TTC37 Activators
TTC37, or Tetratricopeptide Repeat Domain 37, is a protein encoded by the TTC37 gene in humans. It is part of the TPR protein family, which is characterized by repeated 34-amino acid motifs that form a particular helical structure, facilitating protein-protein interactions. TTC37 is involved in a variety of cellular processes, including intracellular trafficking and protein transport, which are essential for maintaining cellular homeostasis.
The protein is notably implicated in the SKI complex, a multiprotein complex that is involved in the regulation of various aspects of RNA metabolism, including mRNA decay. The SKI complex is critical for the exosome-mediated RNA surveillance pathway, ensuring the degradation of aberrant RNAs and the regulation of normal mRNA levels.Mutations in the TTC37 gene are associated with trichohepatoenteric syndrome (THES), also known as syndromic diarrhea. THES is a rare autosomal recessive disorder characterized by severe diarrhea in infancy, poor growth, distinctive facial features, hair abnormalities, and liver disease.
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Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
May regulate gene expression through retinoic acid receptors, potentially affecting TTC37. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Elevates cAMP, which may modulate transcription factors and influence TTC37 expression. | ||||||
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $91.00 $139.00 $374.00 | 36 | |
Glucocorticoids can regulate gene expression, potentially altering TTC37 levels. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
Activates protein kinase C, which may lead to transcriptional regulation of TTC37. | ||||||
Sodium Salicylate | 54-21-7 | sc-3520 sc-3520A sc-3520B sc-3520C | 1 g 25 g 500 g 1 kg | $10.00 $26.00 $82.00 $139.00 | 8 | |
Inhibits NF-κB signaling, potentially influencing TTC37 transcription. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Modulates transcription factors and signaling pathways, which may alter TTC37 expression. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Influences GSK-3 signaling, potentially affecting TTC37 expression. | ||||||
β-Estradiol | 50-28-2 | sc-204431 sc-204431A | 500 mg 5 g | $63.00 $182.00 | 8 | |
Estrogen receptor signaling can impact gene expression, possibly including TTC37. | ||||||
Rosiglitazone | 122320-73-4 | sc-202795 sc-202795A sc-202795C sc-202795D sc-202795B | 25 mg 100 mg 500 mg 1 g 5 g | $120.00 $326.00 $634.00 $947.00 $1259.00 | 38 | |
PPAR agonists modulate the expression of genes involved in metabolism and inflammation, potentially affecting TTC37. | ||||||
25-Hydroxycholesterol | 2140-46-7 | sc-214091B sc-214091 sc-214091A sc-214091C | 5 mg 10 mg 25 mg 100 mg | $53.00 $91.00 $169.00 $474.00 | 8 | |
Oxysterols regulate lipid metabolism and may influence genes involved in lipid signaling pathways, including TTC37. | ||||||