TUSC3 Activators
TUSC3 Activators are a diverse set of chemical compounds that indirectly amplify the functional activity of TUSC3 through various biochemical mechanisms. The activity of TUSC3, a protein known for its role in thiol oxidoreductase activity and metal ion homeostasis in the endoplasmic reticulum, is bolstered by N-Acetylcysteine, which provides essential cysteine residues. Similarly, the presence of ZincSulfate and Magnesium Chloride enhances the metallophosphoesterase activity of TUSC3, supplying Zn2+ and Mg2+ ions necessary for its enzymatic functions, respectively. Selenium, sourced from Sodium Selenite, contributes to an antioxidant environment, indirectly supporting TUSC3's role in redox reactions, while Pyridoxal Phosphate and reduced Glutathione ensure a balanced cellular milieu for amino acid metabolism and maintenance of the redox state, crucial for TUSC3 activity. Manganese(II) Chloride and Copper(II) Sulfate provide Mn2+ and Cu2+ ions, which could act as cofactors to further potentiate TUSC3's phosphatase activity within the cell.
Moreover, TUSC3's activity is intricately connected to the cellular redox state and metal ion availability, with compounds like EDTA fine-tuning this balance by chelating excess metal ions and preventing inhibitory interactions. Cellular metabolites such as α-Ketoglutarate also play a subtle role by participating in metabolic processes that intersect with the pathway of TUSC3, thus indirectly influencing its activity. Folic Acid underpins one-carbon metabolism pathways that are foundational for TUSC3 function, and Riboflavin, as a precursor to FAD and FMN, aids in sustaining an optimal redox environment. Collectively, these activators enhance TUSC3's ability to modulate phosphatase activity and maintain metal ion homeostasis, ensuring its proper function in the cellular context.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
N-Acetyl-L-cysteine | 616-91-1 | sc-202232 sc-202232A sc-202232C sc-202232B | 5 g 25 g 1 kg 100 g | $34.00 $74.00 $270.00 $114.00 | 34 | |
N-Acetyl-L-cysteine, through its thiol group, provides cysteine, which is crucial for the function of TUSC3 as a thiol oxidoreductase. This leads to the maintenance of metal ion homeostasis in the endoplasmic reticulum, enhancing TUSC3 activity. | ||||||
Zinc | 7440-66-6 | sc-213177 | 100 g | $48.00 | ||
Zinc Sulfate provides Zn2+ ions, which are necessary cofactors for TUSC3's metallophosphoesterase activity. By increasing the available Zn2+ concentration, the enzymatic activity of TUSC3 in dephosphorylation reactions is enhanced. | ||||||
Magnesium chloride | 7786-30-3 | sc-255260C sc-255260B sc-255260 sc-255260A | 10 g 25 g 100 g 500 g | $28.00 $35.00 $48.00 $125.00 | 2 | |
Magnesium Chloride provides Mg2+ ions, which are essential for stabilizing phosphorylated intermediates in enzymatic reactions. The presence of Mg2+ enhances the phosphatase activity of TUSC3. | ||||||
Sodium selenite | 10102-18-8 | sc-253595 sc-253595B sc-253595C sc-253595A | 5 g 500 g 1 kg 100 g | $49.00 $183.00 $316.00 $98.00 | 3 | |
Sodium Selenite acts as a source of selenium, which is a component of selenoproteins that are involved in redox reactions and antioxidant defense. It indirectly supports TUSC3 function by maintaining a redox environment that is conducive to its activity. | ||||||
Pyridoxal-5-phosphate | 54-47-7 | sc-205825 | 5 g | $104.00 | ||
Pyridoxal Phosphate (PLP) serves as a cofactor for a wide range of enzymatic reactions, including those involving amino acid metabolism. PLP can indirectly enhance TUSC3 activity by maintaining the balance of amino acids necessary for its function. | ||||||
Glutathione, reduced | 70-18-8 | sc-29094 sc-29094A | 10 g 1 kg | $82.00 $2091.00 | 8 | |
Glutathione in its reduced form maintains the redox state within the cell, which is essential for TUSC3's role in regulating protein folding and metal ion homeostasis in the endoplasmic reticulum. | ||||||
Manganese(II) chloride beads | 7773-01-5 | sc-252989 sc-252989A | 100 g 500 g | $19.00 $31.00 | ||
Manganese(II) Chloride provides Mn2+ ions which can act as cofactors for TUSC3, potentially enhancing its phosphatase activity. | ||||||
Copper(II) sulfate | 7758-98-7 | sc-211133 sc-211133A sc-211133B | 100 g 500 g 1 kg | $46.00 $122.00 $189.00 | 3 | |
Copper(II) Sulfate supplies Cu2+ ions, which can serve as essential cofactors for various enzymes, including phosphatases like TUSC3, hence potentially enhancing its activity. | ||||||
α-Ketoglutaric Acid | 328-50-7 | sc-208504 sc-208504A sc-208504B sc-208504C sc-208504D sc-208504E sc-208504F | 25 g 100 g 250 g 500 g 1 kg 5 kg 16 kg | $33.00 $43.00 $63.00 $110.00 $188.00 $738.00 $2091.00 | 2 | |
α-Ketoglutarate is involved in the Krebs cycle and is also a co-substrate for dioxygenases that regulate gene expression and DNA repair. It could indirectly enhance TUSC3 activity by affecting these processes. | ||||||
Folic Acid | 59-30-3 | sc-204758 | 10 g | $73.00 | 2 | |
Folic Acid is crucial for one-carbon metabolism and thus indirectly supports TUSC3's function in the cell by supporting proper folate-dependent metabolic pathways that could interface with TUSC3 activity. | ||||||