TrxR2 Inhibitors
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Auranofin | 34031-32-8 | sc-202476 sc-202476A sc-202476B | 25 mg 100 mg 2 g | $153.00 $214.00 $4000.00 | 39 | |
Auranofin is a gold(I)-containing compound that irreversibly inhibits TrxR2 by binding to the selenocysteine residue in the active site, disrupting its redox function. | ||||||
Cisplatin | 15663-27-1 | sc-200896 sc-200896A | 100 mg 500 mg | $138.00 $380.00 | 101 | |
Cisplatin inhibits TrxR2 indirectly through its reactivity with DNA, leading to increased oxidative stress and impaired redox homeostasis. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin, a polyphenol from turmeric, indirectly inhibits TrxR2 by modulating redox-sensitive signaling pathways, altering the enzyme's activity and expression. | ||||||
Gadolinium | 7440-54-2 | sc-250038 | 10 g | $89.00 | ||
This texaphyrin compound selectively targets TrxR2, leading to the disruption of cellular redox balance and enhancement of oxidative stress. | ||||||
Ebselen | 60940-34-3 | sc-200740B sc-200740 sc-200740A | 1 mg 25 mg 100 mg | $33.00 $136.00 $458.00 | 5 | |
Ebselen is a selenium-containing compound that mimics glutathione peroxidase activity and indirectly inhibits TrxR2 by modulating glutathione levels and redox status. | ||||||
PX 12 | 141400-58-0 | sc-358518 sc-358518A | 10 mg 50 mg | $133.00 $505.00 | 9 | |
PX-12, an irreversible inhibitor of TrxR2, covalently modifies the enzyme's active site, leading to the suppression of its activity and disruption of cellular redox balance. | ||||||
8-Hydroxy-5-nitroquinoline | 4008-48-4 | sc-233708 sc-233708A sc-233708B | 5 g 100 g 500 g | $50.00 $90.00 $334.00 | 1 | |
Nitroxoline, an antibiotic, inhibits TrxR2 by chelating metal ions essential for the enzyme's activity, thus impairing its function. | ||||||
Triapine | 200933-27-3 | sc-475303 | 10 mg | $300.00 | ||
Triapine, a thiosemicarbazone derivative, targets TrxR2 by chelating iron, disrupting the enzyme's redox cycle and impairing its function. | ||||||
L-Buthionine sulfoximine | 83730-53-4 | sc-200824 sc-200824A sc-200824B sc-200824C | 500 mg 1 g 5 g 10 g | $286.00 $442.00 $1532.00 $2975.00 | 26 | |
This compound indirectly inhibits TrxR2 by depleting glutathione levels, leading to increased oxidative stress and impaired redox balance. | ||||||