TTC21B Activators
TTC21B activators are a diverse group of chemicals that can enhance the activity of the TTC21B protein. These chemicals can achieve this activation through various mechanisms, including inhibiting kinases that negatively regulate TTC21B activity, elevating the levels of signaling molecules that activate TTC21B, and suppressing signaling pathways that hinder TTC21B activity.
Several chemicals directly inhibit kinases that negatively regulate TTC21B activity, such as lithium chloride, forskolin, and staurosporine. Lithium chloride specifically inhibits the GSK3β kinase, a known negative regulator of TTC21B activity. Forskolin, on the other hand, increases the levels of cyclic AMP (cAMP), a second messenger that can activate various signaling pathways, including the TTC21B activation pathway. Similarly, staurosporine directly inhibits the PKC kinase, another negative regulator of TTC21B activity. Other TTC21B activators indirectly activate TTC21B by inhibiting signaling pathways that suppress TTC21B activity. Wortmannin and rapamycin are prime examples of such chemicals. Wortmannin inhibits the PI3K signaling pathway, which can lead to the activation of the MAPK signaling pathway, which in turn activates TTC21B. Rapamycin, on the other hand, inhibits the mTOR signaling pathway, which can lead to the activation of the AMPK signaling pathway, which in turn activates TTC21B.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
N-Ethylmaleimide | 128-53-0 | sc-202719A sc-202719 sc-202719B sc-202719C sc-202719D | 1 g 5 g 25 g 100 g 250 g | $22.00 $69.00 $214.00 $796.00 $1918.00 | 19 | |
N-Ethylmaleimide (NEM) is an alkylating agent that has been shown to inhibit IFT in a variety of cell types. NEM may also directly activate TTC21B by modifying cysteine residues in the protein. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium chloride (LiCl) is a salt that has been shown to activate TTC21B in a variety of cell types. LiCl can activate TTC21B by inhibiting the GSK3β kinase, which is a negative regulator of TTC21B activity. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin is a diterpene that has been shown to activate TTC21B in a variety of cell types. Forskolin can activate TTC21B by increasing the levels of cyclic AMP (cAMP), which is a second messenger that can activate a variety of signaling pathways, including the TTC21B activation pathway. | ||||||
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $153.00 $396.00 | 113 | |
Staurosporine is a serine/threonine kinase inhibitor that has been shown to activate TTC21B in a variety of cell types. Staurosporine can activate TTC21B by inhibiting the PKC kinase, which is a negative regulator of TTC21B activity. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
Wortmannin is a phosphatidylinositol 3-kinase (PI3K) inhibitor that has been shown to activate TTC21B in a variety of cell types. Wortmannin can activate TTC21B by inhibiting the PI3K signaling pathway, which can lead to the activation of the MAPK signaling pathway, which in turn activates TTC21B. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Rapamycin is a mammalian target of rapamycin (mTOR) inhibitor that has been shown to activate TTC21B in a variety of cell types. Rapamycin can activate TTC21B by inhibiting the mTOR signaling pathway, which can lead to the activation of the AMPK signaling pathway, which in turn activates TTC21B. | ||||||