembly checkpoint cannot be satisfied. | Brito, DA., et al. 2008. J Cell Biol. 182: 623-9. PMID: 18710927
- Habituation-Like Decrease of Acetylcholine-Induced Inward Current in Helix Command Neurons: Role of Microtubule Motor Proteins. | Vasil'yeva, NA., et al. 2015. Cell Mol Neurobiol. 35: 703-12. PMID: 25687906
- Gamma-actin is involved in regulating centrosome function and mitotic progression in cancer cells. | Po'uha, ST. and Kavallaris, M. 2015. Cell Cycle. 14: 3908-19. PMID: 26697841
- Incoming human papillomavirus type 16 genome resides in a vesicular compartment throughout mitosis. | DiGiuseppe, S., et al. 2016. Proc Natl Acad Sci U S A. 113: 6289-94. PMID: 27190090
- 53BP1 and USP28 mediate p53-dependent cell cycle arrest in response to centrosome loss and prolonged mitosis. | Fong, CS., et al. 2016. Elife. 5: PMID: 27371829
- Human Papillomavirus Major Capsid Protein L1 Remains Associated with the Incoming Viral Genome throughout the Entry Process. | DiGiuseppe, S., et al. 2017. J Virol. 91: PMID: 28566382
- Orabase-formulated gentian violet effectively improved oral potentially malignant disorder in vitro and in vivo. | Wang, YY., et al. 2020. Biochem Pharmacol. 171: 113713. PMID: 31733192
Inhibitor of:
4930534B04Rik, 5830418K08Rik, ATPase, C16orf57, centlein, Centrobin, CEP152, CKAP5, D14Ertd500e, DNAH1, EG231836, Eg5, KIAA1009, KIF6, Kinesin, kinesin light chain, KLC, MDM1, neuronal kinesin heavy chain, NuMA, PC-PLD2B, SPANX-N1, and ubiquitous kinesin heavy chain.Activator of:
α9-nAChR, Cdc11, Eg5, KIF4A, and NAG.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Eg5 Inhibitor III, Dimethylenastron, 1 mg | sc-221576 | 1 mg | $38.00 | |||
Eg5 Inhibitor III, Dimethylenastron, 5 mg | sc-221576A | 5 mg | $132.00 | |||
Eg5 Inhibitor III, Dimethylenastron, 10 mg | sc-221576B | 10 mg | $244.00 | |||
Eg5 Inhibitor III, Dimethylenastron, 25 mg | sc-221576C | 25 mg | $516.00 |