TRPV6 Inhibitors
TRPV6 inhibitors encompass a diverse array of chemicals that intricately modulate the ion channel activity of TRPV6, directly hindering calcium transport. Ruthenium Red, a potent TRPV6 inhibitor, blocks the ion channel pore, preventing calcium influx through the channel. 2-APB interferes with TRPV6 gating mechanisms, disrupting calcium conductivity. SKF 96365 and SKF 96365 hydrochloride specifically interact with TRPV6, preventing calcium ions from passing through the channel. Tamoxifen, primarily known for its antiestrogen activity, exhibits inhibitory effects on TRPV6 by reducing channel activity and interfering with ion channel function. 5'-Iodoresiniferatoxin and Capsazepine specifically block the ion channel pore of TRPV6, inhibiting calcium influx. Naringenin, a natural compound, modulates TRPV6 gating mechanisms, leading to reduced calcium influx. Econazole interferes with TRPV6 ion channel activity, hindering calcium transport.
Cannabidiol (CBD) disrupts TRPV6 ion channel function, leading to reduced calcium influx. Triphenylphosphine oxide and Diphtheria toxin modulate TRPV6 gating mechanisms, directly inhibiting calcium transport. This diverse group of TRPV6 inhibitors provides valuable tools for understanding the role of TRPV6 in cellular calcium homeostasis, paving the way for further investigations into the specific pathways and cellular processes influenced by TRPV6 inhibition. The detailed understanding of these inhibitors and their specific actions on TRPV6 contributes to the development of targeted strategies for modulating cellular calcium dynamics in diverse biological contexts.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Ruthenium red | 11103-72-3 | sc-202328 sc-202328A | 500 mg 1 g | $184.00 $245.00 | 13 | |
Ruthenium Red serves as a direct inhibitor of TRPV6 by blocking the ion channel pore. This compound interacts with the selectivity filter of TRPV6, preventing calcium ions from passing through the channel. The specific blockade of TRPV6 ion conductivity by Ruthenium Red directly inhibits the channel's function, offering a targeted approach to modulating TRPV6 activity. | ||||||
2-APB | 524-95-8 | sc-201487 sc-201487A | 20 mg 100 mg | $27.00 $52.00 | 37 | |
2-APB (2-Aminoethoxydiphenyl borate) is a well-known inhibitor of TRPV6 that acts by disrupting the ion channel activity. It interferes with the channel gating mechanism, leading to the inhibition of calcium influx. By targeting the ion-conducting properties of TRPV6, 2-APB directly hinders the channel's function, offering a pharmacological strategy for inhibiting TRPV6-mediated calcium transport. | ||||||
SK&F 96365 | 130495-35-1 | sc-201475 sc-201475B sc-201475A sc-201475C | 5 mg 10 mg 25 mg 50 mg | $101.00 $155.00 $389.00 $643.00 | 2 | |
SKF 96365 acts as a direct inhibitor of TRPV6 by blocking calcium entry through the ion channel. This compound specifically interacts with TRPV6, preventing the influx of calcium ions. By inhibiting the ion channel activity of TRPV6, SKF 96365 directly modulates the function of TRPV6, providing a targeted approach to inhibit calcium transport mediated by TRPV6. | ||||||
Tamoxifen | 10540-29-1 | sc-208414 | 2.5 g | $256.00 | 18 | |
Tamoxifen, primarily known as an antiestrogen agent, exhibits inhibitory effects on TRPV6 by reducing channel activity. This compound interferes with the ion channel function of TRPV6, leading to decreased calcium influx. The specific modulation of TRPV6 by tamoxifen highlights its potential as a chemical inhibitor, offering a distinct approach to hinder TRPV6-mediated calcium transport. | ||||||
Naringenin | 480-41-1 | sc-219338 | 25 g | $245.00 | 11 | |
Naringenin inhibits TRPV6 activity by interfering with the channel's ion conductivity. This compound modulates the gating mechanism of TRPV6, leading to reduced calcium influx. The specific inhibition of TRPV6 ion channel function by naringenin provides a direct approach to hinder TRPV6-mediated calcium transport, showcasing the potential of this natural compound as a pharmacological inhibitor of TRPV6. | ||||||
Capsazepine | 138977-28-3 | sc-201098 sc-201098A | 5 mg 25 mg | $145.00 $450.00 | 11 | |
Capsazepine serves as a direct inhibitor of TRPV6 by blocking the ion channel pore. This compound specifically interacts with TRPV6, preventing the passage of calcium ions through the channel. The targeted inhibition of TRPV6 ion conductivity by capsazepine directly modulates the function of TRPV6, offering a pharmacological tool for studying calcium transport mediated by TRPV6. | ||||||
Econazole | 27220-47-9 | sc-279013 | 5 g | $240.00 | ||
Econazole inhibits TRPV6 by interfering with the ion channel activity. This compound modulates the gating mechanism of TRPV6, leading to reduced calcium influx. The specific inhibition of TRPV6 ion channel function by econazole provides a direct approach to hinder TRPV6-mediated calcium transport, offering a pharmacological tool for investigating the role of TRPV6 in cellular calcium homeostasis. | ||||||
Diphtheria Toxin, CRM Mutant | 92092-36-9 | sc-203924 | 0.25 mg | $639.00 | 1 | |
Diphtheria toxin, traditionally known for its bacterial toxin activity, exhibits inhibitory effects on TRPV6 by reducing channel activity. This compound interferes with the ion channel function of TRPV6, leading to decreased calcium influx. The specific modulation of TRPV6 by diphtheria toxin highlights its potential as a chemical inhibitor, offering a distinct approach to hinder TRPV6-mediated calcium transport. | ||||||