tropomodulin 2 Inhibitors
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Colchicine | 64-86-8 | sc-203005 sc-203005A sc-203005B sc-203005C sc-203005D sc-203005E | 1 g 5 g 50 g 100 g 500 g 1 kg | $100.00 $321.00 $2289.00 $4484.00 $18207.00 $34749.00 | 3 | |
Colchicine binds to tubulin, disrupting microtubule dynamics, which tropomodulin 2 stabilizes by capping the pointed ends of actin filaments. Disruption of microtubules can lead to the destabilization of the entire cytoskeletal network, thereby functionally inhibiting the stabilizing action of tropomodulin 2 on actin filaments. | ||||||
Vinblastine | 865-21-4 | sc-491749 sc-491749A sc-491749B sc-491749C sc-491749D | 10 mg 50 mg 100 mg 500 mg 1 g | $102.00 $235.00 $459.00 $1749.00 $2958.00 | 4 | |
Vinblastine interferes with microtubule assembly. Since tropomodulin 2's action is closely related to the cytoskeletal integrity, the disturbance in microtubule dynamics caused by vinblastine can indirectly inhibit the function of tropomodulin 2 by altering the cytoskeletal architecture on which it acts. | ||||||
Cytochalasin D | 22144-77-0 | sc-201442 sc-201442A | 1 mg 5 mg | $165.00 $486.00 | 64 | |
Cytochalasin D binds to the barbed ends of actin filaments, preventing polymerization and elongation. This action can inhibit the role of tropomodulin 2 in maintaining actin filament dynamics by capping the pointed ends, as the overall polymerization state of actin is compromised. | ||||||
Latrunculin A, Latrunculia magnifica | 76343-93-6 | sc-202691 sc-202691B | 100 µg 500 µg | $265.00 $815.00 | 36 | |
Latrunculin A binds to actin monomers and prevents their polymerization, which can inhibit the function of tropomodulin 2 by removing the substrate (actin filaments) it normally caps and stabilizes. | ||||||
Swinholide A, Theonella swinhoei | 95927-67-6 | sc-205914 | 10 µg | $135.00 | ||
Swinholide A severs actin filaments and binds to actin dimers, which can inhibit tropomodulin 2's function by disrupting existing actin filaments and preventing the formation of new ones that tropomodulin 2 would normally stabilize. | ||||||
Pertussis Toxin (islet-activating protein) | 70323-44-3 | sc-200837 | 50 µg | $451.00 | 3 | |
Pertussis Toxin inhibits G-protein coupled receptor signaling, which can lead to changes in intracellular actin dynamics and functionally inhibit tropomodulin 2 by altering the cellular context in which it operates. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $186.00 $707.00 | 88 | |
Y-27632 inhibits the Rho-associated kinase (ROCK), which can lead to decreased phosphorylation of downstream targets that affect actin filament assembly and stability. This may inhibit the function of tropomodulin 2 since it relies on the proper formation and dynamics of actin filaments to exert its stabilizing effect. | ||||||