Troponin C slow skeletal Inhibitors
Chemical inhibitors of Troponin C slow skeletal operate by targeting the calcium channels that are essential for the activation of this protein within the muscle contraction pathway. Bepridil, Diltiazem, Verapamil, and Gallopamil are all calcium channel blockers that would lead to a decrease in the intracellular calcium concentration. Since Troponin C slow skeletal requires calcium to bind to initiate conformational changes that are necessary for muscle contraction, the inhibition of these calcium channels by these chemicals results in an indirect inhibition of the protein's function. Similarly, Nifedipine and Amlodipine, by inhibiting the L-type calcium channels, prevent the requisite calcium influx, thus hindering the Troponin C slow skeletal from fulfilling its role in muscle contraction.
Felodipine, Isradipine, Nicardipine, Nimodipine, Nisoldipine, and Lacidipine also contribute to the inhibition of Troponin C slow skeletal through their action as calcium channel blockers. These chemicals reduce the availability of intracellular calcium which is vital for the activation of Troponin C slow skeletal. Without sufficient calcium, the Troponin C slow skeletal cannot undergo the necessary changes to interact with tropomyosin, which is crucial for the muscle fibers to contract. The resulting decrease in available calcium means that the Troponin C slow skeletal remains in an inactive state, unable to participate in muscle contraction, effectively inhibiting its function in the muscle contraction process. Each of these chemicals, by lowering the intracellular calcium levels, ensures that Troponin C slow skeletal is unable to bind calcium and thus remains inhibited, ultimately impacting the contraction mechanism of the muscles.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Bepridil | 64706-54-3 | sc-507400 | 100 mg | $1620.00 | ||
Bepridil inhibits calcium channels, which are crucial for muscle contraction and thus would lead to a decreased calcium influx into muscle cells, indirectly inhibiting Troponin C slow skeletal by preventing its calcium-dependent activation required for muscle contraction. | ||||||
Diltiazem | 42399-41-7 | sc-204726 sc-204726A | 1 g 5 g | $209.00 $464.00 | 4 | |
Diltiazem acts as a calcium channel blocker in cardiac muscle and could inhibit calcium channels in skeletal muscle as well, indirectly inhibiting Troponin C slow skeletal by reducing calcium binding and its regulatory role in muscle contraction. | ||||||
Verapamil | 52-53-9 | sc-507373 | 1 g | $367.00 | ||
Verapamil is another calcium channel blocker that could reduce calcium availability in skeletal muscle, indirectly inhibiting Troponin C slow skeletal action in muscle contraction by limiting calcium-induced conformational changes. | ||||||
Nifedipine | 21829-25-4 | sc-3589 sc-3589A | 1 g 5 g | $58.00 $170.00 | 15 | |
Nifedipine is a dihydropyridine calcium channel blocker that could inhibit L-type calcium channels in skeletal muscle, thus indirectly inhibiting Troponin C slow skeletal by reducing the calcium-triggered troponin-tropomyosin interactions. | ||||||
Amlodipine | 88150-42-9 | sc-200195 sc-200195A | 100 mg 1 g | $73.00 $163.00 | 2 | |
Amlodipine inhibits calcium influx through L-type channels, potentially affecting skeletal muscle contraction and indirectly inhibiting Troponin C slow skeletal by preventing its normal function in muscle contraction regulation. | ||||||
Felodipine | 72509-76-3 | sc-201483 sc-201483A | 10 mg 50 mg | $89.00 $218.00 | 1 | |
Felodipine acts as a calcium channel blocker and could decrease the calcium signal needed for Troponin C slow skeletal to induce the muscle contraction process. | ||||||
Isradipine | 75695-93-1 | sc-201467 sc-201467A | 10 mg 50 mg | $86.00 $318.00 | 1 | |
Isradipine, a calcium channel blocker, could indirectly inhibit Troponin C slow skeletal by lowering the intracellular calcium concentration, which is essential for its activation and function in muscle contraction. | ||||||
Nimodipine | 66085-59-4 | sc-201464 sc-201464A | 100 mg 1 g | $60.00 $301.00 | 2 | |
Nimodipine is a calcium channel blocker that could indirectly inhibit Troponin C slow skeletal by reducing the availability of calcium for binding to the troponin complex during muscle contraction. | ||||||
trans Lacidipine | 103890-78-4 | sc-213066 | 10 mg | $153.00 | ||
Lacidipine, by inhibiting calcium influx, could indirectly inhibit Troponin C slow skeletal by decreasing the calcium levels that are crucial for its function in muscle contraction regulation. | ||||||