Date published: 2025-10-25

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TRPM4 Inhibitors

TRPM4, a member of the transient receptor potential (TRP) ion channel family, plays a crucial role in various physiological processes, particularly in the regulation of cellular excitability and ion homeostasis. This non-selective cation channel is predominantly expressed in the heart, brain, and immune cells, where it modulates membrane potential and intracellular calcium levels. Functionally, TRPM4 contributes to the repolarization of cardiac action potentials, thereby influencing cardiac rhythm and contractility. In addition to its role in the heart, TRPM4 also participates in immune responses, where its activation can impact cytokine secretion and immune cell function. Furthermore, TRPM4 channels have been implicated in neurological disorders, highlighting their significance in nervous system function. Inhibition of TRPM4 can be achieved through various mechanisms, each targeting different aspects of channel activity. One common approach involves blocking the ion-conducting pore of TRPM4, thereby preventing the passage of ions through the channel. Additionally, modulation of intracellular signaling pathways involved in TRPM4 regulation can lead to inhibition of channel activity. For instance, inhibition of protein kinases or phosphatases that regulate TRPM4 phosphorylation status can alter channel function. Furthermore, targeting TRPM4 trafficking or expression at the cell membrane can effectively inhibit channel activity.
Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

9-Phenanthrol

484-17-3sc-207225
10 mg
$440.00
2
(1)

9-Phenanthrol inhibits TRPM4 by blocking the channel pore. This direct inhibition prevents the influx of monovalent cations through TRPM4, hindering its role in cellular processes such as calcium signaling and ion homeostasis.

4-Chloro-7-nitrobenzofurazan

10199-89-0sc-214231
sc-214231A
1 g
5 g
$47.00
$137.00
(0)

4-Chloro-7-nitrobenzofurazan inhibits TRPM4 by blocking the channel pore. The direct inhibition of TRPM4 prevents the influx of monovalent cations, impacting cellular processes related to calcium signaling and ion homeostasis.

Flufenamic acid

530-78-9sc-205699
sc-205699A
sc-205699B
sc-205699C
10 g
50 g
100 g
250 g
$26.00
$77.00
$151.00
$303.00
1
(1)

Flufenamic acid inhibits TRPM4 by blocking the channel pore. This direct inhibition prevents the influx of monovalent cations through TRPM4, affecting cellular processes such as calcium signaling and ion homeostasis.

9-AC

723-62-6sc-203483
100 mg
$65.00
(0)

9-AC inhibits TRPM4 by blocking the channel pore. The direct inhibition of TRPM4 prevents the influx of monovalent cations, impacting cellular processes related to calcium signaling and ion homeostasis.

9-Aminoacridine free base

90-45-9sc-291761A
sc-291761
sc-291761B
sc-291761C
250 mg
1 g
5 g
10 g
$31.00
$78.00
$267.00
$491.00
(1)

9-Aminoacridine inhibits TRPM4 by blocking the channel pore. This direct inhibition prevents the influx of monovalent cations through TRPM4, affecting cellular processes such as calcium signaling and ion homeostasis.

2-APB

524-95-8sc-201487
sc-201487A
20 mg
100 mg
$27.00
$52.00
37
(1)

2-Aminoethoxydiphenyl borate inhibits TRPM4 by blocking the channel pore. The direct inhibition of TRPM4 prevents the influx of monovalent cations, affecting cellular processes related to calcium signaling and ion homeostasis.

9-Anthraceneboronic acid

100622-34-2sc-227137
250 mg
$39.00
(0)

9-Anthraceneboronic acid inhibits TRPM4 by blocking the channel pore. This direct inhibition prevents the influx of monovalent cations through TRPM4, affecting cellular processes such as calcium signaling and ion homeostasis.

Piperlongumine

20069-09-4sc-364128
10 mg
$107.00
(1)

Piperlongumine inhibits TRPM4 by blocking the channel pore. The direct inhibition of TRPM4 prevents the influx of monovalent cations, impacting cellular processes related to calcium signaling and ion homeostasis.

Chelerythrine chloride

3895-92-9sc-3547
sc-3547A
5 mg
25 mg
$88.00
$311.00
17
(1)

Chelerythrine chloride inhibits TRPM4 by blocking the channel pore. The direct inhibition of TRPM4 prevents the influx of monovalent cations, impacting cellular processes related to calcium signaling and ion homeostasis.

9-Anthracenemethanol

1468-95-7sc-239135
sc-239135A
5 g
10 g
$45.00
$67.00
(0)

9-Anthracenemethanol inhibits TRPM4 by blocking the channel pore. This direct inhibition prevents the influx of monovalent cations through TRPM4, affecting cellular processes such as calcium signaling and ion homeostasis.