Trk A Inhibitors
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Gö 6976 | 136194-77-9 | sc-221684 | 500 µg | $227.00 | 8 | |
Gö 6976 is a selective inhibitor of TrkA, demonstrating a unique capacity to modulate neurotrophic signaling pathways. Its interaction with the TrkA receptor involves specific binding that disrupts downstream phosphorylation cascades, effectively altering cellular responses. The compound's structural conformation allows for precise engagement with the receptor's active site, influencing the kinetics of signal transduction. This selectivity highlights its role in regulating neuronal growth and differentiation processes. | ||||||
K-252a | 99533-80-9 | sc-200517 sc-200517B sc-200517A | 100 µg 500 µg 1 mg | $129.00 $214.00 $498.00 | 19 | |
K252a inhibits the kinase activity of Trk A, B, and C which can result in reduced Trk A expression and signaling. | ||||||
Lestaurtinib | 111358-88-4 | sc-218657 sc-218657A sc-218657B | 1 mg 5 mg 10 mg | $275.00 $326.00 $612.00 | 3 | |
Lestaurtinib inhibits Trk A kinase activity, potentially leading to the down-regulation of Trk A expression. | ||||||
TrkA Inhibitor Inhibitor | 388626-12-8 | sc-311553 | 1 mg | $171.00 | 2 | |
TrkA Inhibitor is characterized by its ability to selectively bind to the TrkA receptor, effectively hindering its activation. This compound exhibits unique molecular interactions that prevent the receptor from initiating downstream signaling pathways. By altering the conformational dynamics of the receptor, it influences the kinetics of ligand-receptor interactions, thereby modulating cellular responses. Its distinct binding affinity underscores its role in the intricate network of neurotrophic signaling. | ||||||
GW-441756 | 504433-23-2 | sc-200683 sc-200683A | 10 mg 50 mg | $141.00 $565.00 | 3 | |
GW441756 is a specific Trk A inhibitor that can suppress its kinase activity, potentially leading to reduced expression and function. | ||||||
GW441756 hydrochloride | 504433-24-3 (free base) | sc-215121 | 5 mg | $140.00 | ||
GW441756 hydrochloride functions as a selective antagonist of the TrkA receptor, exhibiting a unique binding profile that stabilizes the receptor in an inactive conformation. This compound disrupts the typical ligand-induced dimerization, thereby impeding the activation of associated signaling cascades. Its specific interactions with key amino acid residues alter the receptor's structural dynamics, influencing the overall kinetics of neurotrophic factor signaling and cellular communication. | ||||||
GNF 5837 | 1033769-28-6 | sc-490003 | 5 mg | $81.00 | 1 | |
GNF-5837 is a potent Trk A inhibitor, which can suppress its activity and might lead to reduced Trk A expression. | ||||||
Entrectinib | 1108743-60-7 | sc-507438 | 5 mg | $180.00 | ||
Entrectinib inhibits Trk A, B, and C, potentially leading to the down-regulation of Trk A expression. | ||||||