TTC26 Inhibitors
TTC26 inhibitors encompass a range of chemical compounds that indirectly impact the functional activity of TTC26 by targeting cellular processes and structures critical to ciliary function and formation, where TTC26 plays a crucial role. Cyclopamine, by inhibiting the Hedgehog signaling pathway, could diminish TTC26 activity as this pathway's signals are integrated through primary cilia. Similarly, agents such as Sirolimus, which inhibits the mTOR pathway, and Lithium Chloride, which impacts the Wnt signaling pathway, could lead to suppressed ciliary function and consequently reduce TTC26 activity due to their regulatory roles in ciliogenesis. Microtubule-disrupting agents like Vincristine, Colchicine, Nocodazole, and Mebendazole, by interfering with microtubule polymerization or stability, pose a significant threat to ciliary integrity, thereby indirectly impeding the function of TTC26, which is intimately associated with the ciliary axoneme. Moreover, Brefeldin A and Pifithrin-α, through their respective disruption of the Golgi apparatus and inhibitionof p53, may compromise ciliogenesis and ciliary maintenance, pathways that are essential for TTC26's role in the cell.
The integrity of cilia and the proper execution of their signaling functions are central to TTC26 activity. Chemicals like Chloroquine and Paclitaxel demonstrate the complexity of ciliary dynamics, with the former elevating lysosomal pH to disrupt autophagy-a process crucial for ciliary maintenance-and the latter stabilizing microtubules to an extent that can negatively impact the dynamic nature required for ciliary function. Retinoic Acid, though primarily known for its role in differentiation, also exerts an influence on ciliary structure and can induce ciliary defects that hinder TTC26 function. Collectively, these TTC26 inhibitors operate by engaging with various cellular pathways and structures that directly or indirectly influence the proper functioning and structural maintenance of cilia. By disrupting these pathways and structures, these chemicals effectively diminish the functional activity of TTC26, underscoring the intricate relationship between ciliary health and TTC26's biological role.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Cyclopamine | 4449-51-8 | sc-200929 sc-200929A | 1 mg 5 mg | $92.00 $204.00 | 19 | |
Cyclopamine is a Hedgehog signaling pathway inhibitor. Since TTC26 is associated with the primary cilium and the Hedgehog signaling is processed through ciliary mechanisms, inhibition of this pathway by Cyclopamine could lead to a reduction in TTC26 function due to decreased Hedgehog pathway activity. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Sirolimus inhibits the mTOR pathway, which is involved in cell growth and proliferation. By inhibiting this pathway, there can be reduced ciliogenesis, which indirectly could decrease the functional activity of TTC26 that is associated with the cilia. | ||||||
Brefeldin A | 20350-15-6 | sc-200861C sc-200861 sc-200861A sc-200861B | 1 mg 5 mg 25 mg 100 mg | $30.00 $52.00 $122.00 $367.00 | 25 | |
Brefeldin A disrupts Golgi apparatus structure and function. Because ciliogenesis requires Golgi-derived vesicles, this compound may indirectly decrease the functional activity of TTC26 by inhibiting cilia formation and maintenance. | ||||||
Chloroquine | 54-05-7 | sc-507304 | 250 mg | $68.00 | 2 | |
Chloroquine raises lysosomal pH and can disrupt autophagy, a process implicated in ciliogenesis and cilia maintenance. As TTC26 is associated with cilia, chloroquine may indirectly inhibit TTC26 function by impairing ciliary maintenance. | ||||||
Colchicine | 64-86-8 | sc-203005 sc-203005A sc-203005B sc-203005C sc-203005D sc-203005E | 1 g 5 g 50 g 100 g 500 g 1 kg | $98.00 $315.00 $2244.00 $4396.00 $17850.00 $34068.00 | 3 | |
Colchicine binds to tubulin, preventing its polymerization and thereby disrupting microtubule function. Since TTC26 is localized in cilia that rely on microtubule stability, colchicine would likely indirectly reduce TTC26 function. | ||||||
Nocodazole | 31430-18-9 | sc-3518B sc-3518 sc-3518C sc-3518A | 5 mg 10 mg 25 mg 50 mg | $58.00 $83.00 $140.00 $242.00 | 38 | |
Nocodazole is a microtubule depolymerizing agent, which would disrupt cilia structure and function. Given the role of TTC26 in cilia, nocodazole could indirectly inhibit TTC26 by affecting ciliary integrity. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic acid regulates differentiation and has been shown to impact ciliogenesis. An excess of retinoic acid can lead to ciliary defects, potentially reducing TTC26 function through indirect impairment of ciliary structure and signaling. | ||||||
Taxol | 33069-62-4 | sc-201439D sc-201439 sc-201439A sc-201439E sc-201439B sc-201439C | 1 mg 5 mg 25 mg 100 mg 250 mg 1 g | $40.00 $73.00 $217.00 $242.00 $724.00 $1196.00 | 39 | |
Paclitaxel stabilizes microtubules and can disrupt normal microtubule dynamics. Since TTC26 function is related to cilia composed of microtubules, paclitaxel could indirectly inhibit TTC26 by affecting ciliary dynamics and structure. | ||||||
Mebendazole | 31431-39-7 | sc-204798 sc-204798A | 5 g 25 g | $45.00 $87.00 | 2 | |
Mebendazole disrupts microtubule synthesis by binding to tubulin. This action can lead to defective ciliogenesis, and thus potentially decrease TTC26 function due to its role in cilia. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium chloride inhibits the Wnt signaling pathway, which is also involved in ciliogenesis and ciliary function. Inhibition of this pathway could indirectly reduce TTC26 activity due to reduced cilia-mediated signaling. | ||||||