TULA Inhibitors
Chemical inhibitors of TULA function primarily through the disruption of protein interactions and signaling pathways that TULA regulates. Dasatinib, SU6656, Bosutinib, Saracatinib, and PD173955 are notable examples that inhibit Src family kinases, which are key to TULA's regulatory role. By targeting these kinases, these inhibitors can disrupt the normal regulatory function of TULA. PP2, sharing a similar mechanism, also inhibits Src family kinases, thereby impeding TULA's ability to modulate signaling pathways involving these kinases. This inhibition can alter the protein's regulatory effects on cellular signaling cascades.
Continuing with the theme of kinase inhibition, Go6976, while known as a protein kinase C inhibitor, has also been identified as an inhibitor of Src family kinases, further contributing to the functional inhibition of TULA. Herbimycin A and Geldanamycin target the Hsp90 chaperone complex, indirectly affecting TULA by destabilizing proteins that interact with TULA or are crucial for its regulation. Inhibition by these chemicals can disrupt the proper folding and function of TULA. Additionally, K252a, with its broad-spectrum kinase inhibition, including Trk receptors, can indirectly affect TULA's activity given the protein's regulatory interactions with these kinases. Staurosporine, a potent and broad kinase inhibitor, extends its effects to a wide range of kinases, some of which are upstream of TULA, potentially altering TULA's role in cellular signaling pathways.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Dasatinib | 302962-49-8 | sc-358114 sc-358114A | 25 mg 1 g | $70.00 $145.00 | 51 | |
Dasatinib is a tyrosine kinase inhibitor that can inhibit the Src family of kinases, which TULA (UBASH3A) is known to regulate. By inhibiting Src kinases, Dasatinib can reduce TULA's protein interactions and signaling functions. | ||||||
PP 2 | 172889-27-9 | sc-202769 sc-202769A | 1 mg 5 mg | $94.00 $227.00 | 30 | |
PP2 is an Src family kinase inhibitor. Since TULA has been shown to associate with Src family kinases to modulate their activity, PP2 can inhibit this interaction, thereby functionally inhibiting TULA. | ||||||
SU6656 | 330161-87-0 | sc-203286 sc-203286A | 1 mg 5 mg | $57.00 $133.00 | 27 | |
SU6656 selectively inhibits Src family kinases. By inhibiting these kinases, SU6656 can prevent TULA from exerting its regulatory effects on the Src signaling pathway, thus functionally inhibiting TULA. | ||||||
Saracatinib | 379231-04-6 | sc-364607 sc-364607A | 10 mg 200 mg | $115.00 $1056.00 | 7 | |
Saracatinib is a potent inhibitor of Src family kinases. It can functionally inhibit TULA by blocking the kinases that TULA regulates, thereby inhibiting its interaction with these kinases and downstream signaling. | ||||||
Gö 6976 | 136194-77-9 | sc-221684 | 500 µg | $227.00 | 8 | |
Go6976 is a protein kinase C inhibitor but also has been found to inhibit Src family kinases. It can functionally inhibit TULA by interfering with the kinase activity that TULA is known to modulate. | ||||||
Herbimycin A | 70563-58-5 | sc-3516 sc-3516A | 100 µg 1 mg | $277.00 $1532.00 | 13 | |
Herbimycin A is a tyrosine kinase inhibitor and can inhibit the Hsp90 chaperone complex. Since TULA relies on proper protein folding and function, which involves Hsp90, Herbimycin A can indirectly inhibit TULA's activity. | ||||||
Geldanamycin | 30562-34-6 | sc-200617B sc-200617C sc-200617 sc-200617A | 100 µg 500 µg 1 mg 5 mg | $39.00 $59.00 $104.00 $206.00 | 8 | |
Geldanamycin binds to Hsp90 and inhibits its function. As Hsp90 is essential for the stability and function of several signaling proteins, including those interacting with TULA, this can indirectly inhibit TULA's function. | ||||||
K-252a | 99533-80-9 | sc-200517 sc-200517B sc-200517A | 100 µg 500 µg 1 mg | $129.00 $214.00 $498.00 | 19 | |
K252a is a kinase inhibitor with a broad spectrum, including Trk receptors, which interact with kinases that TULA regulates. By inhibiting these receptors, K252a can indirectly inhibit the functional activity of TULA. | ||||||
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $153.00 $396.00 | 113 | |
Staurosporine is a potent kinase inhibitor affecting a wide range of kinases. It can functionally inhibit TULA by inhibiting upstream kinases that contribute to TULA's regulatory activity in signaling pathways. | ||||||
PD 173955 | 260415-63-2 | sc-507378 | 10 mg | $320.00 | ||
PD173955 is a potent inhibitor of Src family kinases as well as Bcr-Abl. By inhibiting these kinases, PD173955 can indirectly functionally inhibit TULA by preventing its interaction with these kinases. | ||||||