TTC27 Activators
Chemical activators of TTC27 can induce its phosphorylation and activation through various cellular signaling pathways. Forskolin, by elevating cyclic AMP (cAMP) levels, activates protein kinase A (PKA). This cascade can lead to the phosphorylation of TTC27, indicating its role in the cAMP-dependent signaling pathway. Similarly, Ionomycin raises intracellular calcium concentrations, which can activate calmodulin-dependent kinases capable of phosphorylating TTC27, pointing to the involvement of calcium-dependent signaling in its activation. Phorbol 12-myristate 13-acetate (PMA) is another activator that targets protein kinase C (PKC), a kinase that phosphorylates a broad spectrum of proteins, including TTC27, as part of the PKC signaling pathway. Hydrogen peroxide, a reactive oxygen species, can lead to oxidative modifications and the activation of TTC27 through oxidative signaling pathways.
Further, Calyculin A and Okadaic Acid, by inhibiting protein phosphatases 1 and 2A, prevent the dephosphorylation of proteins, thus potentially maintaining TTC27 in an active state. Anisomycin activates stress-activated protein kinases such as JNK, which may phosphorylate TTC27 within stress response signaling pathways. Thapsigargin disrupts calcium homeostasis by inhibiting the sarco/endoplasmic reticulum Ca2+-ATPase (SERCA), leading to increased cytosolic calcium that may activate TTC27 through calcium-mediated signaling. Chloroquine, by disrupting lysosomal function, can alter cellular signaling and activate TTC27. Lithium Chloride, through the inhibition of GSK-3β, can lead to the activation of TTC27 as part of the GSK-3β pathway. Lastly, Zinc Pyrithione, by chelating zinc ions, may induce changes in protein conformations and activate TTC27, as zinc is an essential component of many signaling enzymes and proteins.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $78.00 $270.00 | 80 | |
Ionomycin acts as a calcium ionophore, raising intracellular calcium concentrations. The increase in calcium can activate calmodulin-dependent kinases that could phosphorylate and thereby activate TTC27 in calcium-dependent signaling pathways. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA activates protein kinase C (PKC), which is known to phosphorylate a wide range of target proteins. PKC-mediated phosphorylation can lead to the activation of TTC27 in the PKC signaling pathway. | ||||||
Hydrogen Peroxide | 7722-84-1 | sc-203336 sc-203336A sc-203336B | 100 ml 500 ml 3.8 L | $31.00 $61.00 $95.00 | 28 | |
Hydrogen peroxide, as a reactive oxygen species, can lead to oxidative modifications of proteins, potentially leading to the activation of TTC27 through oxidative signaling pathways. | ||||||
Calyculin A | 101932-71-2 | sc-24000 sc-24000A | 10 µg 100 µg | $163.00 $800.00 | 59 | |
Calyculin A is an inhibitor of protein phosphatases 1 and 2A, preventing the dephosphorylation of proteins. By inhibiting dephosphorylation, Calyculin A could sustain the phosphorylated and activated state of TTC27. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $291.00 $530.00 $1800.00 | 78 | |
Similar to Calyculin A, Okadaic Acid inhibits protein phosphatases, leading to increased phosphorylation levels of proteins. This inhibitor can therefore maintain TTC27 in a phosphorylated, activated state by preventing dephosphorylation. | ||||||
Anisomycin | 22862-76-6 | sc-3524 sc-3524A | 5 mg 50 mg | $99.00 $259.00 | 36 | |
Anisomycin activates stress-activated protein kinases such as JNK, which can lead to the phosphorylation and subsequent activation of TTC27 as part of the stress response signaling pathways. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $136.00 $446.00 | 114 | |
Thapsigargin inhibits the sarco/endoplasmic reticulum Ca2+-ATPase (SERCA), leading to increased cytosolic calcium levels. The rise in calcium can lead to the activation of TTC27 through calcium-mediated signaling pathways. | ||||||
Chloroquine | 54-05-7 | sc-507304 | 250 mg | $69.00 | 2 | |
Chloroquine disrupts lysosomal function, which can lead to alterations in cellular homeostasis and signaling pathways. These alterations could activate TTC27 through pathways associated with cellular stress responses. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium Chloride inhibits GSK-3β, a kinase involved in numerous signaling pathways. Inhibition of GSK-3β can lead to the activation of proteins within these pathways, potentially including TTC27. | ||||||
Zinc | 7440-66-6 | sc-213177 | 100 g | $48.00 | ||
Zinc Pyrithione chelates zinc ions, which can induce conformational changes in proteins and activate signaling pathways that may lead to the functional activation of TTC27, as zinc is a critical cofactor for many proteins and enzymes involved in signaling pathways. | ||||||