Tropomyosin Inhibitors
Tropomyosins, including Tropomyosin β, Tropomyosin γ, and Tropomyosin 4, are a group of proteins crucial for regulating muscle contraction and cytoskeletal dynamics. They form filamentous structures that interact with actin filaments, thereby modulating the access of myosin to actin and regulating muscle contraction. In addition to their role in muscle function, tropomyosins are involved in various cellular processes, including cell migration, intracellular transport, and cell signaling. Tropomyosin isoforms exhibit tissue-specific expression patterns and play distinct roles in different cellular contexts, contributing to the fine-tuning of cellular functions.
Inhibition of tropomyosins can disrupt their interactions with actin filaments, leading to impaired muscle contraction and cytoskeletal dynamics. Various mechanisms can mediate the inhibition of tropomyosin function, including interference with actin-binding sites, disruption of protein-protein interactions, or alteration of tropomyosin conformation. Additionally, molecules targeting tropomyosin-associated regulatory proteins, such as troponin or myosin, can indirectly inhibit tropomyosin function. Pharmacological agents, small molecules, or peptides can be designed to selectively inhibit specific tropomyosin isoforms or disrupt their interactions with actin filaments, providing strategies for conditions associated with abnormal muscle function or cytoskeletal dynamics. Understanding the precise mechanisms of tropomyosin inhibition and its consequences on cellular processes is essential for developing targeted interventions to modulate tropomyosin function in various physiological and pathological contexts.
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Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Colchicine | 64-86-8 | sc-203005 sc-203005A sc-203005B sc-203005C sc-203005D sc-203005E | 1 g 5 g 50 g 100 g 500 g 1 kg | $100.00 $321.00 $2289.00 $4484.00 $18207.00 $34749.00 | 3 | |
Colchicine binds to tubulin, inhibiting its polymerization. This disruption can indirectly affect the actin cytoskeleton and potentially the function of tropomyosins by altering cellular signaling and dynamics, which are crucial for actin-tropomyosin interactions. | ||||||
Cytochalasin D | 22144-77-0 | sc-201442 sc-201442A | 1 mg 5 mg | $165.00 $486.00 | 64 | |
Cytochalasin D binds to the barbed end of actin filaments, preventing their polymerization. This leads to disruption of actin filaments, potentially affecting tropomyosin's role in stabilizing these filaments. | ||||||
Latrunculin A, Latrunculia magnifica | 76343-93-6 | sc-202691 sc-202691B | 100 µg 500 µg | $265.00 $815.00 | 36 | |
Latrunculin A binds to G-actin, inhibiting its incorporation into filaments. This destabilizes actin filaments, potentially impacting tropomyosin's structural role in actin stabilization. | ||||||
Taxol | 33069-62-4 | sc-201439D sc-201439 sc-201439A sc-201439E sc-201439B sc-201439C | 1 mg 5 mg 25 mg 100 mg 250 mg 1 g | $41.00 $74.00 $221.00 $247.00 $738.00 $1220.00 | 39 | |
Taxol stabilizes microtubules, which can indirectly affect actin dynamics and thus tropomyosin function, as actin and microtubule dynamics are interdependent in cells. | ||||||
Nocodazole | 31430-18-9 | sc-3518B sc-3518 sc-3518C sc-3518A | 5 mg 10 mg 25 mg 50 mg | $59.00 $85.00 $143.00 $247.00 | 38 | |
Nocodazole disrupts microtubules by inhibiting their polymerization. This can indirectly influence actin dynamics and potentially affect tropomyosin's interaction with actin filaments. | ||||||
(S)-(−)-Blebbistatin | 856925-71-8 | sc-204253 sc-204253A sc-204253B sc-204253C | 1 mg 5 mg 10 mg 25 mg | $72.00 $265.00 $495.00 $968.00 | ||
Blebbistatin inhibits myosin II, altering muscle contractility and cell motility. This can indirectly affect tropomyosin's role in actin-myosin interactions in muscle and non-muscle cells. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $186.00 $707.00 | 88 | |
Y-27632 is a ROCK inhibitor. By inhibiting ROCK, it can alter actin cytoskeleton dynamics, potentially affecting tropomyosin's role in stabilizing actin filaments. | ||||||
ML-7 hydrochloride | 110448-33-4 | sc-200557 sc-200557A | 10 mg 50 mg | $91.00 $267.00 | 13 | |
ML-7 is an inhibitor of myosin light chain kinase (MLCK). Inhibition of MLCK affects actin-myosin contractility, which could indirectly influence tropomyosin's role in muscle cells. | ||||||
CK 666 | 442633-00-3 | sc-361151 sc-361151A | 10 mg 50 mg | $321.00 $1040.00 | 5 | |
CK-666 is an inhibitor of the Arp2/3 complex, which is involved in actin filament branching. Inhibition of this complex could indirectly affect tropomyosin's interaction with actin filaments. | ||||||
SMIFH2 | 340316-62-3 | sc-507273 | 5 mg | $140.00 | ||
SMIFH2 inhibits formin-mediated actin nucleation. Formin is crucial for actin filament formation, and its inhibition can indirectly impact tropomyosin's role in stabilizing these filaments. | ||||||