UBE2J2 Activators
UBE2J2 activators encompass a category of compounds that are involved in the modulation of the protein UBE2J2, which is an E2 ubiquitin-conjugating enzyme. This enzyme plays a critical part in the ubiquitination pathway, a cellular process that marks proteins for degradation or regulates their function through the attachment of ubiquitin molecules. UBE2J2 is particularly implicated in endoplasmic reticulum-associated degradation (ERAD), which targets misfolded proteins in the endoplasmic reticulum for ubiquitination and subsequent destruction. These activators can exert their influence through direct interactions or through indirect means that increase the enzymatic activity of UBE2J2.
Direct activators may bind to specific regions on UBE2J2, thereby enhancing its ability to interact with ubiquitin or ubiquitin-like proteins, or improving its association with E1 ubiquitin-activating enzymes and E3 ubiquitin ligases. This binding might alter the enzyme's conformation to a more active state, making it more efficient in catalyzing the transfer of ubiquitin to substrate proteins. On the other hand, indirect activators may influence the expression levels of UBE2J2 by modulating the transcription factors responsible for its gene expression, or by stabilizing the mRNA to increase protein translation. Additionally, they could affect the protein stability of UBE2J2, preventing its degradation and thus maintaining higher levels of the enzyme within the cell. These activators may also enhance UBE2J2 activity by influencing the levels of cofactors or other proteins that interact with UBE2J2, facilitating its proper localization to the endoplasmic reticulum or its involvement in the ubiquitin-proteasome system.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $56.00 $260.00 $980.00 | 163 | |
MG132 is a proteasome inhibitor. By inhibiting the proteasome, it prevents the degradation of ubiquitinated proteins, which indirectly increases the demand for ubiquitin-conjugating enzymes like UBE2J2. This can enhance the activity of UBE2J2 by increasing its utility in the cell. | ||||||
Bortezomib | 179324-69-7 | sc-217785 sc-217785A | 2.5 mg 25 mg | $132.00 $1064.00 | 115 | |
Bortezomib is a proteasome inhibitor. By preventing the degradation of ubiquitinated proteins, it increases the need for ubiquitin-conjugating enzymes like UBE2J2, thereby enhancing its activity. | ||||||
Carfilzomib | 868540-17-4 | sc-396755 | 5 mg | $40.00 | ||
Carfilzomib is a proteasome inhibitor. It enhances the activity of UBE2J2 by preventing the degradation of ubiquitinated proteins, thereby increasing the demand for ubiquitin-conjugating enzymes like UBE2J2. | ||||||
Ixazomib | 1072833-77-2 | sc-489103 sc-489103A | 10 mg 50 mg | $311.00 $719.00 | ||
MLN2238, also known as Ixazomib, is a proteasome inhibitor. By preventing the degradation of ubiquitinated proteins, it indirectly enhances the activity of UBE2J2 by increasing its utility in the cell. | ||||||
Ubiquitin E1 Inhibitor, PYR-41 | 418805-02-4 | sc-358737 | 25 mg | $360.00 | 4 | |
Pyr-41 is a ubiquitin-activating enzyme E1 inhibitor. It can indirectly enhance the activity of UBE2J2 by increasing the concentration of free ubiquitin available for conjugation. | ||||||
Radicicol | 12772-57-5 | sc-200620 sc-200620A | 1 mg 5 mg | $90.00 $326.00 | 13 | |
Radicicol is an Hsp90 inhibitor. By inhibiting Hsp90, it leads to the accumulation of misfolded proteins which need to be ubiquitinated and degraded. This can enhance the activity of UBE2J2 by increasing its demand in the cell. | ||||||
Geldanamycin | 30562-34-6 | sc-200617B sc-200617C sc-200617 sc-200617A | 100 µg 500 µg 1 mg 5 mg | $38.00 $58.00 $102.00 $202.00 | 8 | |
Geldanamycin is an Hsp90 inhibitor that can enhance the activity of UBE2J2. By inhibiting Hsp90, it increases the accumulation of misfolded proteins which need to be ubiquitinated and degraded. | ||||||
Tunicamycin | 11089-65-9 | sc-3506A sc-3506 | 5 mg 10 mg | $169.00 $299.00 | 66 | |
Tunicamycin is an inhibitor of N-linked glycosylation. By inhibiting N-linked glycosylation, it leads to the accumulation of misfolded proteins which need to be ubiquitinated. This can enhance the activity of UBE2J2 by increasing the demand for its function. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $94.00 $349.00 | 114 | |
Thapsigargin is a SERCA inhibitor that causes ER stress. By causing ER stress, it leads to the accumulation of misfolded proteins which need to be ubiquitinated, thereby enhancing the activity of UBE2J2. | ||||||
DBeQ | 177355-84-9 | sc-499943 | 10 mg | $330.00 | 1 | |
DBeQ is a p97 inhibitor. By inhibiting p97, it leads to the accumulation of ubiquitinated proteins, which indirectly enhances the functional activity of UBE2J2 by increasing the demand for its function. | ||||||