Molecular structure of GW-441756, CAS Number: 504433-23-2
GW-441756 (CAS 504433-23-2)
See product citations (3)
Alternate Names:
1,3-DIHYDRO-3-[(1-METHYL-1H-INDOL-3-YL)METHYLENE]-2H-PYRROLO[3,2-B]PYRIDIN-2-ONE
Application:
GW-441756 is a specific TrkA tyrosine kinase inhibitor
CAS Number:
504433-23-2
Purity:
>98%
Molecular Weight:
275.3
Molecular Formula:
C17H13N3O
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
GW-441756 is a specific Trk A (tropomyosin-related kinase A) tyrosine kinase inhibitor, reported to block cell death induced by Trk A. Trk A is an important kinase involved in apoptosis, cell differentiation and survival. NGF promotes autophosphorylation of Trk A, which causes Trk A activation.
GW-441756 (CAS 504433-23-2) References
- Apoptotic cell death in TrkA-overexpressing cells: kinetic regulation of ERK phosphorylation and caspase-7 activation. | Jung, EJ. and Kim, DR. 2008. Mol Cells. 26: 12-7. PMID: 18511888
- Cytosolic accumulation of gammaH2AX is associated with tropomyosin-related kinase A-induced cell death in U2OS cells. | Jung, EJ., et al. 2008. Exp Mol Med. 40: 276-85. PMID: 18587265
- Induction of neurite outgrowth in PC12 cells treated with temperature-controlled repeated thermal stimulation. | Kudo, TA., et al. 2015. PLoS One. 10: e0124024. PMID: 25879210
- Trk inhibition reduces cell proliferation and potentiates the effects of chemotherapeutic agents in Ewing sarcoma. | Heinen, TE., et al. 2016. Oncotarget. 7: 34860-80. PMID: 27145455
- Blocking Nerve Growth Factor Signaling Reduces the Neural Invasion Potential of Pancreatic Cancer Cells. | Bapat, AA., et al. 2016. PLoS One. 11: e0165586. PMID: 27792755
- Cholinesterase inhibitor rivastigmine enhances nerve growth factor-induced neurite outgrowth in PC12 cells via sigma-1 and sigma-2 receptors. | Terada, K., et al. 2018. PLoS One. 13: e0209250. PMID: 30557385
- Role of TrkA signaling during tadpole tail regeneration and early embryonic development in Xenopus laevis. | Iimura, A., et al. 2020. Genes Cells. 25: 86-99. PMID: 31788928
- Amitriptyline Reduces Sepsis-Induced Brain Damage Through TrkA Signaling Pathway. | Zhang, L., et al. 2020. J Mol Neurosci. 70: 2049-2057. PMID: 32468218
- Identification of lncRNA-mRNA Regulatory Module to Explore the Pathogenesis and Prognosis of Melanoma. | Zhang, J., et al. 2020. Front Cell Dev Biol. 8: 615671. PMID: 33392203
- BmK NSPK, a Potent Potassium Channel Inhibitor from Scorpion Buthus martensii Karsch, Promotes Neurite Outgrowth via NGF/TrkA Signaling Pathway. | Zhao, F., et al. 2021. Toxins (Basel). 13: PMID: 33466524
- Identification of an m6A-Related Long Noncoding RNA Risk Model for Predicting Prognosis and Directing Treatments in Patients With Colon Adenocarcinoma. | Liao, W., et al. 2022. Front Cell Dev Biol. 10: 910749. PMID: 35912098
Inhibitor of:
Apoptosis, GFRα-4, LPPR2, NGF, Ninein, Trk A, and Trk B.Activator of:
ARHGAP28, Dysadherin, and Trk C.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
GW-441756, 10 mg | sc-200683 | 10 mg | $141.00 | |||
GW-441756, 50 mg | sc-200683A | 50 mg | $565.00 |