Trk A Antibody (Y32Ex): sc-80398

Trk A Antibody (Y32Ex) is a mouse monoclonal IgG2a kappa light chain antibody that detects Trk A protein of human origin by western blotting (WB). Anti-Trk A antibody (Y32Ex) is available as a non-conjugated format. The Trk proto-oncogene encodes a tyrosine protein kinase known as Trk A, which functions as a receptor for essential neurotrophic factors, including nerve growth factor (NGF) and neurotrophin-3 (NT-3). Trk A (Y32Ex) antibody recognizes a protein crucial for neuronal survival, differentiation, and growth, making Trk A essential for the development and maintenance of the nervous system. Trk A is primarily located on the surface of neurons, where Trk A mediates the effects of neurotrophic factors that promote neuronal health and function. NGF binding to Trk A initiates a cascade of intracellular signaling pathways that lead to neuronal survival and the modulation of synaptic plasticity, which is vital for learning and memory. Trk A′s interaction with other proteins, such as phospholipase C-gamma and the Ras-MAPK pathway, underscores Trk A′s importance in neurodevelopment and neuroprotection. Understanding Trk A function and signaling mechanisms can provide insights into various neurological disorders and potential therapeutic targets.

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Trk A Antibody (Y32Ex) References:

1. Alterations in trk A, trk B and trk C receptor immunoreactivities in parietal cortex and cerebellum in Alzheimer's disease.  |  Savaskan, E., et al. 2000. Eur Neurol. 44: 172-80. PMID: 11053967
2. Molecular basis for keratoconus: lack of TrkA expression and its transcriptional repression by Sp3.  |  Lambiase, A., et al. 2005. Proc Natl Acad Sci U S A. 102: 16795-800. PMID: 16275928
3. The trk tyrosine protein kinase mediates the mitogenic properties of nerve growth factor and neurotrophin-3.  |  Cordon-Cardo, C., et al. 1991. Cell. 66: 173-83. PMID: 1649007
4. The trkB tyrosine protein kinase is a receptor for brain-derived neurotrophic factor and neurotrophin-3.  |  Klein, R., et al. 1991. Cell. 66: 395-403. PMID: 1649702
5. Tyrosine phosphorylation and tyrosine kinase activity of the trk proto-oncogene product induced by NGF.  |  Kaplan, DR., et al. 1991. Nature. 350: 158-60. PMID: 1706478
6. Structural and mechanistic insights into nerve growth factor interactions with the TrkA and p75 receptors.  |  Wehrman, T., et al. 2007. Neuron. 53: 25-38. PMID: 17196528
7. The trk family of tyrosine protein kinase receptors.  |  Barbacid, M., et al. 1991. Biochim Biophys Acta. 1072: 115-27. PMID: 1751544
8. TrkA receptor endolysosomal degradation is both ubiquitin and proteasome dependent.  |  Geetha, T. and Wooten, MW. 2008. Traffic. 9: 1146-56. PMID: 18419753
9. Expression patterns of Trk-A, Trk-B, GRP78, and p75NRT in olfactory neuroblastoma.  |  Weinreb, I., et al. 2009. Hum Pathol. 40: 1330-5. PMID: 19386345
10. Expression of the tyrosine kinase receptor gene trkB is confined to the murine embryonic and adult nervous system.  |  Klein, R., et al. 1990. Development. 109: 845-50. PMID: 2171894
11. trkB, a novel tyrosine protein kinase receptor expressed during mouse neural development.  |  Klein, R., et al. 1989. EMBO J. 8: 3701-9. PMID: 2555172
12. The Biased Ligands NGF and NT-3 Differentially Stabilize Trk-A Dimers.  |  Ahmed, F., et al. 2021. Biophys J. 120: 55-63. PMID: 33285113

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Trk A Antibody (Y32Ex) has 2 citations in a variety of scientific publications.

Primary antibodies like Anti-Trk A Antibody (Y32Ex) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Trk A Antibody (Y32Ex) Specifications

Alternate Product Name: TrkA

Product Clone Name: Y32Ex

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids:

Epitope Target: Trk A

Epitope Species: human

Product Reactivity/Detection: Trk A

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB

Vialing Information: Each vial contains 100 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and protein stabilizer

Research Citations: 2 citations in various scientific publications

Available Conjugates/Forms for Trk A Antibody (Y32Ex): N/A

The preferred p-Trk antibody is p-Trk Antibody (E-6): sc-8058.