TTC27 Inhibitors
Chemical inhibitors of TTC27 can exert their inhibitory effects through diverse mechanisms, all of which center around the disruption of microtubule dynamics, a critical aspect of ciliary function and assembly. Microtubules are dynamic structures composed of tubulin polymers that are essential for the proper functioning of cilia, where TTC27 plays a role. Paclitaxel, a chemical known for stabilizing microtubules, inhibits the disassembly of these structures. This stabilization can inadvertently inhibit TTC27 by preventing the necessary dynamic rearrangement of microtubules required for ciliogenesis. Similarly, Eribulin binds to the ends of microtubules, inhibiting their growth, and by this action, it can interfere with the TTC27-dependent processes.
On the other hand, several compounds act by preventing the polymerization of tubulin into microtubules, thereby disrupting the formation and maintenance of cilia where TTC27 is involved. Colchicine, Vincristine, Podophyllotoxin, and Vinblastine are such inhibitors that bind to tubulin, preventing its polymerization and thus affecting ciliary processes. Nocodazole also impedes microtubule polymerization by binding to beta-tubulin, which can affect TTC27 function in ciliogenesis. Likewise, Griseofulvin and Thiabendazole inhibit microtubule polymerization, which in turn can disrupt TTC27's role in the formation and function of cilia. Albendazole and Mebendazole target tubulin and microtubules, leading to the disruption of their assembly, which is imperative for ciliary processes involving TTC27. Through these diverse but related actions, these chemical inhibitors collectively result in the inhibition of TTC27 by targeting the microtubule structures essential for its activity.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Taxol | 33069-62-4 | sc-201439D sc-201439 sc-201439A sc-201439E sc-201439B sc-201439C | 1 mg 5 mg 25 mg 100 mg 250 mg 1 g | $41.00 $74.00 $221.00 $247.00 $738.00 $1220.00 | 39 | |
Paclitaxel stabilizes microtubules and thereby inhibits their disassembly, which is essential for cell cycle progression and cell division. Since TTC27 plays a role in ciliogenesis and cilia are composed of stabilized microtubules, the stabilization effect of Paclitaxel can inhibit the function of TTC27 in cilia formation. | ||||||
Colchicine | 64-86-8 | sc-203005 sc-203005A sc-203005B sc-203005C sc-203005D sc-203005E | 1 g 5 g 50 g 100 g 500 g 1 kg | $100.00 $321.00 $2289.00 $4484.00 $18207.00 $34749.00 | 3 | |
Colchicine binds to tubulin, preventing its polymerization into microtubules, thus disrupting microtubule function. Given that TTC27 is involved in the formation and function of cilia, which rely on microtubule dynamics, colchicine can thereby inhibit the proper functioning of TTC27 in ciliary assembly and maintenance. | ||||||
Nocodazole | 31430-18-9 | sc-3518B sc-3518 sc-3518C sc-3518A | 5 mg 10 mg 25 mg 50 mg | $59.00 $85.00 $143.00 $247.00 | 38 | |
Nocodazole disrupts microtubule polymerization by binding to beta-tubulin. This disruption can affect the trafficking and function of TTC27, which is involved in ciliogenesis and ciliary function, as cilia are dependent on intact microtubules. | ||||||
Podophyllotoxin | 518-28-5 | sc-204853 | 100 mg | $84.00 | 1 | |
Podophyllotoxin inhibits tubulin polymerization, which impacts microtubule assembly. The inhibition of microtubule assembly can disrupt the proper functioning of TTC27, as it is implicated in ciliary processes that depend on microtubule structures. | ||||||
Eribulin | 253128-41-5 | sc-507547 | 5 mg | $865.00 | ||
Eribulin binds microtubule ends and inhibits their growth, which affects cell division. By inhibiting the dynamics of microtubules, Eribulin can interfere with the activity of TTC27, as it is associated with ciliary functions that are dependent on intact microtubules for their assembly and maintenance. | ||||||
Griseofulvin | 126-07-8 | sc-202171A sc-202171 sc-202171B | 5 mg 25 mg 100 mg | $85.00 $220.00 $598.00 | 4 | |
Griseofulvin disrupts microtubule function by binding to polymerized microtubules and interfering with microtubule-associated protein (MAP) functions. This can inhibit the function of TTC27, which requires proper microtubule structures for its role in ciliogenesis. | ||||||
Thiabendazole | 148-79-8 | sc-204913 sc-204913A sc-204913B sc-204913C sc-204913D | 10 g 100 g 250 g 500 g 1 kg | $32.00 $84.00 $183.00 $312.00 $572.00 | 5 | |
Thiabendazole inhibits the polymerization of microtubules, which is critical for the formation and function of cilia. As TTC27 is essential for the proper assembly and functioning of cilia, thiabendazole can inhibit the function of TTC27 by targeting these microtubule-dependent processes. | ||||||
Albendazole | 54965-21-8 | sc-210771 | 100 mg | $213.00 | 1 | |
Albendazole, through its action as an anti-microtubule agent, binds to tubulin monomers and prevents their polymerization, thus inhibiting microtubule formation. As TTC27-related processes in ciliogenesis depend on microtubule dynamics, albendazole can inhibit TTC27 function by disrupting microtubule-dependent ciliary processes. | ||||||
Mebendazole | 31431-39-7 | sc-204798 sc-204798A | 5 g 25 g | $46.00 $89.00 | 2 | |
Mebendazole targets tubulin and microtubules, leading to the disruption of microtubule assembly. By doing so, it can functionally inhibit TTC27, which is necessary for ciliogenesis and ciliary function, as these processes are dependent on the structural integrity of microtubules. | ||||||
Vinblastine | 865-21-4 | sc-491749 sc-491749A sc-491749B sc-491749C sc-491749D | 10 mg 50 mg 100 mg 500 mg 1 g | $102.00 $235.00 $459.00 $1749.00 $2958.00 | 4 | |
Vinblastine binds tubulin, inhibiting microtubule formation, which is essential for cellular processes including ciliogenesis. This inhibition can impede the activity of TTC27, as it affects the proper assembly and function of cilia, which require microtubule integrity, thus functionally inhibiting TTC27. | ||||||