TTC21B Inhibitors
TTC21B inhibitors, drawn from the list provided, primarily consist of agents that indirectly modulate the function of TTC21B through their influence on ciliogenesis or related signaling pathways. Cytochalasin D and Nocodazole, for instance, target actin and microtubule dynamics respectively. As these cellular scaffolds are fundamental for cilia formation, their disturbance can indirectly affect the activity of TTC21B, which operates within the ciliary transport system.
Several entries, such as OF-1, Purmorphamine, Vismodegib, RU-SKI 43, ML-210, GANT-61, and SUFU-CH1, are centered around modulating the Hedgehog signaling pathway, a crucial signal transduction system intimately linked to ciliary function. By acting on different components of this pathway, these chemicals have the to disrupt the precise intracellular environment where TTC21B operates, leading to alterations in its activity. Similarly, Ciliobrevin D, a dynein inhibitor, can disrupt cilia function at a fundamental level, offering another avenue through which TTC21B's role might be indirectly modulated.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Cytochalasin D | 22144-77-0 | sc-201442 sc-201442A | 1 mg 5 mg | $165.00 $486.00 | 64 | |
Disrupts actin filaments, which can influence ciliogenesis and potentially the activity of TTC21B. | ||||||
Hydroxy-Dynasore | 1256493-34-1 | sc-364678 | 10 mg | $255.00 | ||
Impedes dynamin, affecting vesicle formation which can indirectly influence ciliogenesis and TTC21B. | ||||||
Ciliobrevin D | 1370554-01-0 | sc-507482 | 10 mg | $413.00 | ||
A dynein inhibitor that can disrupt cilia function and may indirectly influence TTC21B. | ||||||
Purmorphamine | 483367-10-8 | sc-202785 sc-202785A | 1 mg 5 mg | $57.00 $184.00 | 18 | |
Activates SMO in the Hedgehog pathway which is associated with cilia. By modulating this pathway, the function of TTC21B might be affected indirectly. | ||||||
Vismodegib | 879085-55-9 | sc-396759 sc-396759A | 10 mg 25 mg | $82.00 $158.00 | 1 | |
Inhibits SMO in the Hedgehog pathway, which can influence cilia function and potentially the role of TTC21B. | ||||||
Nocodazole | 31430-18-9 | sc-3518B sc-3518 sc-3518C sc-3518A | 5 mg 10 mg 25 mg 50 mg | $59.00 $85.00 $143.00 $247.00 | 38 | |
Depolymerizes microtubules, which can interfere with cilia formation and potentially impact TTC21B's function. | ||||||
Taxol | 33069-62-4 | sc-201439D sc-201439 sc-201439A sc-201439E sc-201439B sc-201439C | 1 mg 5 mg 25 mg 100 mg 250 mg 1 g | $41.00 $74.00 $221.00 $247.00 $738.00 $1220.00 | 39 | |
Stabilizes microtubules, which can alter cilia dynamics and may indirectly influence TTC21B. | ||||||
RU-SKI 43 | 1043797-53-0 | sc-507508 | 5 mg | $395.00 | ||
Hedgehog pathway inhibitor targeting the formation of the ciliary primary cilium, which can influence TTC21B's function. | ||||||
GANT61 | 500579-04-4 | sc-202630 sc-202630A sc-202630B | 1 mg 5 mg 10 mg | $64.00 $131.00 $204.00 | 6 | |
Gli inhibitor, targets Hedgehog signaling associated with cilia, and may indirectly modulate TTC21B. | ||||||